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Cheryl S. Rosenfeld

Cheryl S. Rosenfeld

Professor of Biomedical Sciences

Phone: 573-882-5132
RosenfeldC@missouri.edu
440f Life Sciences Center

Rosenfeld specializes in studying the effects of maternal diet on offspring, exploring how the in-utero environment can shape risks for later disease. Her research with mice has yielded majorbreakthroughs. She has determined that an energy-rich maternal diet will result in more male mouse pups, while a restricted-calorie diet produces daughtersmore frequently. She also established a relationship between a certain hair-coat color and obesity and diabetes in mice. Most recently, the Rosenfeld lab has identified spatial learning disabilities in male deer mice whose mothers consumed a diet supplemented with bisphenol A, (BPA), a known endocrine disruptor and a common pollutant. This disability is expected to hinder themales in navigating to find mates; the finding has implications for deer mice populations exposed to BPA in the wild.

News about Cheryl S. Rosenfeld

Effect of maternal obesity on estrous cyclicity, embryo development and blastocyst gene expression in a mouse model. Bermejo-Alvarez P, Rosenfeld CS, Roberts RM. Human Reproduction; 27(12):3513-3522.

Featured in this article: Cheryl Rosenfeld, Michael Roberts.

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Sexually selected traits: a fundamental framework for studies on behavioral epigenetics. Jašarević E, Geary DC, Rosenfeld CS. ILAR journal / National Research Council, Institute of Laboratory Animal Resources; 53(3-4):253-269.

Featured in this article: Cheryl Rosenfeld.

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Comparison of serum bisphenol a concentrations in mice exposed to bisphenol a through the diet versus oral bolus exposure. Sieli PT, Jašarević E, Warzak DA, Mao J, Ellersieck MR, Liao C, Kannan K, Collet SH, Toutain P-L, Saal FSVS, Rosenfeld CS. Environmental Health Perspectives; 119(9):1260-1265.

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Disruption of adult expression of sexually selected traits by developmental exposure to bisphenol A. Jašarevića E, Sieli PT, Twellman EE, Welsh TH Jr, Schachtman TR, Roberts RM, Geary DC, Rosenfeld CS. Proceedings of the National Academy of Sciences of the United States of America; 108(28):11715-11720.

Featured in this article: Michael Roberts, Cheryl Rosenfeld.

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Contrasting effects of different maternal diets on sexually dimorphic gene expression in the murine placenta. Mao J, Zhang X, Sieli PT, Falduto MT, Torres KE, Rosenfeld CS. Proceedings of the National Academy of Sciences of the United States of America; 107(12):5557-5562.

Featured in this article: Jiude Mao, Cheryl Rosenfeld.

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Animal models to study environmental epigenetics. Rosenfeld CS. Biology of Reproduction; 82(3):473-488.

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Flawed experimental design reveals the need for guidelines requiring appropriate positive controls in endocrine disruption research. vom Saal FS, Akingbemi BT, Belcher SM, Crain DA, Crews D, Guidice LC, Hunt PA, Leranth C, Myers JP, Nadal A, Olea N, Padmanabhan V, Rosenfeld CS, Schneyer A, Schoenfelder G, Sonnenschein C, Soto AM, Stahlhut RW, Swan SH, Vandenberg LN, Wang H-S, Watson CS, Welshons WV, Zoeller RT. Toxicological Sciences; 115(2):612-613.

Featured in this article: Cheryl Rosenfeld.

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Usage of X- and Y-chromosome fluorescent in situ hybridization to determine whether the murine oocytes selectively attract one class of spermatozoa over another. Mao J, Rosenfeld CS. Molecular Reproduction and Development; 76(4):320.

Featured in this article: Jiude Mao, Cheryl Rosenfeld.

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Comparative effects of estradiol, methyl-piperidino-pyrazole, raloxifene, and ICI 182 780 on gene expression in the murine uterus. Davis AM, Mao J, Naz B, Kohl JA, Rosenfeld CS. Journal of Molecular Endocrinology; 41(3-4):205-217.

Featured in this article: Jiude Mao, Cheryl Rosenfeld.

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Histology, Cellular and Molecular Biology of Reproductive Organs: Part 3.2 Overview of Male Reproductive Organs. Rosenfeld CS, Schatten H. Comparative Reproductive Biology; 69-79.

Featured in this article: Cheryl Rosenfeld.

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Histology, Cellular and Molecular Biology of Reproductive Organs: Part 3.4 Overview of Female Reproductive Organs. Rosenfeld CS, Schatten H. Comparative Reproductive Biology; 99-109.

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Introduction to Comparative Placentation. Rosenfeld CS. Comparative Reproductive Biology; 263-270.

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Effects of diets enriched in omega-3 and omega-6 polyunsaturated fatty acids on offspring sex-ratio and maternal behavior in mice. Fountain ED, Mao J, Whyte JJ, Mueller KE, Ellersieck MR, Will MJ, Roberts RM, MacDonald R, Rosenfeld CS. Biology of Reproduction; 78(2):211-217.

Featured in this article: Jiude Mao, Michael Roberts, Cheryl Rosenfeld.

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The contrasting effects of Ad libitum and restricted feeding of a diet very high in saturated fats on sex ratio and metabolic hormones in mice. Alexenko AP, Mao J, Ellersieck MR, Davis AM, Whyte JJ, Rosenfeld CS, Roberts RM. Biology of Reproduction; 77(4):599-604.

Featured in this article: Jiude Mao, Cheryl Rosenfeld, Michael Roberts.

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Fluorescent in situ hybridization for sex chromosome determination before and after fertilization in mice. Whyte JJ, Roberts RM, Rosenfeld CS. Theriogenology; 67(5):1022-1031.

Featured in this article: Michael Roberts, Cheryl Rosenfeld.

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Maternal diet composition alters serum steroid and free fatty acid concentrations and vaginal pH in mice. Whyte JJ, Alexenko AP, Davis AM, Ellersieck MR, Fountain ED, Rosenfeld CS. Journal of Endocrinology; 192(1):75-81.

Featured in this article: Cheryl Rosenfeld.

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The effects of the selective estrogen receptor modulators, methyl-piperidino-pyrazole (MPP), and raloxifene in normal and cancerous endometrial cell lines and in the murine uterus. Davis AM, Ellersieck MR, Grimm KM, Rosenfeld CS. Molecular Reproduction and Development; 73(8):1034-1044.

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Effect of interferon-τ administration on endometrium of nonpregnant ewes: A comparison with pregnant ewes. Chen Y, Green JA, Antoniou E, Ealy AD, Mathialagan N, Walker AM, Avalle MP, Rosenfeld CS, Hearne LB, Roberts RM. Endocrinology; 147(5):2127-2137.

Featured in this article: Cheryl Rosenfeld, Michael Roberts.

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Maternal diet and other factors affecting offspring sex ratio: A review. Rosenfeld CS, Roberts RM. Biology of Reproduction; 71(4):1063-1070.

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Striking variation in the sex ratio of pups born to mice according to whether maternal diet is high in fat or carbohydrate. Rosenfeld CS, Grimm KM, Livingston KA, Brokman AM, Lamberson WE, Roberts RM. Proceedings of the National Academy of Sciences of the United States of America; 100(8):4628-4632.

Featured in this article: Cheryl Rosenfeld, Michael Roberts.

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Estrogen receptor-α gene deficiency enhances androgen biosynthesis in the mouse Leydig cell. Akingbemi BT, Ge R, Rosenfeld CS, Newton LG, Hardy DO, Catterall JF, Lubahn DB, Korach KS, Hardy MP. Endocrinology; 144(1):84-93.

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Evolution of the interferon tau genes and their promoters, and maternal-trophoblast interactions in control of their expression. Roberts RM, Ezashi T, Rosenfeld CS, Ealy AD, Kubisch HM. Reproduction (Cambridge, England) Supplement; 61:239-251.

Featured in this article: Michael Roberts, Toshihiko Ezashi, Cheryl Rosenfeld.

Expression of interferon receptor subunits, IFNAR1 and IFNAR2, in the ovine uterus. Rosenfeld CS, Han C-S, Alexenko AP, Spencer TE, Roberts RM. Biology of Reproduction; 67(3):847-853.

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An aspartic proteinase expressed in the yolk sac and neonatal stomach of the mouse. Chen X, Rosenfeld CS, Roberts RM, Green JA. Biology of Reproduction; 65(4):1092-1101.

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Expression of the bovine oestrogen receptor-β (bERβ) messenger ribonucleic acid (mRNA) during the first ovarian follicular wave and lack of change in the expression of bERβ mRNA of second wave follicles after LH infusion into cows. Manikkam M, Bao B, Rosenfeld CS, Yuan X, Salfen BE, Calder MD, Youngquist RS, Keisler DH, Lubahn DB, Garverick HA. Animal Reproduction Science; 67(3-4):159-169.

Featured in this article: Cheryl Rosenfeld.

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Intraovarian actions of oestrogen. Rosenfeld CS, Wagner JS, Roberts RM, Lubahn DB. Reproduction; 122(2):215-226.

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Estrogen receptor- and aromatase-deficient mice provide insight into the roles of estrogen within the ovary and uterus. Rosenfeld CS, Michael Roberts R, Lubahn DB. Molecular Reproduction and Development; 59(3):336-346.

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The differential fate of mesonephric tubular-derived efferent ductules in estrogen receptor-α knockout versus wild-type female mice. Rosenfeld CS, Cooke PS, Welsh TH Jr, Simmer G, Hufford MG, Gustafsson J-A, Hess RA, Lubahn DB. Endocrinology; 141(10):3792-3798.

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Normal development of thymus in male and female mice requires estrogen/estrogen receptor-α signaling pathway. Yellayi S, Teuscher C, Woods JA, Welsh TH Jr, Tung KSK, Nakai M, Rosenfeld CS, Lubahn DB, Cooke PS. Endocrine; 12(3):207-213.

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Centrosome-centriole abnormalities are markers for abnormal cell divisions and cancer in the transgenic adenocarcinoma mouse prostate (TRAMP) model. Schatten H, Wiedemeier AMD, Taylor M, Lubahn DB, Greenberg NM, Besch-Williford C, Rosenfeld CS, Kevin Day J, Ripple M. Biology of the Cell; 92(5):331-340.

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Gonadotropin induction of ovulation and corpus luteum formation in young estrogen receptor-α knockout mice. Rosenfeld CS, Murray AA, Simmer G, Hufford MG, Smith MF, Spears N, Lubahn DB. Biology of Reproduction; 62(3):599-605.

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Cloning, sequencing, and localization of bovine estrogen receptor-β within the ovarian follicle. Rosenfeld CS, Yuan X, Manikkam M, Calder MD, Garverick HA, Lubahn DB. Biology of Reproduction; 60(3):691-697.

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Transcription and translation of estrogen receptor-β in the male reproductive tract of estrogen receptor-α knock-out and wild-type mice. Rosenfeld CS, Ganjam VK, Taylor JA, Yuan X, Stiehr JR, Hardy MP, Lubahn DB. Endocrinology; 139(6):2982-2987.

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Intracranial squamous cell carcinoma causing Homer’s syndrome in a cow. Pace LW, Wallace L, Rosenfeld CS, Sansone J. Journal of Veterinary Diagnostic Investigation; 9(1):106-108.

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