People
Kamlendra Singh
Assistant Professor, Veterinary Pathobiology, & Director, Molecular Interactions Core
Phone: 573-882-9024
ksingh@missouri.edu
440E Bond Life Sciences Center
News about Kamlendra Singh
Mar 16, 2022
Competing with COVID: Researcher suggests varying from vaccines to fight virus
Feb 02, 2022
Outlining Omicron: researchers determine key mutations in the latest COVID-19 variant
2023
Synthesis and preclinical evaluation of a novel fluorine-18 labeled small-molecule PET radiotracer for imaging of CXCR3 receptor in mouse models of atherosclerosis. Alluri, Santosh R. ; Higashi, Yusuke ; Berendzen, Ashley ; Grisanti, Laurel A. ; Watkinson, Lisa D. ; Singh, Kamlendra ; Hoffman, Timothy J. ; Carmack, Terry ; Devanny, Elizabeth A.. EJNMMI Research; Volume 13, Issue 1.
Date published: August 1, 2023Featured in this article: Kamlendra Singh.
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ABT1 modifies SMARD1 pathology via interactions with IGHMBP2 and stimulation of ATPase and helicase activity. Vadla G P, Ricardez Hernandez S M, Mao J, Garro-Kacher M O, Lorson Z C, Rice R P, Hansen S A, Lorson C L, Singh K, Lorson M A. JCI Insight; Volume 8, Issue 2.
Date published: January 24, 2023Featured in this article: , , , Christian Lorson, Monique Lorson, Kamlendra Singh.
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2022
Small molecule inhibition of mitochondrial LonP1 protease by allosteric blockade of ATP -binding and -hydrolysis. J. Lee, A. K. Pandey, S. Venkatesh, J. Thilagavathi, T. Honda, K. Singh and C. K. Suzuki. J. Biol Chem; 298: 101719.
Date published: October 19, 2022Featured in this article: Kamlendra Singh.
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Omicron SARS-CoV-2 variant: Unique features and their impact on pre-existing antibodies. S. R. Kannan, A. N. Spratt, K. Sharma, H. S. Chand, S. N. Byrareddy and K. Singh . Autoimmun; 126, 102779.
Date published: October 19, 2022Featured in this article: Kamlendra Singh.
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Molecular dynamic study of SARS-CoV-2 with various S protein mutations and their effect on thermodynamic properties. M. Abdalla, W. Ali Eltayb, A. A. El-Arabey, K. Singh and X. Jiang (2021). . Comput. Biol. Med; 141:105025..
Date published: October 19, 2022Featured in this article: Kamlendra Singh.
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Continued Complexity of Mutations in Omicron Sublineages. Spratt A N, Kannan S R, Sharma K, Sachdev S, Kandasamy S L, Sonnerborg A, Lorson C L, Singh K. Biomedicines 2022; 10, 2593..
Date published: October 16, 2022Featured in this article: Shrikesh (Rick) Sachdev, Shree Lekha Kandasamy, Christian Lorson, Kamlendra Singh.
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Mutations in the monkeypox virus replication complex: Potential contributing factors to the 2022 outbreak. Kannan S R, Sachdev S, Reddy A S, Kandasamy S L, Byrareddy S N, Lorson C L, Singh K. Autoimmunity 2022; Volume 133.
Date published: October 14, 2022Featured in this article: Shrikesh (Rick) Sachdev, Shree Lekha Kandasamy, Christian Lorson, Kamlendra Singh.
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Complex Mutation Pattern of Omicron BA.2: Evading Antibodies without Losing Receptor Interactions. Kannan S R, Spratt A N, Sharma K, Goyal R, Sonnerborg A, Apparsundaram S, Lorson C L, Byrareddy S, Singh K. International Journal of Molecular Sciences; .
Date published: May 16, 2022Featured in this article: , Christian Lorson, Kamlendra Singh.
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Novel Naturally Occurring Dipeptides and Single-Stranded Oligonucleotide Act as Entry Inhibitors and Exhibit a Strong Synergistic Anti-HIV-1 Profile. Ceña-Diez R, Singh K, Spetz A & Sönnerborg A. Infectious Diseases and Therapy; .
Date published: April 7, 2022Featured in this article: Kamlendra Singh.
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Deletion of Specific Conserved Motifs from the N-Terminal Domain of αB-Crystallin Results in the Activation of Chaperone Functions. Mahalingam S, Shankar G, Mooney B P, Singh K, Santhoshkumar P, Sharma K K. International Journal of Molecular Sciences; .
Date published: January 20, 2022Featured in this article: Brian Mooney, Kamlendra Singh.
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Trans cohort metabolic reprogramming towards glutaminolysis in long-term successfully treated HIV-infection. Mikaeloff F, Svensson A S, Ikomey G M, Kirshnan S, Sperk M, Gupta S, Magdaleno, G D V, Escos A, Lyonga E, Okomo M C, Tagne C T, Babu H, Lorson C L, Vegvari A, Banerjea A C, Kele J, Hanna L E, Singh K, de Magalhaes J P, Benfeitas R, Neogi U. Communications Biology; Volume 5, Issue 1.
Date published: January 11, 2022Featured in this article: Christian Lorson, Kamlendra Singh.
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2021
Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 viruses. Kannan SR, Spratt AN, Cohen AR, Naqvi SH, Chand HS, Quinn TP, Lorson CL, Byrareddy SN, Singh K. Journal of Autoimmunity; 124:102715.
Date published: November 1, 2021Featured in this article: Christian Lorson, Kamlendra Singh.
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Discovery and Evaluation of Entry Inhibitors for SARS-CoV-2 and Its Emerging Variants. Acharya A., Pandey K., Thurman M.,Klug E., Trivedi J.,Sharma K., Lorson C.L., Singh K., Byrareddy S.N.. Journal of Virology; Volume 95, Issue 24.
Date published: November 1, 2021Featured in this article: Christian Lorson, Kamlendra Singh.
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Fecal metabolome signature in the HIV-1 elite control phenotype: Enrichment of dipeptides acts as an HIV-1 antagonist but a Prevotella agonist. Sperk M, Ambikan AT, Ray S, Singh K, Mikaeloff F, Diez RC, Narayanan A, Vesterbacka J, Nowak P, Sönnerborg A, Neogi U. Journal of Virology; 95(18):e00479-21.
Date published: September 1, 2021Featured in this article: Kamlendra Singh.
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Therapeutic implications of SARS-CoV-2 dysregulation of the gut-brain-lung axis. Johnson SD, Olwenyi OA, Bhyravbhatla N, Thurman M, Pandey K, Klug EA, Johnston M, Dyavar SR, Acharya A, Podany AT, Fletcher CV, Mohan M, Singh K, Byrareddy SN. World Journal of Gastroenterology; 27(29):4763-4783.
Date published: August 7, 2021Featured in this article: Kamlendra Singh.
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Copper metabolism as a unique vulnerability in cancer. Shanbhag VC, Gudekar N, Jasmer K, Papageorgiou C, Singh K, Petris MJ. Biochimica et Biophysica Acta - Molecular Cell Research; 1868(2):118893.
Date published: February 1, 2021Featured in this article: Kamlendra Singh, Michael Petris.
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Coronavirus helicases: attractive and unique targets of antiviral drug-development and therapeutic patents. Spratt AN, Gallazzi F, Quinn TP, Lorson CL, Sönnerborg A, Singh K. Expert Opinion on Therapeutic Patents; 31(4):339-350.
Date published: January 1, 2021Featured in this article: Christian Lorson, Kamlendra Singh.
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Evolution, correlation, structural impact and dynamics of emerging SARS-CoV-2 variants. Spratt AN, Kannan SR, Woods LT, Weisman GA, Quinn TP, Lorson CL, Sönnerborg A, Byrareddy SN, Singh K. Computational and Structural Biotechnology Journal; 19:3799-3809.
Date published: January 1, 2021Featured in this article: Gary Weisman, Christian Lorson, Kamlendra Singh.
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2020
A Formative Usability Study to Improve Prescriptive Systems for Bioinformatics Big Data. Singh K, Li S, Jahnke I, Pandey A, Lyu Z, Joshi T, Calyam P. Proceedings - 2020 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2020; 735-742.
Date published: December 16, 2020Featured in this article: Kamlendra Singh, Zhen Lyu, Trupti Joshi.
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Infectivity of SARS-CoV-2: there Is Something More than D614G?. Kannan SR, Spratt AN, Quinn TP, Heng X, Lorson CL, Sönnerborg A, Byrareddy SN, Singh K. Journal of Neuroimmune Pharmacology; 15(4):574-577.
Date published: December 1, 2020Featured in this article: Christian Lorson, Kamlendra Singh.
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Increased HIV in Greater Kinshasa Urban Health Zones: Democratic Republic of Congo (2017–2018). Pour M, James L, Singh K, Mampunza S, Baer F, Scott JA, Berg MG, Rodgers MA, Cloherty GA, Hackett J Jr, McArthur CP. AIDS Research and Therapy; 17(1):67.
Date published: December 1, 2020Featured in this article: Kamlendra Singh.
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Utility of Proteomics in Emerging and Re-Emerging Infectious Diseases Caused by RNA Viruses. Sperk M, Van Domselaar R, Rodriguez JE, Mikaeloff F, Sá Vinhas B, Saccon E, Sönnerborg A, Singh K, Gupta S, Végvári Á, Neogi U. Journal of Proteome Research; 19(11):4259-4274.
Date published: November 6, 2020Featured in this article: Kamlendra Singh.
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2′-fluoro-modified pyrimidines enhance affinity of RNA oligonucleotides to HIV-1 reverse transcriptase. Gruenke, PR, Alam, KK, Singh K, Burke DH. RNA; 26(11):1667-1679.
Date published: November 1, 2020Featured in this article: Kamlendra Singh, Donald Burke-Agüero.
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Feasibility of known rna polymerase inhibitors as anti-sars-cov-2 drugs. Neogi U, Hill KJ, Ambikan AT, Heng X, Quinn TP, Byrareddy SN, Sönnerborg A, Sarafianos SG, Singh K. Pathogens; 9(5):320.
Date published: May 1, 2020Featured in this article: Kamlendra Singh.
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Drug Resistance Mutations Against Protease, Reverse Transcriptase and Integrase Inhibitors in People Living With HIV-1 Receiving Boosted Protease Inhibitors in South Africa. Obasa AE, Mikasi SG, Brado D, Cloete R, Singh K, Neogi U, Jacobs GB. Frontiers in Microbiology; 11:438.
Date published: March 20, 2020Featured in this article: Kamlendra Singh.
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Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells. Appelberg S, Gupta S, Akusjärvi SS, Ambikan AT, Mikaeloff F, Saccon E, Végvári Á, Benfeitas R, Sperk M, Ståhlberg M, Krishnan S, Singh K, Penninger JM, Mirazimi A, Neogi U. Emerging Microbes and Infections; 1748-1760.
Date published: January 1, 2020Featured in this article: Kamlendra Singh.
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2019
12-Hydroxy-Jasmonoyl-l-Isoleucine Is an Active Jasmonate That Signals through CORONATINE INSENSITIVE 1 and Contributes to the Wound Response in Arabidopsis. Poudel AN, Holtsclaw RE, Kimberlin A, Sen S, Zeng S, Joshi T, Lei Z, Sumner LW, Singh K, Matsuura H, Koo AJ. Plant and Cell Physiology; 60(10):2152-2166.
Date published: October 1, 2019Featured in this article: Trupti Joshi, Lloyd Sumner, Kamlendra Singh.
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Virion-associated, host-derived DHX9/RNA helicase A enhances the processivity of HIV-1 reverse transcriptase on genomic RNA. Brady S, Singh G, Bolinger C, Song Z, Boeras I, Weng K, Trent B, Brown WC, Singh K, Boris-Lawrie K, Heng X. Journal of Biological Chemistry; 294(30):11473-11485.
Date published: July 26, 2019Featured in this article: Kamlendra Singh.
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GS-CA compounds: First-in-class HIV-1 capsid inhibitors covering multiple grounds. Singh K, Gallazzi F, Hill KJ, Burke DH, Lange MJ, Quinn TP, Neogi U, Sönnerborg A. Frontiers in Microbiology; 10(JUN):1227.
Date published: June 20, 2019Featured in this article: Kamlendra Singh, Donald Burke-Agüero.
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Long-acting Anti-HIV drugs targeting HIV-1 reverse transcriptase and integrase. Singh K, Sarafianos SG, Sönnerborg A. Pharmaceuticals; 12(2):62.
Date published: June 1, 2019Featured in this article: Kamlendra Singh.
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Novel Hepatitis B Virus Capsid-Targeting Antiviral That Aggregates Core Particles and Inhibits Nuclear Entry of Viral Cores. Huber AD, Pineda DL, Liu D, Boschert KN, Gres AT, Wolf JJ, Coonrod MN, Tang J, Laughlin TG, Yang Q, Puray-Chavez MN, Ji J, Singh K, Kirby KA, Wang Z, Sarafianos SG. ACS Infectious Diseases; 5(5):750-758.
Date published: May 10, 2019Featured in this article: Kamlendra Singh.
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HIV-1 subtype C with PYxE insertion has enhanced binding of Gag-p6 to host cell protein ALIX and increased replication fitness. van Domselaar R, Njenda DT, Rao R, Sönnerborg A, Singh K, Neogi U. Journal of Virology; 93(9):e00077-19.
Date published: May 1, 2019Featured in this article: Kamlendra Singh.
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ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis. Shanbhag V, Jasmer-McDonald K, Zhu S, Martin AL, Gudekar N, Khan A, Ladomersky E, Singh K, Weisman GA, Petris MJ. Proceedings of the National Academy of Sciences of the United States of America; 116(14):6836-6841.
Date published: April 2, 2019Featured in this article: Kamlendra Singh, Gary Weisman, Michael Petris.
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CMCDG, a novel nucleoside analog with favorable safety features, exerts potent activity against wild-type and entecavir-resistant hepatitis B virus. Higashi-Kuwata N, Hayashi S, Das D, Kohgo S, Murakami S, Hattori S-I, Imoto S, Venzon DJ, Singh K, Sarafianos SG, Tanaka Y, Mitsuya H. Antimicrobial Agents and Chemotherapy; 63(4):e02143-18.
Date published: April 1, 2019Featured in this article: Kamlendra Singh.
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Strain-specific effect on biphasic DNA binding by HIV-1 integrase. Hill KJ, Rogers LC, Njenda DT, Burke DH, Sarafianos SG, Sonnerborg A, Neogi U, Singh K. AIDS; 33(3):588-592.
Date published: March 1, 2019Featured in this article: Donald Burke-Agüero, Kamlendra Singh.
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Bi-Allelic mutations of LONP1 encoding the mitochondrial LonP1 protease cause pyruvate dehydrogenase deficiency and profound neurodegeneration with progressive cerebellar atrophy. Nimmo GAM, Venkatesh S, Pandey AK, Marshall CR, Hazrati L-N, Blaser S, Ahmed S, Cameron J, Singh K, Ray PN, Suzuki CK, Yoon G. Human Molecular Genetics; 28(2):290-306.
Date published: January 15, 2019Featured in this article: Kamlendra Singh.
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2018
Analyses of HIV-1 integrase sequences prior to South African national HIV-Treatment program and available of integrase inhibitors in Cape Town, South Africa. Brado D, Obasa AE, Ikomey GM, Cloete R, Singh K, Engelbrecht S, Neogi U, Jacobs GB. Scientific Reports; 8(1):4709.
Date published: December 1, 2018Featured in this article: Kamlendra Singh.
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Contribution of a multifunctional polymerase region of footand-mouth disease virus to lethal mutagenesis. De La Higuera I, Ferrer-Octa C, Moreno E, De Ávila AI, Soria ME, Singh K, Caridi F, Sobrino F, Sarafianos SG, Perales C, Verdaguer N, Domingo E. Journal of Virology; 92(20):e01119.
Date published: October 1, 2018Featured in this article: Kamlendra Singh.
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Antiretroviral potency of 4⁰-ethnyl-2⁰-fluoro-2⁰-deoxyadenosine, tenofovir alafenamide and second-generation NNRTIs across diverse HIV-1 subtypes. Njenda DT, Aralaguppe SG, Singh K, Rao R, Sönnerborg A, Sarafianos SG, Neogi U. Journal of Antimicrobial Chemotherapy; 73(10):2721-2728.
Date published: October 1, 2018Featured in this article: Kamlendra Singh.
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Structural implications of genotypic variations in HIV-1 integrase from diverse subtypes. Rogers L, Obasa AE, Jacobs GB, Sarafianos SG, Sönnerborg A, Neogi U, Singh K. Frontiers in Microbiology; 9(AUG):1754.
Date published: August 2, 2018Featured in this article: Kamlendra Singh.
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Acetylation and phosphorylation of human TFAM regulate TFAM-DNA interactions via contrasting mechanisms. King GA, Hashemi Shabestari M, Taris KK-H, Pandey AK, Venkatesh S, Thilagavathi J, Singh K, Krishna Koppisetti R, Temiakov D, Roos WH, Suzuki CK, Wuite GJL. Nucleic Acids Research; 46(7):3633-3642.
Date published: April 20, 2018Featured in this article: Kamlendra Singh.
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Erratum: Author Correction: Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and availability of integrase inhibitors in Cape Town, South Africa (Scientific reports (2018) 8 1 (4709)). Brado D, Obasa AE, Ikomey GM, Cloete R, Singh K, Engelbrecht S, Neogi U, Jacobs GB. Scientific Reports; 8(1):6262.
Date published: April 16, 2018Featured in this article: Kamlendra Singh.
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Family A and B DNA polymerases in cancer: Opportunities for therapeutic interventions. Shanbhag V, Sachdev S, Flores JA, Modak MJ, Singh K. Biology; 7(1):5.
Date published: March 1, 2018Featured in this article: Kamlendra Singh.
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Ex-vivo antiretroviral potency of newer integrase strand transfer inhibitors cabotegravir and bictegravir in HIV type 1 non-B subtypes. Neogi U, Singh K, Aralaguppe SG, Rogers LC, Njenda DT, Sarafianos SG, Hejdeman B, Sönnerborg A. AIDS; 32(4):469-476.
Date published: February 20, 2018Featured in this article: Kamlendra Singh.
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2017
3-hydroxypyrimidine-2,4-diones as novel hepatitis b virus antivirals targeting the viral ribonuclease H. Huber AD, Michailidis E, Tang J, Puray-Chavez MN, Boftsi M, Wolf JJ, Boschert KN, Sheridan MA, Leslie MD, Kirby KA, Singh K, Mitsuya H, Parniak MA, Wang Z, Sarafianos SG. Antimicrobial Agents and Chemotherapy; 61(6):e00245-17.
Date published: June 1, 2017Featured in this article: Kamlendra Singh.
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Molecular and functional bases of selection against a mutation bias in an RNA virus. De La Higuera I, Ferrer-Octa C, De Ávila AI, Perales C, Sierra M, Singh K, Sarafianos SG, Dehouck Y, Bastolla U, Verdaguer N, Domingo E. Genome Biology and Evolution; 9(5):1212-1228.
Date published: May 1, 2017Featured in this article: Kamlendra Singh.
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Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity. Kimani SG, Kumar S, Bansal N, Singh K, Kholodovych V, Comollo T, Peng Y, Kotenko SV, Sarafianos SG, Bertino JR, Welsh WJ, Birge RB. Scientific Reports; 7:43908.
Date published: March 8, 2017Featured in this article: Kamlendra Singh.
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Physiological Mg2+ conditions significantly alter the inhibition of HIV-1 and HIV-2 Reverse transcriptases by nucleoside and non-nucleoside inhibitors in vitro. Achuthan V, Singh K, Destefano JJ. Biochemistry; 56(1):33-46.
Date published: January 10, 2017Featured in this article: Kamlendra Singh.
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Increased replication capacity following evolution of PYxE insertion in Gag-p6 is associated with enhanced virulence in HIV-1 subtype C from East Africa. Aralaguppe SG, Winner D, Singh K, Sarafianos SG, Quiñones-Mateu ME, Sönnerborg A, Neogi U. Journal of Medical Virology; 89(1):106-111.
Date published: January 1, 2017Featured in this article: Kamlendra Singh.
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A 2-hydroxyisoquinoline-1,3-dione active-site RNase H inhibitor binds in multiple modes to HIV-1 reverse transcriptase. Kirby KA, Myshakina NA, Christen MT, Chen Y-L, Schmidt HA, Huber AD, Xi Z, Kim S, Rao RK, Kramer ST, Yang Q, Singh K, Parniak MA, Wang Z, Ishima R, Sarafianos SG. Antimicrobial Agents and Chemotherapy; 61(10).
Date published: January 1, 2017Featured in this article: Kamlendra Singh.
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2016
Structural basis of HIV inhibition by translocationdefective RT inhibitor 4′-ethynyl-2-fluoro-2′- deoxyadenosine (EFdA). Salie ZL, Kirby KA, Michailidis E, Marchand B, Singh K, Rohan LC, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG. Proceedings of the National Academy of Sciences of the United States of America; 113(33):9274-9279.
Date published: August 16, 2016Featured in this article: Kamlendra Singh.
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Virological failure in patients with HIV-1 subtype C receiving antiretroviral therapy: an analysis of a prospective national cohort in Sweden. Häggblom A, Svedhem V, Singh K, Sönnerborg A, Neogi U. The Lancet HIV; 3(4):e166-e174.
Date published: April 1, 2016Featured in this article: Kamlendra Singh.
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Factors influencing the efficacy of rilpivirine in HIV-1 subtype C in low- and middle-income countries. Neogi U, Häggblom A, Singh K, Rogers LC, Rao SD, Amogne W, Schülter E, Zazzi M, Arnold E, Sarafianos SG, Sönnerborg A. Journal of Antimicrobial Chemotherapy; 71(2):367-371.
Date published: February 1, 2016Featured in this article: Kamlendra Singh.
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2015
4′-modified nucleoside analogs: Potent inhibitors active against entecavir-resistant hepatitis B virus. Takamatsu Y, Tanaka Y, Kohgo S, Murakami S, Singh K, Das D, Venzon DJ, Amano M, Higashi-Kuwata N, Aoki M, Delino NS, Hayashi S, Takahashi S, Sukenaga Y, Haraguchi K, Sarafianos SG, Maeda K, Mitsuya H. Hepatology; 62(4):1024-1036.
Date published: October 1, 2015Featured in this article: Kamlendra Singh.
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CODAS syndrome is associated with mutations of LONP1, encoding mitochondrial AAA+ lon protease. Strauss KA, Jinks RN, Puffenberger EG, Venkatesh S, Singh K, Cheng I, Mikita N, Thilagavathi J, Lee J, Sarafianos S, Benkert A, Koehler A. American Journal of Human Genetics; 96(1):121-135.
Date published: January 8, 2015Featured in this article: Kamlendra Singh.
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Multifunctionality of a picornavirus polymerase domain: Nuclear localization signal and nucleotide recognition. Ferrer-Octa C, De La Higuera I, Caridi F, Sánchez-Aparicio MT, Moreno E, Perales C, Singh K, Sarafianos SG, Sobrino F, Domingo E, Verdaguer N. Journal of Virology; 89(13):6848-6859.
Date published: January 1, 2015Featured in this article: Kamlendra Singh.
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Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247. Kirby KA, Ong YT, Hachiya A, Laughlin TG, Chiang LA, Pan Y, Moran JL, Marchand B, Singh K, Gallazzi F, Quinn TP, Yoshimura K, Murakami T, Matsushita S, Sarafianos SG. FASEB Journal; 29(1):70-80.
Date published: January 1, 2015Featured in this article: Kamlendra Singh.
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2014
Drug resistance in non-B subtype HIV-1: Impact of HIV-1 reverse transcriptase inhibitors. Singh K, Flores JA, Kirby KA, Neogi U, Sonnerborg A, Hachiya A, Das K, Arnold E, McArthur C, Parniak M, Sarafianos SG. Viruses; 6(9):3535-3562.
Date published: September 24, 2014Featured in this article: Kamlendra Singh.
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Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses. Adedeji AO, Singh K, Kassim A, Coleman CM, Elliott R, Weiss SR, Frieman MB, Sarafianos SG. Antimicrobial Agents and Chemotherapy; 58(8):4894-4898.
Date published: August 1, 2014Featured in this article: Kamlendra Singh.
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4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms. Michailidis E, Huber AD, Ryan EM, Ong YT, Leslie MD, Matzek KB, Singh K, Marchand B, Hagedorn AN, Kirby KA, Rohan LC, Kodama EN, Mitsuya H, Parniak MA, Sarafianosa SG. Journal of Biological Chemistry; 289(35):24533-24548.
Date published: January 1, 2014Featured in this article: Kamlendra Singh.
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2013
Effects of substitutions at the 4′ and 2 positions on the bioactivity of 4′-ethynyl-2-fluoro-2′-deoxyadenosine. Kirby KA, Michailidis E, Fetterly TL, Steinbach MA, Singh K, Marchand B, Leslie MD, Hagedorn AN, Kodama EN, Marquez VE, Hughes SH, Mitsuya H, Parniak MA, Sarafianos SG. Antimicrobial Agents and Chemotherapy; 57(12):6254-6264.
Date published: December 1, 2013Featured in this article: Kamlendra Singh.
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Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms. Adedeji AO, Severson W, Jonsson C, Singh K, Weiss SR, Sarafianosa SG. Journal of Virology; 87(14):8017-8028.
Date published: July 1, 2013Featured in this article: Kamlendra Singh.
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Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA. Michailidis E, Ryan EM, Hachiya A, Kirby KA, Marchand B, Leslie MD, Huber AD, Ong YT, Jackson JC, Singh K, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG. Retrovirology; 10(1):65.
Date published: June 24, 2013Featured in this article: Kamlendra Singh.
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Repeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of foot-and-mouth disease virus in host cells. Rai DK, Schafer EA, Singh K, McIntosh MA, Sarafianos SG, Rieder E. Antiviral Research; 98(3):380-385.
Date published: June 1, 2013Featured in this article: Kamlendra Singh.
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Affinity labeling of hepatitis C virus replicase with a nucleotide analogue: Identification of binding site. Manvar D, Singh K, Pandey VN. Biochemistry; 52(2):432-444.
Date published: January 15, 2013Featured in this article: Kamlendra Singh.
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2012
Biochemical mechanism of HIV-1 resistance to rilpivirine. Singh K, Marchand B, Rai DK, Sharma B, Michailidis E, Ryan EM, Matzek KB, Leslie MD, Hagedorn AN, Li Z, Norden PR, Hachiya A, Parniak MA, Xu H-T, Wainberg MA, Sarafianos SG. Journal of Biological Chemistry; 287(45):38110-38123.
Date published: November 2, 2012Featured in this article: Kamlendra Singh.
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Severe acute respiratory syndrome coronavirus replication inhibitor that interferes with the nucleic acid unwinding of the viral helicase. Adedeji AO, Singh K, Calcaterra NE, DeDiego ML, Enjuanes L, Weiss S, Sarafianos SG. Antimicrobial Agents and Chemotherapy; 56(9):4718-4728.
Date published: September 1, 2012Featured in this article: Kamlendra Singh.
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HIV-1 reverse transcriptase (RT) polymorphism 172K suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and non-nucleoside RT inhibitors. Hachiya A, Marchand B, Kirby KA, Michailidis E, Tu X, Palczewski K, Ong YT, Li Z, Griffin DT, Schuckmann MM, Tanuma J, Oka S, Singh K, Kodama EN, Sarafianos SG. Journal of Biological Chemistry; 287(35):29988-29999.
Date published: August 24, 2012Featured in this article: Kamlendra Singh.
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Structural and inhibition studies of the RNase H function of xenotropic murine leukemia virus-related virus reverse transcriptase. Kirby KA, Marchand B, Ong YT, Ndongwe TP, Hachiya A, Michailidis E, Leslie MD, Sietsema DV, Fetterly TL, Dorst CA, Singh K, Wang Z, Parniak MA, Sarafianos SG. Antimicrobial Agents and Chemotherapy; 56(4):2048-2061.
Date published: April 1, 2012Featured in this article: Kamlendra Singh.
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Mechanism of interaction of human mitochondrial DNA polymerase γ with the novel nucleoside reverse transcriptase inhibitor 4′-ethynyl-2-fluoro- 2′-deoxyadenosine indicates a low potential for host toxicity. Sohl CD, Singh K, Kasiviswanathan R, Copeland WC, Mitsuya H, Sarafianos SG, Anderson KS. Antimicrobial Agents and Chemotherapy; 56(3):1630-1634.
Date published: March 1, 2012Featured in this article: Kamlendra Singh.
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Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase. Ndongwe TP, Adedeji AO, Michailidis E, Ong YT, Hachiya A, Marchand B, Ryan EM, Rai DK, Kirby KA, Whatley AS, Burke DH, Johnson M, Ding S, Zheng Y-M, Liu S-L, Kodama E-I, Delviks-Frankenberry KA, Pathak VK, Mitsuya H, Parniak MA, Singh K, Sarafianos SG. Nucleic Acids Research; 40(1):345-359.
Date published: January 1, 2012Featured in this article: Donald Burke-Agüero, Marc Johnson, Kamlendra Singh.
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Multitasking in the mitochondrion by the ATP-dependent Lon protease. Venkatesh S, Lee J, Singh K, Lee I, Suzuki CK. Biochimica et Biophysica Acta - Molecular Cell Research; 1823(1):56-66.
Date published: January 1, 2012Featured in this article: Kamlendra Singh.
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Mechanism of nucleic acid unwinding by SARS-CoV helicase. Adedeji AO, Marchand B, Te Velthuis AJ, Snijder EJ, Weiss S, Eoff RL, Singh K, Sarafianos SG. PLoS ONE; 7(5):e36521.
Date published: January 1, 2012Featured in this article: Kamlendra Singh.
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Characterization of catalytic carboxylate triad in non-replicative DNA polymerase III (pol E) of Geobacillus kaustophilus HTA. Sandalli C, Singh K, Modak MJ. Cellular and Molecular Biology; 58(1):44-49.
Date published: January 1, 2012Featured in this article: Kamlendra Singh.
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Inhibition of P. Falciparum PfATP6 by curcumin and its derivatives: A bioinformatic study. Shukla A, Singh A, Pathak LP, Shrivastava N, Tripathi PK, Singh MP, Singh K. Cellular and Molecular Biology; 58(1):182-186.
Date published: January 1, 2012Featured in this article: Kamlendra Singh.
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Preparation of biologically active single-chain variable antibody fragments that target the HIV-1 GP120 V3 loop. Ong YT, Kirby KA, Hachiya A, Chiang LA, Marchand B, Yoshimura K, Murakami T, Singh K, Matsushita S, Sarafianos SG. Cellular and Molecular Biology; 58(1):71-79.
Date published: January 1, 2012Featured in this article: Kamlendra Singh.
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Structural and biochemical basis for the difference in the helicase activity of two different constructs of sars-cov helicase. Adedeji AO, Singh K, Sarafianos SG. Cellular and Molecular Biology; 58(1):115-121.
Date published: January 1, 2012Featured in this article: Kamlendra Singh.
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Effect of translocation defective reverse transcriptase inhibitors on the activity of n348i, A connection subdomain drug resistant HIV-1 reverse transcriptase mutant. Michailidis E, Singh K, Ryan EM, Hachiya A, Ong YT, Kirby KA, Marchand B, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG. Cellular and Molecular Biology; 58(1):187-195.
Date published: January 1, 2012Featured in this article: Kamlendra Singh.
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2011
K70Q adds high-level tenofovir resistance to “Q151M complex” HIV reverse transcriptase through the enhanced discrimination mechanism. Hachiya A, Kodama EN, Schuckmann MM, Kirby KA, Michailidis E, Sakagami Y, Oka S, Singh K, Sarafianos SG. PLoS ONE; 6(1):e16242.
Date published: January 1, 2011Featured in this article: Kamlendra Singh.
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The sugar ring conformation of 4′-ethynyl-2-fluoro-2′-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase. Kirby KA, Singh K, Michailidis E, Marchand B, Kodama EN, Ashida N, Mitsuya H, Parniak MA, Sarafianos SG. Molecular and Cellular Biology; 57(1):40-46.
Date published: January 1, 2011Featured in this article: Kamlendra Singh.
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Emerging trends in biochemistry issue. Sharma B, Watal G, Singh K. Molecular and Cellular Biology; 57(1):1-2.
Date published: January 1, 2011Featured in this article: Kamlendra Singh.
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2010
The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine. Schuckmann MM, Marchand B, Hachiya A, Kodama EN, Kirby KA, Singh K, Sarafianos SG. Journal of Biological Chemistry; 285(49):38700-38709.
Date published: December 3, 2010Featured in this article: Kamlendra Singh.
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Divergent evolution in reverse transcriptase (RT) of HIV-1 group O and M lineages: Impact on structure, fitness, and sensitivity to nonnucleoside RT inhibitors. Tebit DM, Lobritz M, Lalonde M, Immonen T, Singh K, Sarafianos S, Herchenröder O, Kräusslich H-G, Arts EJ. Journal of Virology; 84(19):9817-9830.
Date published: October 1, 2010Featured in this article: Kamlendra Singh.
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Structural aspects of drug resistance and inhibition of HIV-1 reverse transcriptase. Singh K, Marchand B, Kirby KA, Michailidis E, Sarafianos SG. Viruses; 2(2):606-638.
Date published: February 1, 2010Featured in this article: Kamlendra Singh.
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Inhibitors of foot and mouth disease virus targeting a novel pocket of the RNA-dependent RNA polymerase. Durk RC, Singh K, Cornelison CA, Rai DK, Matzek KB, Leslie MD, Schafer E, Marchand B, Adedeji A, Michailidis E, Dorst CA, Moran J, Pautler C, Rodriguez LL, Mcintosh MA, Rieder E, Sarafianos SG. PLoS ONE; 5(12):e15049.
Date published: January 1, 2010Featured in this article: Kamlendra Singh.
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2009
Mechanism of inhibition of HIV-1 reverse transcriptase by 4′-ethynyl-2-fluoro-2′-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor. Michailidis E, Marchand B, Kodama EN, Singh K, Matsuoka M, Kirby KA, Ryan EM, Sawani AM, Nagy E, Ashida N, Mitsuya H, Parniak MA, Sarafianos SG. Journal of Biological Chemistry; 284(51):35681-35691.
Date published: December 18, 2009Featured in this article: Kamlendra Singh.
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A new DNA polymerase i from Geobacillus caldoxylosilyticus TK4: Cloning, characterization, and mutational analysis of two aromatic residues. Sandalli C, Singh K, Modak MJ, Ketkar A, Canakci S, Demit I, Belduz AO. Applied Microbiology and Biotechnology; 84(1):105-117.
Date published: August 1, 2009Featured in this article: Kamlendra Singh.
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2008
Identification of a new motif required for the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I (Klenow fragment): The RRRY motif is necessary for the binding of single-stranded DNA substrate and the template strand of the mismatched duplex. Kukreti P, Singh K, Ketkar A, Modak MJ. Journal of Biological Chemistry; 283(26):17979-17990.
Date published: June 27, 2008Featured in this article: Kamlendra Singh.
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2007
Participation of the fingers subdomain of Escherichia coli DNA polymerase I in the strand displacement synthesis of DNA. Singh K, Srivastava A, Patel SS, Modak MJ. Journal of Biological Chemistry; 282(14):10594-10604.
Date published: April 6, 2007Featured in this article: Kamlendra Singh.
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2005
Transactivation of Abl by the Crk II adapter protein requires a PNAY sequence in the Crk C-terminal SH3 domain. Reichman C, Singh K, Liu Y, Singh S, Li H, Fajardo JE, Fiser A, Birge RB. Oncogene; 24(55):8187-8199.
Date published: December 8, 2005Featured in this article: Kamlendra Singh.
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Cleavage site selection within a folded substrate by the ATP-dependent Lon protease. Ondrovičová G, Liu T, Singh K, Tian B, Li H, Gakh O, Perečko D, Janata J, Granot Z, Orly J, Kutejová E, Suzuki CK. Journal of Biological Chemistry; 280(26):25103-25110.
Date published: July 1, 2005Featured in this article: Kamlendra Singh.
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Contribution of polar residues of the J-helix in the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I (Klenow fragment): Q677 regulates the removal of terminal mismatch. Singh K, Modak MJ. Biochemistry; 44(22):8101-8110.
Date published: June 7, 2005Featured in this article: Kamlendra Singh.
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2003
A positively charged side chain at position 154 on the β8-αE loop of HIV-1 RT is required for stable ternary complex formation. Sharma B, Kaushik N, Upadhyay A, Tripathi S, Singh K, Pandey VN. Nucleic Acids Research; 31(17):5167-5174.
Date published: September 1, 2003Featured in this article: Kamlendra Singh.
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Structural analysis of the finger subdomain in DNA polymerases. Josko D, Singh K, Modak MJ. Proceedings of the International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences; 294-299.
Date published: June 23, 2003Featured in this article: Kamlendra Singh.
Phe 771 of Escherichia coli DNA polymerase I (Klenow fragment) is the major site for the interaction with the template overhang and the stabilization of the pre-polymerase ternary complex. Srivastava A, Singh K, Modak MJ. Biochemistry; 42(13):3645-3654.
Date published: April 8, 2003Featured in this article: Kamlendra Singh.
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Presence of 18-Å long hydrogen bond track in the active site of Escherichia coli DNA polymerase I (klenow fragment): Its requirement in the stabilization of enzyme-template-primer complex. Singh K, Modak MJ. Journal of Biological Chemistry; 278(13):11289-11302.
Date published: March 28, 2003Featured in this article: Kamlendra Singh.
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2002
Substitution of conserved hydrophobic residues in motifs B and C of HIV-1 RT alters the geometry of its catalytic pocket. Sharma B, Kaushik N, Singh K, Kumar S, Pandey VN. Biochemistry; 41(52):15685-15697.
Date published: December 31, 2002Featured in this article: Kamlendra Singh.
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Lysine 152 of MuLV reverse transcriptase is required for the integrity of the active site?. Shi Q, Singh K, Srivastava A, Kaushik N, Modak MJ. Biochemistry; 41(50):14831-14842.
Date published: December 17, 2002Featured in this article: Kamlendra Singh.
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Insertion of a small peptide of six amino acids into the β7-β8loop of the p51 subunit of HIV-1 reverse transcriptase perturbs theheterodimerand affects its activities. Pandey PK, Kaushik N, Singh K, Sharma B, Upadhyay AK, Kumar S, Harris D, Pandey VN. BMC Biochemistry; 3:1-14.
Date published: June 18, 2002Featured in this article: Kamlendra Singh.
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DNA polymerase I of Mycobacterium tuberculosis: Functional role of a conserved aspartate in the hinge joining the M and N helices. Arrigo CJ, Singh K, Modak MJ. Journal of Biological Chemistry; 277(3):1653-1661.
Date published: January 18, 2002Featured in this article: Kamlendra Singh.
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2000
Self-complementary motifs (SCM) in α-crystallin small heat shock proteins. Farnsworth PN, Singh K. FEBS Letters; 482(3):175-179.
Date published: October 6, 2000Featured in this article: Kamlendra Singh.
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The J-helix of Escherichia coli DNA polymerase I (Klenow fragment) regulates polymerase and 3′-5′-exonuclease functions. Tuske S, Singh K, Kaushik N, Modak MJ. Journal of Biological Chemistry; 275(31):23759-23768.
Date published: August 4, 2000Featured in this article: Kamlendra Singh.
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A carboxylate triad is essential for the polymerase activity of Escherichia coli DNA polymerase I (Klenow Fragment). Presence of two functional triads at the catalytic center. Gangurde R, Kaushik N, Singh K, Modak MJ. Journal of Biological Chemistry; 275(26):19685-19692.
Date published: June 30, 2000Featured in this article: Kamlendra Singh.
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Role of Q190 of MuLV RT in ddNTP resistance and fidelity of DNA synthesis: A molecular model of interactions with substrates. Singh K, Kaushik N, Jin J, Madhusudanan M, Modak MJ. Protein Engineering; 13(9):635-643.
Date published: January 1, 2000Featured in this article: Kamlendra Singh.
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Structure and regulation of opioid receptors. Chaturvedi K, Christoffers KH, Singh K, Howells RD. Biopolymers - Peptide Science Section; 55(4):334-346.
Date published: January 1, 2000Featured in this article: Kamlendra Singh.
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1999
Analysis of the role of glutamine 190 in the catalytic mechanism of murine leukemia virus reverse transcriptase. Jin J, Kaushik N, Singh K, Modak MJ. Journal of Biological Chemistry; 274(30):20861-20868.
Date published: July 23, 1999Featured in this article: Kamlendra Singh.
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Tyrosine 222, a member of the YXDD motif of MuLV RT, is catalytically essential and is a major component of the fidelity center. Kaushik N, Singh K, Ailuru I, Modak MJ. Biochemistry; 38(9):2617-2627.
Date published: March 2, 1999Featured in this article: Kamlendra Singh.
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1998
A unified DNA- and dNTP-binding mode for DNA polymerases. Singh K, Modak MJ. Trends in Biochemical Sciences; 23(8):277-281.
Date published: August 1, 1998Featured in this article: Kamlendra Singh.
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Interaction of DNA with bovine lens α-crystallin: Its functional implications. Singh K, Groth-Vasselli B, Farnsworth PN. International Journal of Biological Macromolecules; 22(3-4):315-320.
Date published: May 1, 1998Featured in this article: Kamlendra Singh.
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Refinement of 3D structure of bovine lens αA-crystallin. Farnsworth PN, Frauwirth H, Groth-Vasselli B, Singh K. International Journal of Biological Macromolecules; 22(3-4):175-185.
Date published: May 1, 1998Featured in this article: Kamlendra Singh.
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Effect of electrostatic interactions in recognition of acetylcholine by acetylcholinesterase. Linaras CE, Singh K, Kristol D, Ritter AB. Journal of Molecular Structure: THEOCHEM; 425(1-2):81-85.
Date published: February 19, 1998Featured in this article: Kamlendra Singh.
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Analysis of the role of gln190 in the active site of murine leukemia virus reverse transcriptase (MuLV RT). Jin J, Singh K, Modak MJ. FASEB Journal; 12(8):A1353.
Date published: January 1, 1998Featured in this article: Kamlendra Singh.
Substitution of tyr->phe in the YXDD motif of MULV-RT significantly enhances the fidelity of the enzyme. Kaushik N, Ailuru I, Singh K, Modak MJ. FASEB Journal; 12(8):A1353.
Date published: January 1, 1998Featured in this article: Kamlendra Singh.
1997
Effects of temperature and concentration on bovine lens α-crystallin secondary structure: A circular dichroism spectroscopic study. Farnsworth PN, Groth-Vasselli B, Greenfield NJ, Singh K. International Journal of Biological Macromolecules; 20(4):283-291.
Date published: July 1, 1997Featured in this article: Kamlendra Singh.
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Location and exposure of hydrophobic surfaces in relation to an ‘open’ micellar quaternary structure of alpha-crystallin. Farnsworth PN, Groth-Vasselli B, Kumosinski TF, Singh K. Experimental eye research; 64(5):853-855.
Date published: May 1, 1997Featured in this article: Kamlendra Singh.
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Interaction of dna with bovine lens cc-crystallin. Singh K, Groth-Vasselli B, Farnsworth PN. Investigative Ophthalmology and Visual Science; 38(4):S302.
Date published: January 1, 1997Featured in this article: Kamlendra Singh.
1996
A comparison of structural relationships among α-crystallin, human Hsp27, γ-crystallins and βB2-crystallin. Singh K, Zewge D, Groth-Vasselli B, Farnsworth PN. International Journal of Biological Macromolecules; 19(4):227-233.
Date published: December 1, 1996Featured in this article: Kamlendra Singh.
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Effect of thiobase incorporation into duplex DNA during the polymerization reaction. Singh K, Groth-Vasselli B, Farnsworth PN, Rai DK. Research Communications in Molecular Pathology and Pharmacology; 94(2):129-140.
Date published: November 1, 1996Featured in this article: Kamlendra Singh.
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Electrostatic parameters of the theoritical quaternary structure of bovine α-crystallin. Singh K, Groth-Vasselli B, Farnsworth PN. International Journal of Biological Macromolecules; 18(3):205-209.
Date published: April 1, 1996Featured in this article: Kamlendra Singh.
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Structural relationships among α-crystallin, human HSP27, γ-crystallins and βB2-crystallin. Singh K, Groth-Vasselli B, Farnsworth PN. Investigative Ophthalmology and Visual Science; 37(3):S598.
Date published: February 15, 1996Featured in this article: Kamlendra Singh.
Far UV-CD spectral analysis of bovine α-crystallin. Farnsworth PN, Singh K, Greenfield N, Groth-Vasselli B. Investigative Ophthalmology and Visual Science; 37(3):S598.
Date published: February 15, 1996Featured in this article: Kamlendra Singh.
1995
α-Crystallin quaternary structure: molecular basis for its chaperone activity. Singh K, Groth-Vasselli B, Kumosinski TF, Farnsworth PN. FEBS Letters; 372(2-3):283-287.
Date published: September 25, 1995Featured in this article: Kamlendra Singh.
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Advances in computer technology: Impact on the practice of medicine. Groth-Vasselli B, Singh K, Farnsworth PN. Journal of Medicine; 26(5-6):323-330.
Date published: January 1, 1995Featured in this article: Kamlendra Singh.
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1991
MINDO/3 and MNDO evaluation of bond orders and valence indices in uracil and 2-thiouracil. Singh K, Rai DK, Rai R. Journal of Molecular Structure: THEOCHEM; 235(1-2):15-19.
Date published: October 1, 1991Featured in this article: Kamlendra Singh.
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MINDO/3 and MNDO studies of some thio analogues of nucleic acid bases. Singh K, Rai DK, Yadav JS. Journal of Molecular Structure: THEOCHEM; 231(C):103-107.
Date published: June 20, 1991Featured in this article: Kamlendra Singh.
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Vibrational studies of biomolecules-III. 6-Thioguanine. Singh K, Yadav RA, Yadav JS. Spectrochimica Acta Part A: Molecular Spectroscopy; 47(6):819-820.
Date published: January 1, 1991Featured in this article: Kamlendra Singh.
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