471f Life Sciences Center
The Pintel lab focuses upon developing better understanding of the interaction between viruses and host cells. Pintel specializes in the study of parvoviruses, the smallest of all DNA viruses that infect vertebrates. Parvoviruses are important pathogens of many animal species including humans. In addition, the parvovirus adeno-associated virus (AAV) has been developed as a promising gene therapy vehicle. In past years, Pintel conducted research on how parvoviruses replicate. Currently he is studying virus-host interactions: how infected cells fight off attacks by this pathogen, and how the virus, in turn, tries to overcome the cell’s defenses. Insights into the details of this complex battle could reveal new methods of intervention that may inhibit the replication of parvoviruses and other DNA viruses.