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Anand Chandrasekhar

Anand Chandrasekhar

Professor, Biological Sciences

Phone: 573-882-5166
anandc@missouri.edu
340d Bond Life Sciences Center

Anand Chandrasekhar is a professor of biological sciences. Researching with mice and zebrafish, he studies mechanisms involved in the development of the nervous system. He is particularly interested in the development of cranial motor neurons, which are groups of cells controlling the movement of various muscles in the vertebrate head such as the eyes and the jaw. Using cell biology and genetic knockout methods, his lab is currently focused on deciphering the mechanisms regulating the migration of these neurons, and how they organize to establish functional neuronal circuits. These studies will provide insight into the underlying causes of neural tube defects such as spina bifida, and of human neuronal migration disorders, such as lissencephaly, also known as “smooth brain” disorder.

Lab site: Chandrasekhar Lab

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Research Topics

The catalytic activity and secretion of zebrafish RNases are essential for their in vivo function in motor neurons and vasculature. Ferguson R, Holloway DE, Chandrasekhar A, Acharya KR, Subramanian V. Scientific Reports; 9(1):1107.

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Versatile cell ablation tools and their applications to study loss of cell functions. Liu F, Dai S, Feng D, Peng X, Qin Z, Kearns AC, Huang W, Chen Y, Ergün S, Wang H, Rappaport J, Bryda EC, Chandrasekhar A, Aktas B, Hu Hl, Chang SL, Gao B, Qin X. Cellular and Molecular Life Sciences; 76(23):4725-4743.

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Distinct roles for the cell adhesion molecule Contactin2 in the development and function of neural circuits in zebrafish. Gurung S, Asante E, Hummel D, Williams A, Feldman-Schultz O, Halloran MC, Sittaramane V, Chandrasekhar A. Mechanisms of Development; 152:1-12.

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Dissecting branchiomotor neuron circuits in zebrafish – Toward high-throughput automated analysis of jaw movements. Kassim YM, Al-Shakarji N, Asante E, Chandrasekhar A, Palaniappan K. 2018 IEEE 15th International Symposium on Biomedical Imaging; 2018:943-947.

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Zebrafish: from genes and neurons to circuits, behavior and disease. Chandrasekhar A, Guo S, Masai I, Nicolson T, Wu C-F. Journal of Neurogenetics; 31(3):59-60.

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Role of branchiomotor neurons in controlling food intake of zebrafish larvae. Allen JR, Bhattacharyya KD, Asante E, Almadi B, Schafer K, Davis J, Cox J, Voigt M, Viator JA, Chandrasekhar A. Journal of Neurogenetics; 31(3):128-137.

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The atypical cadherin Celsr1 functions non-cell autonomously to block rostral migration of facial branchiomotor neurons in mice. Glasco DM, Pike W, Qu Y, Reustle L, Misra K, Di Bonito M, Studer M, Fritzsch B, Goffinet AM, Tissir F, Chandrasekhar A. Developmental Biology; 417(1):40-49.

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Quantitative photoacoustics to measure single cell melanin production and nanoparticle attachment. Bhattacharyya K, Eshein A, Chandrasekhar A, Viator JA. Physics in Medicine and Biology; 60(8):3081-3096.

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A dynamic intracellular distribution of Vangl2 accompanies cell polarization during zebrafish gastrulation. Roszko I, Sepich DS, Jessen JR, Chandrasekhar A, Solnica-Krezel L. Development (Cambridge); 142(14):2508-2520.

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Analysis of prickle1 in human cleft palate and mouse development demonstrates rare and common variants involved in human malformations. Yang T, Jia Z, Bryant-Pike W, Chandrasekhar A, Murray JC, Fritzsch B, Bassuk AG. Molecular Genetics and Genomic Medicine; 2(2):138-151.

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Structural and temporal requirements of Wnt/PCP protein Vangl2 function for convergence and extension movements and facial branchiomotor neuron migration in zebrafish. Pan X, Sittaramane V, Gurung S, Chandrasekhar A. Mechanisms of Development; 131(1):1-14.

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The PCP protein Vangl2 regulates migration of hindbrain motor neurons by acting in floor plate cells, and independently of cilia function. Sittaramane V, Pan X, Glasco DM, Huang P, Gurung S, Bock A, Li S, Wang H, Kawakami K, Matise MP, Chandrasekhar A. Developmental Biology; 382(2):400-412.

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The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled. Glasco DM, Sittaramane V, Bryant W, Fritzsch B, Sawant A, Paudyal A, Stewart M, Andre P, Cadete Vilhais-Neto G, Yang Y, Song M-R, Murdoch JN, Chandrasekhar A. Developmental Biology; 369(2):211-222.

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Brainstem respiratory oscillators develop independently of neuronal migration defects in the WNT/PCP mouse mutant looptail. Thoby-Brisson M, Bouvier J, Glasco DM, Stewart ME, Dean C, Murdoch JN, Champagnat J, Fortin G, Chandrasekhar A. PLoS ONE; 7(2):e31140.

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Evolutionarily conserved function of Gbx2 in anterior hindbrain development. Burroughs-Garcia J, Sittaramane V, Chandrasekhar A, Waters ST. Developmental Dynamics; 240(4):828-838.

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Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. Qu Y, Glasco DM, Zhou L, Sawant A, Ravni A, Fritzsch B, Damrau C, Murdoch JN, Evans S, Pfaff SL, Formstone C, Goffinet AM, Chandrasekhar A, Tissir F. Journal of Neuroscience; 30(28):9392-9401.

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Knockdown of bicaudal C in zebrafish (Danio rerio) causes cystic kidneys: A nonmammalian model of polycystic kidney disease. Bouvrette DJ, Sittaramane V, Heidel JR, Chandrasekhar A, Bryda EC. Comparative Medicine; 60(2):96-106.

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Multiple mechanisms mediate motor neuron migration in the zebrafish hindbrain. Bingham SM, Sittaramane V, Mapp O, Patil S, Prince VE, Chandrasekhar A. Developmental Neurobiology; 70(2):87-99.

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The cell adhesion molecule Tag1, transmembrane protein Stbm/Vangl2, and Lamininα1 exhibit genetic interactions during migration of facial branchiomotor neurons in zebrafish. Sittaramane V, Sawant A, Wolman MA, Maves L, Halloran MC, Chandrasekhar A. Developmental Biology; 325(2):363-373.

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Transient axonal glycoprotein-1 (TAG-1) and laminin-α1 regulate dynamic growth cone behaviors and initial axon direction in vivo. Wolman MA, Sittaramane VK, Essner JJ, Yost HJ, Chandrasekhar A, Halloran MC. Neural Development; 3(1):6.

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Expression of unconventional myosin genes during neuronal development in zebrafish. Sittaramane V, Chandrasekhar A. Gene Expression Patterns; 8(3):161-170.

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Neuronal development and migration in zebrafish hindbrain explants. Bingham SM, Toussaint G, Chandrasekhar A. Journal of Neuroscience Methods; 149(1):42-49.

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Gli function is essential for motor neuron induction in zebrafish. Vanderlaan G, Tyurina OV, Karlstrom RO, Chandrasekhar A. Developmental Biology; 282(2):550-570.

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Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos. Teraoka H, Russell C, Regan J, Chandrasekhar A, Concha ML, Yokoyama R, Higashi K, Take-Uchi M, Dong W, Hiraga T, Holder N, Wilson SW. Journal of Neurobiology; 60(3):275-288.

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Turning Heads: Development of Vertebrate Branchiomotor Neurons. Chandrasekhar, A. Developmental Dynamics; 229(1):143-161.

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Neurogenic Phenotype of mind bomb Mutants Leads to Severe Patterning Defects in the Zebrafish Hindbrain. Bingham S, Chaudhari S, Vanderlaan G, Itoh M, Chitnis A, Chandrasekhar A. Developmental Dynamics; 228(3):451-463.

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The zebrafish trilobite gene is essential for tangential migration of branchiomotor neurons. Bingham S, Higashijima S-I, Okamoto H, Chandrasekhar A. Developmental Biology; 242(2):149-160.

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Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements. Jessen JR, Topczewski J, Bingham S, Sepich DS, Marlow F, Chandrasekhar A, Solnica-Krezel L. Nature Cell Biology; 4(8):610-615.

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Sonic hedgehog and tiggy-winkle hedgehog cooperatively induce zebrafish branchiomotor neurons. Bingham S, Nasevicius A, Ekker SC, Chandrasekhar A. Genesis; 30(3):170-174.

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The zebrafish detour gene is essential for cranial but not spinal motor neuron induction. Chandrasekhar A, Schauerte HE, Haffter P, Kuwada JY. Development; 126(12):2727-2737.

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Molecular cloning, expression, and activity of zebrafish semaphorin Z1a. Yee CS, Chandrasekhar A, Halloran MC, Shoji W, Warren JT, Kuwada JY. Brain Research Bulletin; 48(6):581-593.

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Molecular cloning and developmental expression of a zebrafish axonal glycoprotein similar to TAG-1. Warren JT Jr, Chandrasekhar A, Kanki JP, Rangarajan R, Furley AJ, Kuwada JY. Mechanisms of Development; 80(2):197-201.

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Role of sonic hedgehog in branchiomotor neuron induction in zebrafish. Chandrasekhar A, Warren JT Jr, Takahashi K, Schauerte HE, Van Eeden FJM, Haffter P, Kuwada JY. Mechanisms of Development; 76(1-2):101-115.

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Development of branchiomotor neurons in zebrafish. Chandrasekhar A, Moens CB, Warren JT Jr, Kimmel CB, Kuwada JY. Development; 124(13):2633-2644.

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Ponticulin plays a role in the positional stabilization of pseudopods. Shutt DC, Wessels D, Wagenknecht K, Chandrasekhar A, Hitt AL, Luna EJ, Soll DR. Journal of Cell Biology; 131(6):1495-1506.

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A mutation that depresses cGMP phosphodiesterase activity in Dictyostelium affects cell motility through an altered chemotactic signal. Chandrasekhar A, Wessels D, Soll DR. Developmental Biology; 169(1):109-122.

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Functional analysis of the promoter of the phase-specific WH11 gene of Candida albicans. Srikantha T, Chandrasekhar A, Soll DR. Molecular and Cellular Biology; 15(3):1797-1805.

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Biological and molecular correlates between induced dedifferentiation and spore germination in Dictyostelium. Chandrasekhar A, Ennis HL, Soll DR. Development; 116(2):417-425.

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Developmental mechanisms regulating the rapid decrease in a cohesion glycoprotein mRNA in Dictyostelium function primarily at the level of mRNA degradation. Chandrasekhar A, Rotman M, Kraft B, Soll DR. Developmental Biology; 141(2):262-269.

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Dictyostelium erasure mutant HI4 abnormally retains development-specific mRNAs during dedifferentiation. Kraft B, Chandrasekhar A, Rotman M, Klein C, Soll DR. Developmental Biology; 136(2):363-371.

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