Skip to navigation Skip to sub-navigation Skip to content

People

R. Michael Roberts

R. Michael Roberts

Curators’ Professor, Animal Sciences and Biochemistry Member, National Academy of Sciences

Phone: 573-882-0908
RobertsRM@missouri.edu
240b Life Sciences Center

Roberts, a reproductive biologist, in the past concentrated on early pregnancy in farm species, but in recent years he has transitioned to studying stem cells in relation to early development of the human placenta. He is currently exploring the causes of preeclampsia, a condition that, worldwide, kills thousands of pregnant women and their unborn babies each year. He is also involved in developing a line of stem cells for use in research with pigs; this effort is expected to expedite breakthroughs in using stem cells to regenerate retinal, heart and other tissues. Much of Roberts’ current work uses new “induced pluripotent stem cell” technology, which creates stem cells from a patient’s or animal’s own body tissue, such as skin. In many cases, this new method is replacing the older and more controversial embryonic stem cell technology.

News about R. Michael Roberts

2021

The immunology of syncytialized trophoblast. Schust DJ, Bonney EA, Sugimoto J, Ezashi T, Roberts RM, Choi S, Zhou J. International Journal of Molecular Sciences; 22(4):1-16.

Date published: February 2, 2021
Featured in this article: Toshihiko Ezashi, Michael Roberts, Sehee Choi, Jie Zhou.

Go to article...

Syncytins expressed in human placental trophoblast. Roberts RM, Ezashi T, Schulz LC, Sugimoto J, Schust DJ, Khan T, Zhou J. Placenta; In press.

Date published: January 15, 2021
Featured in this article: Michael Roberts, Toshihiko Ezashi, Teka Khan, Jie Zhou.

Go to article...

2020

Use of a human embryonic stem cell model to discover GABRP, WFDC2, VTCN1 and ACTC1 as markers of early first trimester human trophoblast. Karvas RM, McInturf S, Zhou J, Ezashi T, Schust DJ, Roberts RM, Schulz LC. Molecular Human Reproduction; 26(6):425-440.

Date published: April 1, 2020
Featured in this article: Jie Zhou, Toshihiko Ezashi, Michael Roberts.

Go to article...

2019

A six-inhibitor culture medium for improving naïve-type pluripotency of porcine pluripotent stem cells. Yuan Y, Park J, Tian Y, Choi J, Pasquariello R, Alexenko AP, Dai A, Behura SK, Roberts RM, Ezashi T. Cell Death Discovery; 5(1):104.

Date published: December 1, 2019
Featured in this article: YuChen Tian, Michael Roberts, Toshihiko Ezashi.

Go to article...

Early onset preeclampsia in a model for human placental trophoblast. Sheridan MA, Yang Y, Jain A, Lyons AS, Yang P, Brahmasani SR, Dai A, Tian Y, Ellersieck MR, Tuteja G, Schust DJ, Schulz LC, Ezashi T, Michael Roberts R. Proceedings of the National Academy of Sciences of the United States of America; 116(10):4336-4345.

Date published: February 20, 2019
Featured in this article: YuChen Tian, Toshihiko Ezashi, Michael Roberts.

Go to article...

2017

Quadrupling efficiency in production of genetically modified pigs through improved oocyte maturation. Yuan Y, Spate LD, Redel BK, Tian Y, Zhou J, Prather RS, Roberts RM. Proceedings of the National Academy of Sciences of the United States of America; 114(29):E5796-E5804.

Date published: July 18, 2017
Featured in this article: YuChen Tian, Jie Zhou, Michael Roberts.

Go to article...

2016

Efficient long-term cryopreservation of pluripotent stem cells at-80 °c. Yuan Y, Yang Y, Tian Y, Park J, Dai A, Roberts RM, Liu Y, Han X. Scientific Reports; 6:34476.

Date published: October 3, 2016
Featured in this article: YuChen Tian, Michael Roberts.

Go to article...

2012

Effect of maternal obesity on estrous cyclicity, embryo development and blastocyst gene expression in a mouse model. Bermejo-Alvarez P, Rosenfeld CS, Roberts RM. Human Reproduction; 27(12):3513-3522.

Date published: December 1, 2012
Featured in this article: Cheryl Rosenfeld, Michael Roberts.

Go to article...

2011

Disruption of adult expression of sexually selected traits by developmental exposure to bisphenol A. Jašarevića E, Sieli PT, Twellman EE, Welsh TH Jr, Schachtman TR, Roberts RM, Geary DC, Rosenfeld CS. Proceedings of the National Academy of Sciences of the United States of America; 108(28):11715-11720.

Date published: July 12, 2011
Featured in this article: Michael Roberts, Cheryl Rosenfeld.

Go to article...

2009

Derivation of induced pluripotent stem cells from pig somatic cells. Ezashi T, Telugu BPVL, Alexenko AP, Sachdev S, Sinha S, Roberts RM. Proceedings of the National Academy of Sciences of the United States of America; 106(27):10993-10998.

Date published: July 7, 2009
Featured in this article: Toshihiko Ezashi, Shrikesh C. "Rick" Sachdev, Michael Roberts.

Go to article...

2008

Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells. Westfall SD, Sachdev S, Das P, Hearne LB, Hannink M, Roberts RM, Ezashi T. Stem Cells and Development; 17(5):869-881.

Date published: October 1, 2008
Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink, Michael Roberts, Toshihiko Ezashi.

Go to article...

Effects of diets enriched in omega-3 and omega-6 polyunsaturated fatty acids on offspring sex-ratio and maternal behavior in mice. Fountain ED, Mao J, Whyte JJ, Mueller KE, Ellersieck MR, Will MJ, Roberts RM, MacDonald R, Rosenfeld CS. Biology of Reproduction; 78(2):211-217.

Date published: February 1, 2008
Featured in this article: Jiude Mao, Michael Roberts, Cheryl Rosenfeld.

Go to article...

2007

The contrasting effects of Ad libitum and restricted feeding of a diet very high in saturated fats on sex ratio and metabolic hormones in mice. Alexenko AP, Mao J, Ellersieck MR, Davis AM, Whyte JJ, Rosenfeld CS, Roberts RM. Biology of Reproduction; 77(4):599-604.

Date published: October 1, 2007
Featured in this article: Jiude Mao, Cheryl Rosenfeld, Michael Roberts.

Go to article...

Fluorescent in situ hybridization for sex chromosome determination before and after fertilization in mice. Whyte JJ, Roberts RM, Rosenfeld CS. Theriogenology; 67(5):1022-1031.

Date published: March 15, 2007
Featured in this article: Michael Roberts, Cheryl Rosenfeld.

Go to article...

2006

Effect of interferon-τ administration on endometrium of nonpregnant ewes: A comparison with pregnant ewes. Chen Y, Green JA, Antoniou E, Ealy AD, Mathialagan N, Walker AM, Avalle MP, Rosenfeld CS, Hearne LB, Roberts RM. Endocrinology; 147(5):2127-2137.

Date published: May 1, 2006
Featured in this article: Cheryl Rosenfeld, Michael Roberts.

Go to article...

2005

Coordinate regulation of basal and cyclic 5′-adenosine monophosphate (cAMP)-activated expression of human chorionic gonadotropin-α by Ets-2 and cAMP-responsive element binding protein. Ghosh D, Sachdev S, Hannink M, Roberts RM. Molecular Endocrinology; 19(4):1049-1066.

Date published: April 1, 2005
Featured in this article: Shrikesh C. "Rick" Sachdev, Mark Hannink, Michael Roberts.

Go to article...

2004

Maternal diet and other factors affecting offspring sex ratio: A review. Rosenfeld CS, Roberts RM. Biology of Reproduction; 71(4):1063-1070.

Date published: October 1, 2004
Featured in this article: Cheryl Rosenfeld, Michael Roberts.

Go to article...

2003

Striking variation in the sex ratio of pups born to mice according to whether maternal diet is high in fat or carbohydrate. Rosenfeld CS, Grimm KM, Livingston KA, Brokman AM, Lamberson WE, Roberts RM. Proceedings of the National Academy of Sciences of the United States of America; 100(8):4628-4632.

Date published: April 15, 2003
Featured in this article: Cheryl Rosenfeld, Michael Roberts.

Go to article...

Evolution of the interferon tau genes and their promoters, and maternal-trophoblast interactions in control of their expression. Roberts RM, Ezashi T, Rosenfeld CS, Ealy AD, Kubisch HM. Reproduction (Cambridge, England) Supplement; 61:239-251.

Date published: January 1, 2003
Featured in this article: Michael Roberts, Toshihiko Ezashi, Cheryl Rosenfeld.

2002

Expression of interferon receptor subunits, IFNAR1 and IFNAR2, in the ovine uterus. Rosenfeld CS, Han C-S, Alexenko AP, Spencer TE, Roberts RM. Biology of Reproduction; 67(3):847-853.

Date published: September 1, 2002
Featured in this article: Cheryl Rosenfeld, Michael Roberts.

Go to article...

2001

An aspartic proteinase expressed in the yolk sac and neonatal stomach of the mouse. Chen X, Rosenfeld CS, Roberts RM, Green JA. Biology of Reproduction; 65(4):1092-1101.

Date published: October 1, 2001
Featured in this article: Cheryl Rosenfeld, Michael Roberts.

Go to article...

Intraovarian actions of oestrogen. Rosenfeld CS, Wagner JS, Roberts RM, Lubahn DB. Reproduction; 122(2):215-226.

Date published: August 1, 2001
Featured in this article: Cheryl Rosenfeld, Michael Roberts.

Go to article...

Estrogen receptor- and aromatase-deficient mice provide insight into the roles of estrogen within the ovary and uterus. Rosenfeld CS, Michael Roberts R, Lubahn DB. Molecular Reproduction and Development; 59(3):336-346.

Date published: May 31, 2001
Featured in this article: Cheryl Rosenfeld, Michael Roberts.

Go to article...