People
D Cornelison
Professor, Biological Sciences
Phone: 573-882-9690
cornelisond@missouri.edu
340f Bond Life Sciences Center
D Cornelison is a professor in biological sciences. Work in Cornelison’s lab is aimed at understanding satellite cells, the stem cells responsible for growth, repair, and regeneration of skeletal muscle. In particular, the lab studies how satellite cells get information from the local environment, then use that information to decide whether to divide, move to another area in the muscle, or differentiate into functional muscle cells. This research is important not only for the insight it will provide into how the body maintains and repairs itself over a lifetime’s worth of wear and tear, but also because it may help to develop new treatments and therapies for muscle loss due to aging or degenerative diseases such as Duchenne’s muscular dystrophy.
Lab site: Cornelison Lab
News about D Cornelison
Research Topics
- Duchenne's Muscular Dystrophy
- Mouse
- Muscle
- Myofibers
- Myogenesis
- Satellite Cells
- Skeletal Muscle
- Stem Cells
- Syndecan-4
- Transdifferentiation
- Videomicroscopy
2023
Ensemble Deep Learning Object Detection Fusion for Cell Tracking, Mitosis, and Lineage. Toubal, Imad Eddine; Al-Shakarji, Noor; Cornelison, DDW; Palaniappan, K.. IEEE Open Journal of Engineering in Medicine and Biology; Pages 1-17.
Date published: August 1, 2023Featured in this article: D Cornelison.
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Normal muscle fiber type distribution is recapitulated in aged ephrin-A3-/- mice that previously lacked most slow myofibers. Arpke R W, Moritz T C, Hahn K L, Stark D A, Villalon E, Lorosn C L, Cornelison D. American journal of physiology. Cell physiology; Volume 324, Issue 3, Pages C718 - C727.
Date published: March 1, 2023Featured in this article: Robert Arpke, Christian Lorson, D Cornelison.
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2022
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche. Schuler S C, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D D W, Bentzinger F C. Frontiers in Cell and Developmental Biology; Volume 10.
Date published: November 29, 2022Featured in this article: D Cornelison.
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EphA1 receptor tyrosine kinase is localized to the nucleus in rhabdomyosarcoma from multiple species. LaCombe R, Cecchini A, Seibert M, Cornelison DDW. Biology open; Volume 11, Issue 10.
Date published: October 15, 2022Featured in this article: , D Cornelison.
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Skeletal Muscle Injury is Sufficient for Angiogenesis but Myofiber Regeneration is Required for Restoring Microvascular Integrity. Jacobsen, Nicole L; Cornelison D.D.W. ;Segal, Steven S.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology; Volume 36.
Date published: May 1, 2022Featured in this article: D Cornelison.
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Which Comes First: Angiogenesis or Myogenesis Following Punch Biopsy Injury?. Morton, Aaron B; Jacobsen, Nicole L; Cornelison D. FASEB journal : official publication of the Federation of American Societies for Experimental Biology; Volume 36.
Date published: May 1, 2022Featured in this article: D Cornelison.
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Eph/Ephrin-Based Protein Complexes: The Importance of cis Interactions in Guiding Cellular Processes. Cecchini A. , Cornelison D.D.W.. Frontiers in Molecular Biosciences; Volume 8.
Date published: January 13, 2022Featured in this article: D Cornelison.
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Myofibre injury induces capillary disruption and regeneration of disorganized microvascular networks. Jacobsen N.L. , Norton C.E. ,Shaw R.L. ,Cornelison D.D.W. ,Segal S.S.. Journal of Physiology; Volume 600, Issue 1, Pages 41 - 601.
Date published: January 1, 2022Featured in this article: D Cornelison.
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2021
Myofibre injury induces capillary disruption and regeneration of disorganized microvascular networks. Nicole L. Jacobsen, Charles E. Norton, Rebecca L. Shaw, D. D. W. Cornelison, Steven S. Segal. The Journal of Physiology; Volume 600, Issue 1, p. 41-60.
Date published: November 11, 2021Featured in this article: D Cornelison.
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2020
Epha7 promotes myogenic differentiation via cell-cell contact. Arnold LL, Cecchini A, Stark DA, Ihnat J, Craigg RN, Carter A, Zino S, Cornelison DDW. eLife; 9:e53689.
Date published: April 1, 2020Featured in this article: D Cornelison.
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2019
Barium chloride injures myofibers through calcium-induced proteolysis with fragmentation of motor nerves and microvessels. Morton AB, Norton CE, Jacobsen NL, Fernando CA, Cornelison DDW, Segal SS. Skeletal Muscle; 9(1):27.
Date published: November 6, 2019Featured in this article: D Cornelison.
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Science at Sundance. Krauss RS, Shapiro MD, Koch PL, Kardon G, Cornelison DDW. Science; 363(6433):1270.
Date published: March 22, 2019Featured in this article: D Cornelison.
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Recovery of blood flow regulation in microvascular resistance networks during regeneration of mouse gluteus maximus muscle. Fernando CA, Pangan AM, Cornelison DDW, Segal SS. Journal of Physiology; 597(5):1401-1417.
Date published: March 1, 2019Featured in this article: D Cornelison.
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2018
“Known Unknowns”: Current Questions in Muscle Satellite Cell Biology. Cornelison DDW. Current Topics in Developmental Biology; 126:205-233.
Date published: January 1, 2018Featured in this article: D Cornelison.
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2017
Methods for observing and quantifying muscle satellite cell motility and invasion in vitro. Lund DK, McAnulty P, Siegel AL, Cornelison D. Methods in Molecular Biology; 1556:303-315.
Date published: March 1, 2017Featured in this article: D Cornelison.
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Muscle stem cells: A model system for adult stem cell biology. Cornelison DDW, Perdiguero E. Methods in Molecular Biology; 1556:3-19.
Date published: March 1, 2017Featured in this article: D Cornelison.
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Muscle spindle alterations precede onset of sensorimotor deficits in Charcot–Marie–Tooth type 2E. Villalón E, Jones MR, Sibigtroth C, Zino SJ, Dale JM, Landayan DS, Shen H, Cornelison DDW, Garcia ML. Genes, Brain and Behavior; 16(2):260-270.
Date published: February 1, 2017Featured in this article: D Cornelison.
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2016
An NF-κB – EphrinA5-Dependent Communication between NG2+ Interstitial Cells and Myoblasts Promotes Muscle Growth in Neonates. Gu J-M, Wang DJ, Peterson JM, Shintaku J, Liyanarachchi S, Coppola V, Frakes AE, Kaspar BK, Cornelison DD, Guttridge DC. Developmental Cell; 36(2):215-224.
Date published: January 25, 2016Featured in this article: D Cornelison.
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2015
Ephrin-A3 promotes and maintains slow muscle fiber identity during postnatal development and reinnervation. Stark DA, Coffey NJ, Pancoast HR, Arnold LL, Walker JPD, Vallée J, Robitaille R, Garcia ML, Cornelison DDW. Journal of Cell Biology; 211(5):1077-1091.
Date published: December 7, 2015Featured in this article: D Cornelison.
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Neural activation patterns underlying basolateral amygdala influence on intra-accumbens opioid-driven consummatory versus appetitive high-fat feeding behaviors in the rat. Parker KE, McCabe MP, Johns HW, Lund DK, Odu F, Sharma R, Thakkar MM, Cornelison DDW, Will MJ. Behavioral Neuroscience; 129(6):812-821.
Date published: December 1, 2015Featured in this article: D Cornelison.
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NEDD4 Regulates PAX7 Levels Promoting Activation of the Differentiation Program in Skeletal Muscle Precursors. Bustos F, De La Vega E, Cabezas F, Thompson J, Cornelison DDW, Olwin BB, Yates JR, Olguín HC. Stem Cells; 33(10):3138-3151.
Date published: October 1, 2015Featured in this article: D Cornelison.
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2014
MMP-14 is necessary but not sufficient for invasion of three-dimensional collagen by human muscle satellite cells. Lund DK, Mouly V, Cornelison DDW. American Journal of Physiology - Cell Physiology; 307(2):C140-C149.
Date published: July 15, 2014Featured in this article: D Cornelison.
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Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength. Bentzinger CF, von Maltzahn J, Dumont NA, Stark DA, Wang YX, Nhan K, Frenette J, Cornelison DDW, Rudnicki MA. Journal of Cell Biology; 205(1):97-111.
Date published: April 1, 2014Featured in this article: D Cornelison.
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Rhabdomyosarcoma: Current challenges and their implications for developing therapies. Hettmer S, Li Z, Billin AN, Barr FG, Cornelison D, Ehrlich AR, Guttridge DC, Hayes-Jordan A, Helman LJ, Houghton PJ, Khan J, Langenau DM, Linardic CM, Pal R, Partridge TA, Pavlath GK, Rota R, Schafer BW, Shipley J, Stillman B, Wexler LH, Wagers AJ, Keller C. Cold Spring Harbor Perspectives in Medicine; 4(11):1-8.
Date published: January 1, 2014Featured in this article: D Cornelison.
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2013
Enter the matrix: Shape, signal and superhighway. Lund DK, Cornelison DDW. FEBS Journal; 280(17):4089-4099.
Date published: September 1, 2013Featured in this article: D Cornelison.
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2012
A role for RNA post-transcriptional regulation in satellite cell activation. Farina NH, Hausburg M, Betta ND, Pulliam C, Srivastava D, Cornelison DDW, Olwin BB. Skeletal Muscle; 2(1):21.
Date published: October 9, 2012Featured in this article: D Cornelison.
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Semi-automated tracking of muscle satellite cells in brightfield microscopy video. Chowdhury AS, Paul A, Bunyak F, Cornelison DDW, Palaniappan K. 2012 19th IEEE International Conference on Image Processing; 2012:2825-2828.
Date published: September 30, 2012Featured in this article: D Cornelison.
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2011
Eph/ephrin interactions modulate muscle satellite cell motility and patterning. Stark DA, Karvas RM, Siege AL, Cornelison DDW. Development; 138(24):5279-5289.
Date published: December 15, 2011Featured in this article: D Cornelison.
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CD34 promotes satellite cell motility and entry into proliferation to facilitate efficient skeletal muscle regeneration. Alfaro LAS, Dick SA, Siegel AL, Anonuevo AS, McNagny KM, Megeney LA, Cornelison DDW, Rossi FMV. Stem Cells; 29(12):2030-2041.
Date published: December 1, 2011Featured in this article: D Cornelison.
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Muscle satellite cells from GRMD dystrophic dogs are not phenotypically distinguishable from wild type satellite cells in ex vivo culture. Berg Z, Beffa LR, Cook DP, Cornelison DDW. Neuromuscular Disorders; 21(4):282-290.
Date published: April 1, 2011Featured in this article: D Cornelison.
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Muscle satellite cell proliferation and association: new insights from myofiber time-lapse imaging. Siegel AL, Kuhlmann PK, Cornelison DDW. Skeletal Muscle; 1(1):7.
Date published: February 2, 2011Featured in this article: D Cornelison.
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2010
Syndecan-3 and Notch cooperate in regulating adult myogenesis. Pisconti A, Cornelison DDW, Olguín HC, Antwine TL, Olwin BB. Journal of Cell Biology; 190(3):427-441.
Date published: August 9, 2010Featured in this article: D Cornelison.
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2009
3D timelapse analysis of muscle satellite cell motility. Siegel A, Atchison K, Fisher KE, Davis GE, Cornelison DDW. Stem Cells; 27(10):2527-2538.
Date published: October 1, 2009Featured in this article: D Cornelison.
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Syndecan-4-Expressing Muscle Progenitor Cells in the SP Engraft as Satellite Cells during Muscle Regeneration. Tanaka KK, Hall JK, Troy AA, Cornelison DDW, Majka SM, Olwin BB. Cell Stem Cell; 4(3):217-225.
Date published: March 6, 2009Featured in this article: D Cornelison.
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2008
Context matters: In vivo and in vitro influences on muscle satellite cell activity. Cornelison DDW. Journal of Cellular Biochemistry; 105(3):663-669.
Date published: October 15, 2008Featured in this article: D Cornelison.
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Neural cell adhesion molecule (NCAM) marks adult myogenic cells committed to differentiation. Capkovic KL, Stevenson S, Johnson MC, Thelen JJ, Cornelison DDW. Experimental Cell Research; 314(7):1553-1564.
Date published: April 15, 2008Featured in this article: Marc Johnson, Jay Thelen, D Cornelison.
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2005
The p38α/β MAPK functions as a molecular switch to activate the quiescent satellite cell. Jones NC, Tyner KJ, Nibarger L, Stanley HM, Cornelison DDW, Fedorov YV, Olwin BB. Journal of Cell Biology; 169(1):105-116.
Date published: April 11, 2005Featured in this article: D Cornelison.
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2004
Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration. Cornelison DDW, Wilcox-Adelman SA, Goetinck PF, Rauvala H, Rapraeger AC, Olwin BB. Genes and Development; 18(18):2231-2236.
Date published: September 15, 2004Featured in this article: D Cornelison.
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2002
Chapter 5 Role of cytokines in skeletal muscle growth and differentiation. Olwin BB, Bren-Mattison Y, Cornelison DDW, Fedorov YV, Flanagan-Steet H, Jones NC. Advances in Developmental Biology and Biochemistry; 11(C):97-126.
Date published: January 1, 2002Featured in this article: D Cornelison.
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2001
Syndecan-3 and syndecan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regeneration. Cornelison DDW, Filla MS, Stanley HM, Rapraeger AC, Olwin BB. Developmental Biology; 239(1):79-94.
Date published: November 1, 2001Featured in this article: D Cornelison.
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2000
MyoD(-/-) satellite cells in single-fiber culture are differentiation defective and MRF4 deficient. Cornelison DDW, Olwin BB, Rudnicki MA, Wold BJ. Developmental Biology; 224(2):122-137.
Date published: August 15, 2000Featured in this article: D Cornelison.
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1997
Single-cell analysis of regulatory gene expression in quiescent and activated mouse skeletal muscle satellite cells. Cornelison DDW, Wold BJ. Developmental Biology; 191(2):270-283.
Date published: November 15, 1997Featured in this article: D Cornelison.
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