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David J. Pintel

David J. Pintel

Dr. R. Phillip and Diane Acuff Endowed Professor in Medical Research Molecular Microbiology and Immunology (MMI)

Phone: 573-882-3920
PintelD@missouri.edu
471f Life Sciences Center

The Pintel lab focuses upon developing better understanding of the interaction between viruses and host cells. Pintel specializes in the study of parvoviruses, the smallest of all DNA viruses that infect vertebrates. Parvoviruses are important pathogens of many animal species including humans. In addition, the parvovirus adeno-associated virus (AAV) has been developed as a promising gene therapy vehicle. In past years, Pintel conducted research on how parvoviruses replicate. Currently he is studying virus-host interactions: how infected cells fight off attacks by this pathogen, and how the virus, in turn, tries to overcome the cell’s defenses. Insights into the details of this complex battle could reveal new methods of intervention that may inhibit the replication of parvoviruses and other DNA viruses.

News about David J. Pintel

Minute virus of mice small non-structural protein NS2 localizes within, but is not required for the formation of, Smn-associated autonomous parvovirus-associated replication bodies. Young PJ, Newman A, Jensen KT, Burger LR, Pintel DJ, Lorson CL. Journal of General Virology; 86(4):1009-1014.

Featured in this article: Lisa Burger, David Pintel, Christian Lorson.

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Minute virus of mice small nonstructural protein NS2 interacts and colocalizes with the Smn protein. Young PJ, Jensen KT, Burger LR, Pintel DJ, Lorson CL. Journal of Virology; 76(12):6364-6369.

Featured in this article: Lisa Burger, David Pintel, Christian Lorson.

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Minute virus of mice NS1 interacts with the SMN protein, and they colocalize in novel nuclear bodies induced by parvovirus infection. Young PJ, Jensen KT, Burger LR, Pintel DJ, Lorson CL. Journal of Virology; 76(8):3892-3904.

Featured in this article: Lisa Burger, David Pintel, Christian Lorson.

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An SP1-binding site and TATA element are sufficient to support full transactivation by proximally bound NS1 protein of minute virus of mice. Lorson C, Pearson J, Burger L, Pintel DJ. Virology; 240(2):326-337.

Featured in this article: Christian Lorson, Lisa Burger, David Pintel.

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Characterization of the minute virus of mice P38 core promoter elements. Lorson C, Pintel DJ. Journal of Virology; 71(9):6568-6575.

Featured in this article: Christian Lorson, David Pintel.

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Efficient transactivation of the minute virus of mice P38 promoter requires upstream binding of NS1. Lorson C, Burger LR, Mouw M, Pintel DJ. Journal of Virology; 70(2):834-842.

Featured in this article: Christian Lorson, Lisa Burger, David Pintel.

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