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Mark Hannink

Mark Hannink

Professor, Biochemistry

Phone: 573-882-7971
hanninkm@missouri.edu
440e Bond Life Sciences Center

Mark Hannick is a professor of biochemistry. The Hannink laboratory studies the molecular mechanisms that regulate how cells respond to their environment. In particular, his lab is interested in understanding how human cells sense and respond to oxidative stress. Oxidative stress has been implicated in many disease processes, including cancer, heart failure, kidney disease, liver disease and neurodegenerative diseases such as Parkinson’s and Alzheimer’s. Oxidative stress results from an imbalance between highly reactive oxygen molecules produced by normal cellular processes and the anti-oxidant molecules that help cells neutralize and eliminate reactive and toxic molecules. The Hannink lab has identified several protein complexes that regulate cellular responses to oxidative stress and is interested in developing therapeutic approaches that target these protein complexes and will increase the ability of normal cells to withstand oxidative stress.

News about Mark Hannink

Research Topics

Heme oxygenase promotes B-Raf-dependent melanosphere formation. Jasmer KJ, Hou J, Mannino P, Cheng J, Hannink M. Pigment Cell and Melanoma Research; 33(6):850-868.

Featured in this article: Kimberly Jasmer, Mark Hannink.

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Nrf2-inducing and HMG-CoA reductase inhibitory activities of a polyphenol-rich fraction of Guazuma ulmifolia leaves. Sulistiyani S, Falah S, Wahyuni W, Andrianto D, Lelono A, Nurcholis W, Mossine V, Hannink M. Asian Pacific Journal of Tropical Biomedicine; 9(9):389-396.

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Effects of moloney leukemia virus 10 protein on hepatitis B virus infection and viral replication. Puray-Chavez MN, Farghali MH, Yapo V, Huber AD, Liu D, Ndongwe TP, Casey MC, Laughlin T, Hannink M, Tedbury PR, Sarafianos SG. Viruses; 11(7):651.

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Exploring the molecular genetic foundations of cancer biology and how biomedical advances are made in an advanced undergraduate course. Alexander S, Hannink M. Biochemistry and Molecular Biology Education; 47(4):408-416.

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HDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 target gene expression. Hu T, Schreiter FC, Bagchi RA, Tatman PD, Hannink M, McKinsey TA. Journal of Biological Chemistry; 294(21):8640-8652.

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Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases. Sun GY, Simonyi A, Fritsche KL, Chuang DY, Hannink M, Gu Z, Greenlief CM, Yao JK, Lee JC, Beversdorf DQ. Prostaglandins Leukotrienes and Essential Fatty Acids; 136:3-13.

Featured in this article: Mark Hannink, Michael Greenlief.

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Assembly of PGAM5 into Multimeric Complexes Provides a Mechanism for Allosteric Regulation of Phosphatase Activity. Tipton P, Su T, Hannink M. Methods in Enzymology; 607:353-372.

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Cancer as a mutation-driven evolutionary process. Hannink M, Temin HM. Growth Regulation and Carcinogenesis: Volume I; 95-97.

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Mutation-driven evolution of rev-T. Hannink M, Temin HM. Growth Regulation and Carcinogenesis: Volume I; 99-109.

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Withania somnifera and Its Withanolides Attenuate Oxidative and Inflammatory Responses and Up-Regulate Antioxidant Responses in BV-2 Microglial Cells. Sun GY, Li R, Cui J, Hannink M, Gu Z, Fritsche KL, Lubahn DB, Simonyi A. NeuroMolecular Medicine; 18(3):241-252.

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Phytochemicals and botanical extracts regulate NF-κB and Nrf2/ARE reporter activities in di TNC1 astrocytes. Ajit D, Simonyi A, Li R, Chen Z, Hannink M, Fritsche KL, Mossine VV, Smith RE, Dobbs TK, Luo R, Folk WR, Gu Z, Lubahn DB, Weisman GA, Sun GY. Neurochemistry International; 97:49-56.

Featured in this article: Mark Hannink, Gary Weisman.

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Quercetin attenuates inflammatory responses in BV-2 microglial cells: Role of MAPKs on the Nrf2 pathway and induction of heme oxygenase-1. Sun GY, Chen Z, Jasmer KJ, Chuang DY, Gu Z, Hannink M, Simonyi A. PLoS ONE; 10(10):e0141509.

Featured in this article: Kimberly Jasmer, Mark Hannink.

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From gigabyte to kilobyte: A bioinformatics protocol for mining large RNA-Seq transcriptomics data. Li J, Hou J, Sun L, Wilkins JM, Lu Y, Niederhuth CE, Merideth BR, Mawhinney TP, Mossine VV, Greenlief CM, Walker JC, Folk WR, Hannink M, Lubahn DB, Birchler JA, Cheng J. PLoS ONE; 10(4):e0125000.

Featured in this article: Michael Greenlief, Mark Hannink.

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Proteomic analysis of the effects of aged garlic extract and its FruArg component on lipopolysaccharide-induced neuroinflammatory response in microglial cells. Zhou H, Qu Z, Mossine VV, Nknolise DL, Li J, Chen Z, Cheng J, Greenlief CM, Mawhinney TP, Brown PN, Fritsche KL, Hannink M, Lubahn DB, Sun GY, Gu Z. PLoS ONE; 9(11):e113531.

Featured in this article: Michael Greenlief, Mark Hannink.

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A conserved motif mediates both multimer formation and allosteric activation of phosphoglycerate mutase 5. Wilkins JM, McConnell C, Tipton PA, Hannink M. Journal of Biological Chemistry; 289(36):25137-25148.

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Induction of heme oxygenase I (HMOX1) by HPP-4382: A novel modulator of bach1 activity. Attucks OC, Jasmer KJ, Hannink M, Kassis J, Zhong Z, Gupta S, Victory SF, Guzel M, Polisetti DR, Andrews R, Mjalli AMM, Kostura MJ. PLoS ONE; 9(7):e101044.

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PiggyBac transposon plus insulators overcome epigenetic silencing to provide for stable signaling pathway reporter cell lines. Mossine VV, Waters JK, Hannink M, Mawhinney TP. PLoS ONE; 8(12):e85494.

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Elongation Factor 1 alpha1 and Genes Associated with Usher Syndromes Are Downstream Targets of GBX2. Roeseler DA, Sachdev S, Buckley DM, Joshi T, Wu DK, Xu D, Hannink M, Waters ST. PLoS ONE; 7(11):e47366.

Featured in this article: Shrikesh C. "Rick" Sachdev, Trupti Joshi, Dong Xu, Mark Hannink.

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Gold Nanoparticle-Mediated Detection of Circulating Cancer Cells. Bhattacharyya K, Goldschmidt BS, Hannink M, Alexander S, Jurkevich A, Viator JA. Clinics in Laboratory Medicine; 32(1):89-101.

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Modulation of phototropic responsiveness in arabidopsis through ubiquitination of phototropin 1 by the CUL3-ring E3 ubiquitin ligase CRL3 NPH3. Roberts D, Pedmale UV, Morrow J, Sachdev S, Lechner E, Tang X, Zheng N, Hannink M, Genschik P, Liscum E. Plant Cell; 23(10):3627-3640.

Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink.

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Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy. Cirak S, Von Deimling F, Sachdev S, Errington WJ, Herrmann R, Bönnemann C, Brockmann K, Hinderlich S, Lindner TH, Steinbrecher A, Hoffmann K, Privé GG, Hannink M, Nürnberg P, Voit T. Brain; 133(7):2123-2135.

Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink.

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Discovery of putative oocyte quality markers by comparative ExacTag proteomics. Powell MD, Manandhar G, Spate L, Sutovsky M, Zimmerman S, Sachdev SC, Hannink M, Prather RS, Sutovsky P. Proteomics - Clinical Applications; 4(3):337-351.

Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink.

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Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing. Sridevi P, Alexander H, Laviad EL, Min J, Mesika A, Hannink M, Futerman AH, Alexander S. Experimental Cell Research; 316(1):78-91.

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Dihydro-CDDO-trifluoroethyl amide (dh404), A novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes. Ichikawa T, Li J, Meyer CJ, Janicki JS, Hannink M, Cui T. PLoS ONE; 4(12):e8391.

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Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. Eggler AL, Small E, Hannink M, Mesecar AD. Biochemical Journal; 422(1):171-180.

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Ceramide synthase 1 is regulated by proteasomal mediated turnover. Sridevi P, Alexander H, Laviad EL, Pewzner-Jung Y, Hannink M, Futerman AH, Alexander S. Biochimica et Biophysica Acta - Molecular Cell Research; 1793(7):1218-1227.

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Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells. Westfall SD, Sachdev S, Das P, Hearne LB, Hannink M, Roberts RM, Ezashi T. Stem Cells and Development; 17(5):869-881.

Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink, Michael Roberts, Toshihiko Ezashi.

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Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli. Yu Z, Li P, Zhang M, Hannink M, Stamler JS, Yan Z. PLoS ONE; 3(5):e2086.

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PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. Lo S-C, Hannink M. Experimental Cell Research; 314(8):1789-1803.

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Molecular imaging of bcl-2 expression in small lymphocytic lymphoma using 111In-labeled PNA-peptide conjugates. Jia F, Figueroa SD, Gallazzi F, Balaji BS, Hannink M, Lever SZ, Hoffman TJ, Lewis MR. Journal of Nuclear Medicine; 49(3):430-438.

Featured in this article: Fabio Gallazzi, Mark Hannink.

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ERRβ: A potent inhibitor of Nrf2 transcriptional activity. Zhou W, Lo S-C, Liu J-H, Hannink M, Lubahn DB. Molecular and Cellular Endocrinology; 278(1-2):52-62.

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Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival. Liu X-m, Peyton KJ, Ensenat D, Wang H, Hannink M, Alam J, Durante W. Cardiovascular Research; 75(2):381-389.

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Disruption of the Keap1-containing ubiquitination complex as an antioxidant therapy. Kern JT, Hannink M, Hess JF. Current Topics in Medicinal Chemistry; 7(10):972-978.

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PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex. Lo S-C, Hannink M. Journal of Biological Chemistry; 281(49):37893-37903.

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Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling. Lo S-C, Li X, Henzl MT, Beamer LJ, Hannink M. EMBO Journal; 25(15):3605-3617.

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CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1. Lo S-C, Hannink M. Molecular and Cellular Biology; 26(4):1235-1244.

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Repression of cancer protective genes by 17β-estradiol: Ligand-dependent interaction between human Nrf2 and estrogen receptor α. Ansell PJ, Lo S-C, Newton LG, Espinosa-Nicholas C, Zhang DD, Liu J-H, Hannink M, Lubahn DB. Molecular and Cellular Endocrinology; 243(1-2):27-34.

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Conserved solvent and side-chain interactions in the 1.35 Å structure of the Kelch domain of Keap1. Beamer LJ, Li X, Bottoms CA, Hannink M. Acta Crystallographica Section D: Biological Crystallography; 61(10):1335-1342.

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Distinct signaling pathways for induction of type II NOS by IFNγ and LPS in BV-2 microglial cells. Shen S, Yu S, Binek J, Chalimoniuk M, Zhang X, Lo S-C, Hannink M, Wu J, Fritsche K, Donato R, Sun GY. Neurochemistry International; 47(4):298-307.

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Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. Zhang DD, Lo S-C, Sun Z, Habib GM, Lieberman MW, Hannink M. Journal of Biological Chemistry; 280(34):30091-30099.

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Coordinate regulation of basal and cyclic 5′-adenosine monophosphate (cAMP)-activated expression of human chorionic gonadotropin-α by Ets-2 and cAMP-responsive element binding protein. Ghosh D, Sachdev S, Hannink M, Roberts RM. Molecular Endocrinology; 19(4):1049-1066.

Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink, Michael Roberts.

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Crystal structure of the Kelch domain of human Keap1. Li X, Zhang D, Hannink M, Beamer LJ. Journal of Biological Chemistry; 279(52):54750-54758.

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Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Zhang DD, Lo S-C, Cross JV, Templeton DJ, Hannink M. Molecular and Cellular Biology; 24(24):10941-10953.

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Crystallization and initial crystallographic analysis of the Kelch domain from human Keap1. Li X, Zhang D, Hannink M, Beamer LJ. Acta Crystallographica Section D: Biological Crystallography; 60(12 II):2346-2348.

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In Vitro and in Vivo Regulation of Antioxidant Response Element-Dependent Gene Expression by Estrogens. Ansell PJ, Espinosa-Nicholas C, Curran EM, Judy BM, Philips BJ, Hannink M, Lubahn DB. Endocrinology; 145(1):311-317.

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Synthesis of Radiometal-Labeled and Fluorescent Cell-Permeating Peptide-PNA Conjugates for Targeting the bcl-2 Proto-oncogene. Gallazzi F, Wang Y, Jia F, Shenoy N, Landon LA, Hannink M, Lever SZ, Lewis MR. Bioconjugate Chemistry; 14(6):1083-1095.

Featured in this article: Fabio Gallazzi, Mark Hannink.

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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress. Zhang DD, Hannink M. Molecular and Cellular Biology; 23(22):8137-8151.

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Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, Diehl JA. Molecular and Cellular Biology; 23(20):7198-7209.

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Molecular mechanisms that regulate transcription factor localization suggest new targets for drug development. Lee S-H, Hannink M. Advanced Drug Delivery Reviews; 55(6):717-731.

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Radiometal-labeled peptide-PNA conjugates for targeting bcl-2 expression: Preparation, characterization, and in vitro mRNA binding. Lewis MR, Jia F, Gallazzi F, Wang Y, Zhang J, Shenoy N, Lever SZ, Hannink M. Bioconjugate Chemistry; 13(6):1176-1180.

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CRM1-mediated nuclear export is present during porcine embryogenesis, but is not required for early cleavage. Cabot RA, Hannink M, Prather RS. Biology of Reproduction; 67(3):814-819.

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Characterization of the nuclear import and export functions of IκBε. Lee S-H, Hannink M. Journal of Biological Chemistry; 277(26):23358-23366.

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The N-terminal Nuclear Export Sequence of IκBα Is Required for RanGTP-dependent Binding to CRM1. Lee S-H, Hannink M. Journal of Biological Chemistry; 276(26):23599-23606.

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Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Alt JR, Cleveland JL, Hannink M, Diehl JA. Genes and Development; 14(24):3102-3114.

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Nuclear import of IκBα is accomplished by a Ran-independent transport pathway. Sachdev S, Bagchi S, Zhang DD, Mings AC, Hannink M. Molecular and Cellular Biology; 20(5):1571-1582.

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Involvement of lipid mediators on cytokine signaling and induction of secretory phospholipase A2 in immortalized astrocytes (DITNC). Tong W, Shah D, Xu J, Diehl JA, Hans A, Hannink M, Sun GY. Journal of Molecular Neuroscience; 12(2):89-99.

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Loss of IκBα-mediated control over nuclear import and DNA binding enables oncogenic activation of c-Rel. Sachdev S, Hannink M. Molecular and Cellular Biology; 18(9):5445-5456.

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Nuclear localization of IκBα is mediated by the second ankyrin repeat: The IκBα ankyrin repeats define a novel class of cis-acting nuclear import sequences. Sachdev S, Hoffmann A, Hannink M. Molecular and Cellular Biology; 18(5):2524-2534.

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Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptotic cell death in the embryonic vasculature with embryotoxicity. Cantrell SM, Joy-Schlezinger J, Stegeman JJ, Tillitt DE, Hannink M. Toxicology and Applied Pharmacology; 148(1):24-34.

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A threshold nuclear level of the v-Rel oncoprotein is required for transformation of avian lymphocytes. Sachdev S, Diehl JA, McKinsey TA, Hans A, Hannink M. Oncogene; 14(21):2585-2594.

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Adenovirus E3-10.4K/14.5K protein complex inhibits tumor necrosis factor-induced translocation of cytosolic phospholipase A2 to membranes. Dimitrov T, Krajcsi P, Hermiston TW, Tollefson AE, Hannink M, Wold WSM. Journal of Virology; 71(4):2830-2837.

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The ankyrin repeat domain of I KB a mediates nuclear shuttling reduced control by iicb-a over nuclear localization of rel proteins contributes to oncogenic activation. Sachdev S, Hannink M. FASEB Journal; 11(9):A1065.

Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink.

Embryotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): The embryonic vasculature is a physiological target for TCDD-induced DNA damage and apoptotic cell death in medaka (Orizias latipes). Cantrell SM, Lutz LH, Tillitt DE, Hannink M. Toxicology and Applied Pharmacology; 141(1):23-34.

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The reverse two-hybrid system: A genetic scheme for selection against specific protein/protein interactions. Leanna CA, Hannink M. Nucleic Acids Research; 24(17):3341-3347.

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N-acetyl cysteine provides partial protection against TCDD-induced lethality in fish embryos. Cantrell SM, Hannink M, Tillitt D. Marine Environmental Research; 42(1-4):113-118.

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PEST-dependent cytoplasmic retention of v-Rel by IκB-α: Evidence that IκB-α regulates cellular localization of c-Rel and v-Rel by distinct mechanisms. Rottjakob EM, Sachdev S, Leanna CA, McKinsey TA, Hannink M. Journal of Virology; 70(5):3176-3188.

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Iκ-B-α-mediated inhibition of nuclear transport and DNA-binding by Rel proteins are separable functions: Phosphorylation of C-terminal serine residues of IκB-α is specifically required for inhibition of DNA-binding. Sachdev S, Rottjakob EM, Diehl JA, Hannink M. Oncogene; 11(5):811-823.

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Concerted participation of NF-κB and C/EBP heteromer in lipopolysaccharide induction of serum amyloid A gene expression in liver. Ray A, Hannink M, Ray BK. Journal of Biological Chemistry; 270(13):7365-7374.

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Tumor necrosis factor-α-dependent activation of a RelA homodimer in astrocytes: Increased phosphorylation of RelA and MAD-3 precede activation of RelA. Diehl JA, Tong W, Sun G, Hannink M. Journal of Biological Chemistry; 270(6):2703-2707.

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Identification of a C/EBP-Rel complex in avian lymphoid cells. Diehl JA, Hannink M. Molecular and Cellular Biology; 14(10):6635-6646.

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Heterologous C-terminal sequences disrupt transcriptional activation and oncogenesis by p59(v-rel). Diehl JA, Hannink M. Journal of Virology; 67(12):7161-7171.

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Differential pp40(IκB-β) inhibition of DNA binding by rel proteins. Diehl JA, McKinsey TA, Hannink M. Molecular and Cellular Biology; 13(3):1769-1778.

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The v-rel oncogene: Insights into the mechanism of transcriptional activation, repression, and transformation. Walker WH, Stein B, Ganchi PA, Hoffman JA, Kaufman PA, Ballard DW, Hannink M, Greene WC. Journal of Virology; 66(8):5018-5029.

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Molecular mechanisms of transformation by the v-rel oncogene. Hannink M, Temin HM. Critical reviews in oncogenesis; 2(4):293-309.

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The v-rel oncogene encodes a κB enhancer binding protein that inhibits NF-κB function. Ballard DW, Walker WH, Doerre S, Sista P, Molitor JA, Dixon EP, Peffer NJ, Hannink M, Greene WC. Cell; 63(4):803-814.

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Structure and autoregulation of the c-rel promoter. Hannink M, Temin HM. Oncogene; 5(12):1843-1850.

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Transactivation of gene expression by nuclear and cytoplasmic rel proteins. Hannink M, Temin HM. Molecular and Cellular Biology; 9(10):4323-4336.

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Structure and function of platelet-derived growth factor (PDGF) and related proteins. Hannink M, Donoghue DJ. BBA - Reviews on Cancer; 989(1):1-10.

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Autocrine stimulation by the v-sis gene product requires a ligand-receptor interaction at the cell surface. Hannink M, Donoghue DJ. Journal of Cell Biology; 107(1):287-298.

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The histidine-221 to tyrosine substitution in v-mos abolishes its biological function and its protein kinase activity. Singh B, Wittenberg C, Hannink M, Reed SI, Donoghue DJ, Arlinghaus RB. Virology; 164(1):114-120.

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Identification of a signal for nuclear targeting in platelet-derived-growth-factor-related molecules. Lee BA, Maher DW, Hannink M, Donoghue DJ. Molecular and Cellular Biology; 7(10):3527-3537.

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p37(mos)-Associated serine/threonine protein kinase activity correlates with the cellular transformation function of v-mos. Singh B, Hannink M, Donoghue DJ, Arlinghaus RB. Journal of Virology; 60(3):1148-1152.

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Cell surface expression of membrane-anchored v-sis gene products: Glycosylation is not required for cell surface transport. Hannink M, Donoghue DJ. Journal of Cell Biology; 103(6):2311-2322.

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Deletions in the N-terminal coding region of the v-sis gene: Determination of the minimal transforming region. Sauer MK, Hannink M, Donoghue DJ. Journal of Virology; 59(2):292-300.

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Deletions in the C-terminal coding region of the v-sis gene: Dimerization is required for transformation. Hannink M, Sauer MK, Donoghue DJ. Molecular and Cellular Biology; 6(4):1304-1314.

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Biosynthesis of the v-sis gene product: Signal sequence cleavage, glycosylation, and proteolytic processing. Hannink M, Donoghue DJ. Molecular and Cellular Biology; 6(4):1343-1348.

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Functions of the mos oncogene family and associated gene products. Bold RJ, Hannink M, Donoghue DJ. Cancer Surveys; 5(2):243-255.

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Lysine residue 121 in the proposed ATP-binding site of the v-mos protein is required for transformation. Hannink M, Donoghue DJ. Proceedings of the National Academy of Sciences of the United States of America; 82(23):7894-7898.

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Requirement for a signal sequence in biological expression of the v-sis oncogene. Hannink M, Donoghue DJ. Science; 226(4679):1197-1199.

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