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Mark Hannink

Mark Hannink

Professor, Biochemistry

Phone: 573-882-7971
hanninkm@missouri.edu
440e Bond Life Sciences Center

Mark Hannick is a professor of biochemistry. The Hannink laboratory studies the molecular mechanisms that regulate how cells respond to their environment. In particular, his lab is interested in understanding how human cells sense and respond to oxidative stress. Oxidative stress has been implicated in many disease processes, including cancer, heart failure, kidney disease, liver disease and neurodegenerative diseases such as Parkinson’s and Alzheimer’s. Oxidative stress results from an imbalance between highly reactive oxygen molecules produced by normal cellular processes and the anti-oxidant molecules that help cells neutralize and eliminate reactive and toxic molecules. The Hannink lab has identified several protein complexes that regulate cellular responses to oxidative stress and is interested in developing therapeutic approaches that target these protein complexes and will increase the ability of normal cells to withstand oxidative stress.

News about Mark Hannink

Research Topics

2020

Heme oxygenase promotes B-Raf-dependent melanosphere formation. Jasmer KJ, Hou J, Mannino P, Cheng J, Hannink M. Pigment Cell and Melanoma Research; 33(6):850-868.

Date published: November 1, 2020
Featured in this article: Kimberly Jasmer, Mark Hannink.

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2019

Nrf2-inducing and HMG-CoA reductase inhibitory activities of a polyphenol-rich fraction of Guazuma ulmifolia leaves. Sulistiyani S, Falah S, Wahyuni W, Andrianto D, Lelono A, Nurcholis W, Mossine V, Hannink M. Asian Pacific Journal of Tropical Biomedicine; 9(9):389-396.

Date published: September 1, 2019
Featured in this article: Mark Hannink.

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Effects of moloney leukemia virus 10 protein on hepatitis B virus infection and viral replication. Puray-Chavez MN, Farghali MH, Yapo V, Huber AD, Liu D, Ndongwe TP, Casey MC, Laughlin T, Hannink M, Tedbury PR, Sarafianos SG. Viruses; 11(7):651.

Date published: July 1, 2019
Featured in this article: Mark Hannink.

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Exploring the molecular genetic foundations of cancer biology and how biomedical advances are made in an advanced undergraduate course. Alexander S, Hannink M. Biochemistry and Molecular Biology Education; 47(4):408-416.

Date published: July 1, 2019
Featured in this article: Mark Hannink.

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HDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 target gene expression. Hu T, Schreiter FC, Bagchi RA, Tatman PD, Hannink M, McKinsey TA. Journal of Biological Chemistry; 294(21):8640-8652.

Date published: May 24, 2019
Featured in this article: Mark Hannink.

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2018

Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases. Sun GY, Simonyi A, Fritsche KL, Chuang DY, Hannink M, Gu Z, Greenlief CM, Yao JK, Lee JC, Beversdorf DQ. Prostaglandins Leukotrienes and Essential Fatty Acids; 136:3-13.

Date published: September 1, 2018
Featured in this article: Mark Hannink, Michael Greenlief.

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Assembly of PGAM5 into Multimeric Complexes Provides a Mechanism for Allosteric Regulation of Phosphatase Activity. Tipton P, Su T, Hannink M. Methods in Enzymology; 607:353-372.

Date published: January 1, 2018
Featured in this article: Mark Hannink.

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Cancer as a mutation-driven evolutionary process. Hannink M, Temin HM. Growth Regulation and Carcinogenesis: Volume I; 95-97.

Date published: January 1, 2018
Featured in this article: Mark Hannink.

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Mutation-driven evolution of rev-T. Hannink M, Temin HM. Growth Regulation and Carcinogenesis: Volume I; 99-109.

Date published: January 1, 2018
Featured in this article: Mark Hannink.

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2016

Withania somnifera and Its Withanolides Attenuate Oxidative and Inflammatory Responses and Up-Regulate Antioxidant Responses in BV-2 Microglial Cells. Sun GY, Li R, Cui J, Hannink M, Gu Z, Fritsche KL, Lubahn DB, Simonyi A. NeuroMolecular Medicine; 18(3):241-252.

Date published: September 1, 2016
Featured in this article: Mark Hannink.

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Phytochemicals and botanical extracts regulate NF-κB and Nrf2/ARE reporter activities in di TNC1 astrocytes. Ajit D, Simonyi A, Li R, Chen Z, Hannink M, Fritsche KL, Mossine VV, Smith RE, Dobbs TK, Luo R, Folk WR, Gu Z, Lubahn DB, Weisman GA, Sun GY. Neurochemistry International; 97:49-56.

Date published: July 1, 2016
Featured in this article: Mark Hannink, Gary Weisman.

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2015

Quercetin attenuates inflammatory responses in BV-2 microglial cells: Role of MAPKs on the Nrf2 pathway and induction of heme oxygenase-1. Sun GY, Chen Z, Jasmer KJ, Chuang DY, Gu Z, Hannink M, Simonyi A. PLoS ONE; 10(10):e0141509.

Date published: October 27, 2015
Featured in this article: Kimberly Jasmer, Mark Hannink.

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From gigabyte to kilobyte: A bioinformatics protocol for mining large RNA-Seq transcriptomics data. Li J, Hou J, Sun L, Wilkins JM, Lu Y, Niederhuth CE, Merideth BR, Mawhinney TP, Mossine VV, Greenlief CM, Walker JC, Folk WR, Hannink M, Lubahn DB, Birchler JA, Cheng J. PLoS ONE; 10(4):e0125000.

Date published: April 22, 2015
Featured in this article: Michael Greenlief, Mark Hannink.

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2014

Proteomic analysis of the effects of aged garlic extract and its FruArg component on lipopolysaccharide-induced neuroinflammatory response in microglial cells. Zhou H, Qu Z, Mossine VV, Nknolise DL, Li J, Chen Z, Cheng J, Greenlief CM, Mawhinney TP, Brown PN, Fritsche KL, Hannink M, Lubahn DB, Sun GY, Gu Z. PLoS ONE; 9(11):e113531.

Date published: November 24, 2014
Featured in this article: Michael Greenlief, Mark Hannink.

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A conserved motif mediates both multimer formation and allosteric activation of phosphoglycerate mutase 5. Wilkins JM, McConnell C, Tipton PA, Hannink M. Journal of Biological Chemistry; 289(36):25137-25148.

Date published: September 5, 2014
Featured in this article: Mark Hannink.

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Induction of heme oxygenase I (HMOX1) by HPP-4382: A novel modulator of bach1 activity. Attucks OC, Jasmer KJ, Hannink M, Kassis J, Zhong Z, Gupta S, Victory SF, Guzel M, Polisetti DR, Andrews R, Mjalli AMM, Kostura MJ. PLoS ONE; 9(7):e101044.

Date published: July 14, 2014
Featured in this article: Mark Hannink.

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2013

PiggyBac transposon plus insulators overcome epigenetic silencing to provide for stable signaling pathway reporter cell lines. Mossine VV, Waters JK, Hannink M, Mawhinney TP. PLoS ONE; 8(12):e85494.

Date published: December 20, 2013
Featured in this article: Mark Hannink.

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2012

Elongation Factor 1 alpha1 and Genes Associated with Usher Syndromes Are Downstream Targets of GBX2. Roeseler DA, Sachdev S, Buckley DM, Joshi T, Wu DK, Xu D, Hannink M, Waters ST. PLoS ONE; 7(11):e47366.

Date published: November 8, 2012
Featured in this article: Shrikesh C. "Rick" Sachdev, Trupti Joshi, Dong Xu, Mark Hannink.

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Gold Nanoparticle-Mediated Detection of Circulating Cancer Cells. Bhattacharyya K, Goldschmidt BS, Hannink M, Alexander S, Jurkevich A, Viator JA. Clinics in Laboratory Medicine; 32(1):89-101.

Date published: March 1, 2012
Featured in this article: Mark Hannink, Alexander Jurkevich.

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2011

Modulation of phototropic responsiveness in arabidopsis through ubiquitination of phototropin 1 by the CUL3-ring E3 ubiquitin ligase CRL3 NPH3. Roberts D, Pedmale UV, Morrow J, Sachdev S, Lechner E, Tang X, Zheng N, Hannink M, Genschik P, Liscum E. Plant Cell; 23(10):3627-3640.

Date published: December 1, 2011
Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink.

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2010

Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy. Cirak S, Von Deimling F, Sachdev S, Errington WJ, Herrmann R, Bönnemann C, Brockmann K, Hinderlich S, Lindner TH, Steinbrecher A, Hoffmann K, Privé GG, Hannink M, Nürnberg P, Voit T. Brain; 133(7):2123-2135.

Date published: July 1, 2010
Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink.

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Discovery of putative oocyte quality markers by comparative ExacTag proteomics. Powell MD, Manandhar G, Spate L, Sutovsky M, Zimmerman S, Sachdev SC, Hannink M, Prather RS, Sutovsky P. Proteomics - Clinical Applications; 4(3):337-351.

Date published: March 1, 2010
Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink.

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Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing. Sridevi P, Alexander H, Laviad EL, Min J, Mesika A, Hannink M, Futerman AH, Alexander S. Experimental Cell Research; 316(1):78-91.

Date published: January 1, 2010
Featured in this article: Mark Hannink.

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2009

Dihydro-CDDO-trifluoroethyl amide (dh404), A novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes. Ichikawa T, Li J, Meyer CJ, Janicki JS, Hannink M, Cui T. PLoS ONE; 4(12):e8391.

Date published: December 21, 2009
Featured in this article: Mark Hannink.

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Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. Eggler AL, Small E, Hannink M, Mesecar AD. Biochemical Journal; 422(1):171-180.

Date published: August 15, 2009
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Ceramide synthase 1 is regulated by proteasomal mediated turnover. Sridevi P, Alexander H, Laviad EL, Pewzner-Jung Y, Hannink M, Futerman AH, Alexander S. Biochimica et Biophysica Acta - Molecular Cell Research; 1793(7):1218-1227.

Date published: July 1, 2009
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2008

Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells. Westfall SD, Sachdev S, Das P, Hearne LB, Hannink M, Roberts RM, Ezashi T. Stem Cells and Development; 17(5):869-881.

Date published: October 1, 2008
Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink, Michael Roberts.

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Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli. Yu Z, Li P, Zhang M, Hannink M, Stamler JS, Yan Z. PLoS ONE; 3(5):e2086.

Date published: May 7, 2008
Featured in this article: Mark Hannink.

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PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. Lo S-C, Hannink M. Experimental Cell Research; 314(8):1789-1803.

Date published: May 1, 2008
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Molecular imaging of bcl-2 expression in small lymphocytic lymphoma using 111In-labeled PNA-peptide conjugates. Jia F, Figueroa SD, Gallazzi F, Balaji BS, Hannink M, Lever SZ, Hoffman TJ, Lewis MR. Journal of Nuclear Medicine; 49(3):430-438.

Date published: March 1, 2008
Featured in this article: Fabio Gallazzi, Mark Hannink.

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2007

ERRβ: A potent inhibitor of Nrf2 transcriptional activity. Zhou W, Lo S-C, Liu J-H, Hannink M, Lubahn DB. Molecular and Cellular Endocrinology; 278(1-2):52-62.

Date published: November 15, 2007
Featured in this article: Mark Hannink.

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Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival. Liu X-m, Peyton KJ, Ensenat D, Wang H, Hannink M, Alam J, Durante W. Cardiovascular Research; 75(2):381-389.

Date published: July 15, 2007
Featured in this article: Mark Hannink.

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Disruption of the Keap1-containing ubiquitination complex as an antioxidant therapy. Kern JT, Hannink M, Hess JF. Current Topics in Medicinal Chemistry; 7(10):972-978.

Date published: May 1, 2007
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2006

PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex. Lo S-C, Hannink M. Journal of Biological Chemistry; 281(49):37893-37903.

Date published: December 8, 2006
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Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling. Lo S-C, Li X, Henzl MT, Beamer LJ, Hannink M. EMBO Journal; 25(15):3605-3617.

Date published: August 9, 2006
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CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1. Lo S-C, Hannink M. Molecular and Cellular Biology; 26(4):1235-1244.

Date published: February 1, 2006
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2005

Repression of cancer protective genes by 17β-estradiol: Ligand-dependent interaction between human Nrf2 and estrogen receptor α. Ansell PJ, Lo S-C, Newton LG, Espinosa-Nicholas C, Zhang DD, Liu J-H, Hannink M, Lubahn DB. Molecular and Cellular Endocrinology; 243(1-2):27-34.

Date published: November 24, 2005
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Conserved solvent and side-chain interactions in the 1.35 Å structure of the Kelch domain of Keap1. Beamer LJ, Li X, Bottoms CA, Hannink M. Acta Crystallographica Section D: Biological Crystallography; 61(10):1335-1342.

Date published: October 1, 2005
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Distinct signaling pathways for induction of type II NOS by IFNγ and LPS in BV-2 microglial cells. Shen S, Yu S, Binek J, Chalimoniuk M, Zhang X, Lo S-C, Hannink M, Wu J, Fritsche K, Donato R, Sun GY. Neurochemistry International; 47(4):298-307.

Date published: September 1, 2005
Featured in this article: Mark Hannink.

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Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. Zhang DD, Lo S-C, Sun Z, Habib GM, Lieberman MW, Hannink M. Journal of Biological Chemistry; 280(34):30091-30099.

Date published: August 26, 2005
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Coordinate regulation of basal and cyclic 5′-adenosine monophosphate (cAMP)-activated expression of human chorionic gonadotropin-α by Ets-2 and cAMP-responsive element binding protein. Ghosh D, Sachdev S, Hannink M, Roberts RM. Molecular Endocrinology; 19(4):1049-1066.

Date published: April 1, 2005
Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink, Michael Roberts.

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2004

Crystal structure of the Kelch domain of human Keap1. Li X, Zhang D, Hannink M, Beamer LJ. Journal of Biological Chemistry; 279(52):54750-54758.

Date published: December 24, 2004
Featured in this article: Mark Hannink.

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Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Zhang DD, Lo S-C, Cross JV, Templeton DJ, Hannink M. Molecular and Cellular Biology; 24(24):10941-10953.

Date published: December 1, 2004
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Crystallization and initial crystallographic analysis of the Kelch domain from human Keap1. Li X, Zhang D, Hannink M, Beamer LJ. Acta Crystallographica Section D: Biological Crystallography; 60(12 II):2346-2348.

Date published: December 1, 2004
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In Vitro and in Vivo Regulation of Antioxidant Response Element-Dependent Gene Expression by Estrogens. Ansell PJ, Espinosa-Nicholas C, Curran EM, Judy BM, Philips BJ, Hannink M, Lubahn DB. Endocrinology; 145(1):311-317.

Date published: January 1, 2004
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2003

Synthesis of Radiometal-Labeled and Fluorescent Cell-Permeating Peptide-PNA Conjugates for Targeting the bcl-2 Proto-oncogene. Gallazzi F, Wang Y, Jia F, Shenoy N, Landon LA, Hannink M, Lever SZ, Lewis MR. Bioconjugate Chemistry; 14(6):1083-1095.

Date published: November 1, 2003
Featured in this article: Fabio Gallazzi, Mark Hannink.

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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress. Zhang DD, Hannink M. Molecular and Cellular Biology; 23(22):8137-8151.

Date published: November 1, 2003
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Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, Diehl JA. Molecular and Cellular Biology; 23(20):7198-7209.

Date published: October 1, 2003
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Molecular mechanisms that regulate transcription factor localization suggest new targets for drug development. Lee S-H, Hannink M. Advanced Drug Delivery Reviews; 55(6):717-731.

Date published: June 16, 2003
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2002

Radiometal-labeled peptide-PNA conjugates for targeting bcl-2 expression: Preparation, characterization, and in vitro mRNA binding. Lewis MR, Jia F, Gallazzi F, Wang Y, Zhang J, Shenoy N, Lever SZ, Hannink M. Bioconjugate Chemistry; 13(6):1176-1180.

Date published: November 1, 2002
Featured in this article: Fabio Gallazzi, Mark Hannink.

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CRM1-mediated nuclear export is present during porcine embryogenesis, but is not required for early cleavage. Cabot RA, Hannink M, Prather RS. Biology of Reproduction; 67(3):814-819.

Date published: September 3, 2002
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Characterization of the nuclear import and export functions of IκBε. Lee S-H, Hannink M. Journal of Biological Chemistry; 277(26):23358-23366.

Date published: June 28, 2002
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2001

The N-terminal Nuclear Export Sequence of IκBα Is Required for RanGTP-dependent Binding to CRM1. Lee S-H, Hannink M. Journal of Biological Chemistry; 276(26):23599-23606.

Date published: June 29, 2001
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2000

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Alt JR, Cleveland JL, Hannink M, Diehl JA. Genes and Development; 14(24):3102-3114.

Date published: December 15, 2000
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Nuclear import of IκBα is accomplished by a Ran-independent transport pathway. Sachdev S, Bagchi S, Zhang DD, Mings AC, Hannink M. Molecular and Cellular Biology; 20(5):1571-1582.

Date published: March 1, 2000
Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink.

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1999

Involvement of lipid mediators on cytokine signaling and induction of secretory phospholipase A2 in immortalized astrocytes (DITNC). Tong W, Shah D, Xu J, Diehl JA, Hans A, Hannink M, Sun GY. Journal of Molecular Neuroscience; 12(2):89-99.

Date published: April 1, 1999
Featured in this article: Mark Hannink.

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1998

Loss of IκBα-mediated control over nuclear import and DNA binding enables oncogenic activation of c-Rel. Sachdev S, Hannink M. Molecular and Cellular Biology; 18(9):5445-5456.

Date published: September 1, 1998
Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink.

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Nuclear localization of IκBα is mediated by the second ankyrin repeat: The IκBα ankyrin repeats define a novel class of cis-acting nuclear import sequences. Sachdev S, Hoffmann A, Hannink M. Molecular and Cellular Biology; 18(5):2524-2534.

Date published: May 1, 1998
Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink.

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Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptotic cell death in the embryonic vasculature with embryotoxicity. Cantrell SM, Joy-Schlezinger J, Stegeman JJ, Tillitt DE, Hannink M. Toxicology and Applied Pharmacology; 148(1):24-34.

Date published: January 1, 1998
Featured in this article: Mark Hannink.

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1997

A threshold nuclear level of the v-Rel oncoprotein is required for transformation of avian lymphocytes. Sachdev S, Diehl JA, McKinsey TA, Hans A, Hannink M. Oncogene; 14(21):2585-2594.

Date published: May 26, 1997
Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink.

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Adenovirus E3-10.4K/14.5K protein complex inhibits tumor necrosis factor-induced translocation of cytosolic phospholipase A2 to membranes. Dimitrov T, Krajcsi P, Hermiston TW, Tollefson AE, Hannink M, Wold WSM. Journal of Virology; 71(4):2830-2837.

Date published: April 1, 1997
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The ankyrin repeat domain of I KB a mediates nuclear shuttling reduced control by iicb-a over nuclear localization of rel proteins contributes to oncogenic activation. Sachdev S, Hannink M. FASEB Journal; 11(9):A1065.

Date published: January 1, 1997
Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink.

1996

Embryotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): The embryonic vasculature is a physiological target for TCDD-induced DNA damage and apoptotic cell death in medaka (Orizias latipes). Cantrell SM, Lutz LH, Tillitt DE, Hannink M. Toxicology and Applied Pharmacology; 141(1):23-34.

Date published: November 1, 1996
Featured in this article: Mark Hannink.

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The reverse two-hybrid system: A genetic scheme for selection against specific protein/protein interactions. Leanna CA, Hannink M. Nucleic Acids Research; 24(17):3341-3347.

Date published: September 1, 1996
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N-acetyl cysteine provides partial protection against TCDD-induced lethality in fish embryos. Cantrell SM, Hannink M, Tillitt D. Marine Environmental Research; 42(1-4):113-118.

Date published: June 1, 1996
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PEST-dependent cytoplasmic retention of v-Rel by IκB-α: Evidence that IκB-α regulates cellular localization of c-Rel and v-Rel by distinct mechanisms. Rottjakob EM, Sachdev S, Leanna CA, McKinsey TA, Hannink M. Journal of Virology; 70(5):3176-3188.

Date published: May 1, 1996
Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink.

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1995

Iκ-B-α-mediated inhibition of nuclear transport and DNA-binding by Rel proteins are separable functions: Phosphorylation of C-terminal serine residues of IκB-α is specifically required for inhibition of DNA-binding. Sachdev S, Rottjakob EM, Diehl JA, Hannink M. Oncogene; 11(5):811-823.

Date published: September 7, 1995
Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink.

Concerted participation of NF-κB and C/EBP heteromer in lipopolysaccharide induction of serum amyloid A gene expression in liver. Ray A, Hannink M, Ray BK. Journal of Biological Chemistry; 270(13):7365-7374.

Date published: March 31, 1995
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Tumor necrosis factor-α-dependent activation of a RelA homodimer in astrocytes: Increased phosphorylation of RelA and MAD-3 precede activation of RelA. Diehl JA, Tong W, Sun G, Hannink M. Journal of Biological Chemistry; 270(6):2703-2707.

Date published: February 10, 1995
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1994

Identification of a C/EBP-Rel complex in avian lymphoid cells. Diehl JA, Hannink M. Molecular and Cellular Biology; 14(10):6635-6646.

Date published: October 1, 1994
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1993

Heterologous C-terminal sequences disrupt transcriptional activation and oncogenesis by p59(v-rel). Diehl JA, Hannink M. Journal of Virology; 67(12):7161-7171.

Date published: December 1, 1993
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Differential pp40(IκB-β) inhibition of DNA binding by rel proteins. Diehl JA, McKinsey TA, Hannink M. Molecular and Cellular Biology; 13(3):1769-1778.

Date published: March 1, 1993
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1992

The v-rel oncogene: Insights into the mechanism of transcriptional activation, repression, and transformation. Walker WH, Stein B, Ganchi PA, Hoffman JA, Kaufman PA, Ballard DW, Hannink M, Greene WC. Journal of Virology; 66(8):5018-5029.

Date published: August 1, 1992
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1991

Molecular mechanisms of transformation by the v-rel oncogene. Hannink M, Temin HM. Critical reviews in oncogenesis; 2(4):293-309.

Date published: January 1, 1991
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1990

The v-rel oncogene encodes a κB enhancer binding protein that inhibits NF-κB function. Ballard DW, Walker WH, Doerre S, Sista P, Molitor JA, Dixon EP, Peffer NJ, Hannink M, Greene WC. Cell; 63(4):803-814.

Date published: November 16, 1990
Featured in this article: Mark Hannink.

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Structure and autoregulation of the c-rel promoter. Hannink M, Temin HM. Oncogene; 5(12):1843-1850.

Date published: January 1, 1990
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1989

Transactivation of gene expression by nuclear and cytoplasmic rel proteins. Hannink M, Temin HM. Molecular and Cellular Biology; 9(10):4323-4336.

Date published: October 1, 1989
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Structure and function of platelet-derived growth factor (PDGF) and related proteins. Hannink M, Donoghue DJ. BBA - Reviews on Cancer; 989(1):1-10.

Date published: July 28, 1989
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1988

Autocrine stimulation by the v-sis gene product requires a ligand-receptor interaction at the cell surface. Hannink M, Donoghue DJ. Journal of Cell Biology; 107(1):287-298.

Date published: July 1, 1988
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The histidine-221 to tyrosine substitution in v-mos abolishes its biological function and its protein kinase activity. Singh B, Wittenberg C, Hannink M, Reed SI, Donoghue DJ, Arlinghaus RB. Virology; 164(1):114-120.

Date published: May 1, 1988
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1987

Identification of a signal for nuclear targeting in platelet-derived-growth-factor-related molecules. Lee BA, Maher DW, Hannink M, Donoghue DJ. Molecular and Cellular Biology; 7(10):3527-3537.

Date published: October 1, 1987
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1986

p37(mos)-Associated serine/threonine protein kinase activity correlates with the cellular transformation function of v-mos. Singh B, Hannink M, Donoghue DJ, Arlinghaus RB. Journal of Virology; 60(3):1148-1152.

Date published: December 1, 1986
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Cell surface expression of membrane-anchored v-sis gene products: Glycosylation is not required for cell surface transport. Hannink M, Donoghue DJ. Journal of Cell Biology; 103(6):2311-2322.

Date published: December 1, 1986
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Deletions in the N-terminal coding region of the v-sis gene: Determination of the minimal transforming region. Sauer MK, Hannink M, Donoghue DJ. Journal of Virology; 59(2):292-300.

Date published: August 1, 1986
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Deletions in the C-terminal coding region of the v-sis gene: Dimerization is required for transformation. Hannink M, Sauer MK, Donoghue DJ. Molecular and Cellular Biology; 6(4):1304-1314.

Date published: April 1, 1986
Featured in this article: Mark Hannink.

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Biosynthesis of the v-sis gene product: Signal sequence cleavage, glycosylation, and proteolytic processing. Hannink M, Donoghue DJ. Molecular and Cellular Biology; 6(4):1343-1348.

Date published: April 1, 1986
Featured in this article: Mark Hannink.

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Functions of the mos oncogene family and associated gene products. Bold RJ, Hannink M, Donoghue DJ. Cancer Surveys; 5(2):243-255.

Date published: January 1, 1986
Featured in this article: Mark Hannink.

1985

Lysine residue 121 in the proposed ATP-binding site of the v-mos protein is required for transformation. Hannink M, Donoghue DJ. Proceedings of the National Academy of Sciences of the United States of America; 82(23):7894-7898.

Date published: December 1, 1985
Featured in this article: Mark Hannink.

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1984

Requirement for a signal sequence in biological expression of the v-sis oncogene. Hannink M, Donoghue DJ. Science; 226(4679):1197-1199.

Date published: December 7, 1984
Featured in this article: Mark Hannink.

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