The Weisman lab studies the relationship between inflammatory disease and “nucleotide receptors,” which are present on the surface of most cells. Nucleotide receptors control a range of functions including platelet aggregation, muscle contraction, neurotransmission, insulin secretion, wound healing, and cell growth. The lab has several ongoing investigations. In one project, researchers study the mechanism by which one specific nucleotide receptor subtype can prevent plaque formation and nerve degeneration associated with Alzheimer’s disease. Another project is determining the role of a different nucleotide receptor subtype in the development of Sjögren’s syndrome, a disease of the salivary gland that causes loss of saliva secretion. The lab is exploring new methods to regenerate salivary glands from single cells in animal models of Sjögren’s syndrome. Researchers are also looking at the relationship between a nucleotide receptor subtype and changes in blood vessel function that are associated with the early stages of atherosclerosis and diabetes.