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Kihoon Nam

Kihoon Nam

Research Assistant Professor

Phone: (573) 882-6455
kihoon.nam@health.missouri.edu
545 Bond LIfe Sciences Center

Enhanced transfection efficiency of PAMAM dendrimer by surface modification with l-arginine. Choi JS, Nam K, Park J-Y, Kim J-B, Lee J-K, Park J-S. Journal of Controlled Release; 99(3):445-456.

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Enhanced transfection of primary cortical cultures using arginine-grafted PAMAM dendrimer, PAMAM-Arg. Kim J-B, Choi JS, Nam K, Lee M, Park J-S, Lee J-K. Journal of Controlled Release; 114(1):110-117.

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HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain. Kim J-B, Joon SC, Yu Y-M, Nam K, Piao C-S, Kim S-W, Lee M-H, Han P-L, Park J-S, Lee J-K. Journal of Neuroscience; 26(24):6413-6421.

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Dexamethasone-conjugated low molecular weight polyethylenimine as a nucleus-targeting lipopolymer gene carrier. Yun MB, Choi H, Lee S, Seong HK, Young TK, Nam K, Jong SP, Lee M, Joon SC. Bioconjugate Chemistry; 18(6):2029-2036.

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Enhancement of the transfection efficiency of poly(ethylenimine) by guanidylation. Lee Y, Min YC, Mo H, Nam K, Koo H, Jin G-W, Jong SP. Bulletin of the Korean Chemical Society; 29(3):666-668.

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Extra- and intranuclear dynamics and distribution of modified-PAMAM polyplexes in living cells: A single-molecule analysis. Lee S, Nam K, Park J-S, Joon SC, Seong KE, Dong JY, Seong HK. Bulletin of the Korean Chemical Society; 29(8):1565-1568.

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Evaluation of generations 2, 3 and 4 arginine modified PAMAM dendrimers for gene delivery. Nam HY, Hahn HJ, Nam K, Choi W-H, Jeong Y, Kim D-E, Park J-S. International Journal of Pharmaceutics; 363(1-2):199-205.

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Biodegradable PAMAM ester for enhanced transfection efficiency with low cytotoxicity. Nam HY, Nam K, Hahn HJ, Kim BH, Lim HJ, Kim HJ, Choi JS, Park J-S. Biomaterials; 30(4):665-673.

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Comparison between arginine conjugated PAMAM dendrimers with structural diversity for gene delivery systems. Kim T-i, Bai CZ, Nam K, Park J-s. Journal of Controlled Release; 136(2):132-139.

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Biodegradable branched poly(ethylenimine sulfide) for gene delivery. Koo H, Jin G-w, Kang H, Lee Y, Nam K, Zhe Bai C, Park J-S. Biomaterials; 31(5):988-997.

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Neuroprotection by biodegradable PAMAM ester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain. Kim I-D, Lim C-M, Kim J-B, Nam HY, Nam K, Kim S-W, Park J-S, Lee J-K. Journal of Controlled Release; 142(3):422-430.

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Nonviral gene delivery to human ovarian cancer cells using arginine-grafted PAMAM dendrimer. Jang SH, Choi SJ, Oh JH, Chae SW, Nam K, Park JS, Lee HJ. Drug Development and Industrial Pharmacy; 37(1):41-46.

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PAMAM dendrimer with a 1,2-diaminoethane surface facilitates endosomal escape for enhanced pDNA delivery. Jin G-W, Koo H, Nam K, Kim H, Lee S, Park J-S, Lee Y. Polymer; 52(2):339-346.

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Effective healing of diabetic skin wounds by using nonviral gene therapy based on minicircle vascular endothelial growth factor DNA and a cationic dendrimer. Kwon MJ, An S, Choi S, Nam K, Jung HS, Yoon CS, Ko JH, Jun HJ, Kim TK, Jung SJ, Park JH, Lee Y, Park J-S. Journal of Gene Medicine; 14(4):272-278.

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Dendrimer type bio-reducible polymer for efficient gene delivery. Nam HY, Nam K, Lee M, Kim SW, Bull DA. Journal of Controlled Release; 160(3):592-600.

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Polymeric delivery of therapeutic RAE-1 plasmid to the pancreatic islets for the prevention of type 1 diabetes. Joo WS, Jeong JH, Nam K, Blevins KS, Salama ME, Kim SW. Journal of Controlled Release; 162(3):606-611.

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Paclitaxel-conjugated PEG and arginine-grafted bioreducible poly (disulfide amine) micelles for co-delivery of drug and gene. Nam K, Nam HY, Kim P-H, Kim SW. Biomaterials; 33(32):8122-8130.

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Human erythropoietin gene delivery for cardiac remodeling of myocardial infarction in rats. Lee Y, McGinn AN, Olsen CD, Nam K, Lee M, Shin SK, Kim SW. Journal of Controlled Release; 171(1):24-32.

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Hypoxia/hepatoma dual specific suicide gene expression plasmid delivery using bio-reducible polymer for hepatocellular carcinoma therapy. Kim HA, Nam K, Lee M, Kim SW. Journal of Controlled Release; 171(1):1-10.

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Nonviral gene therapy in vivo with PAM-RG4/ apoptin as a potential brain tumor therapeutic. An S, Nam K, Choi S, Bai CZ, Lee Y, Park J-S. International Journal of Nanomedicine; 8:821-834.

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Arginine modified PAMAM dendrimer for interferon beta gene delivery to malignant glioma. Bai CZ, Choi S, Nam K, An S, Park J-S. International Journal of Pharmaceutics; 445(1-2):79-87.

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Post-translational regulation of a hypoxia-responsive VEGF plasmid for the treatment of myocardial ischemia. Won Y-W, McGinn AN, Lee M, Nam K, Bull DA, Kim SW. Biomaterials; 34(26):6229-6238.

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Synergistically combined gene delivery for enhanced VEGF secretion and antiapoptosis. Won Y-W, Lee M, Kim HA, Nam K, Bull DA, Kim SW. Molecular Pharmaceutics; 10(10):3676-3683.

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Enhanced gene delivery system using disulfide-linked chitosan immobilized with polyamidoamine. Nam K, Park JW, Bark H, Han J, Nah J-W, Jang M-K, Kim SW. Macromolecular Research; 22(4):370-376.

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Tumor targeting RGD conjugated bio-reducible polymer for VEGF siRNA expressing plasmid delivery. Kim HA, Nam K, Kim SW. Biomaterials; 35(26):7543-7552.

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Ultrasound-assisted siRNA delivery via arginine-grafted bioreducible polymer and microbubbles targeting VEGF for ovarian cancer treatment. Florinas S, Kim J, Nam K, Janát-Amsbury MM, Kim SW. Journal of Controlled Release; 183(1):1-8.

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Oncolytic adenovirus coated with multidegradable bioreducible core-cross-linked polyethylenimine for cancer gene therapy. Choi J-W, Nam J-P, Nam K, Lee YS, Yun C-O, Kim SW. Biomacromolecules; 16(7):2132-2143.

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Effective gene delivery into human stem cells with a cell-targeting peptide-modified bioreducible polymer. Beloor J, Ramakrishna S, Nam K, Seon Choi C, Kim J, Kim SH, Cho HJ, Shin HS, Kim H, Kim SW, Lee S-K, Kumar P. Small; 11(17):2069-2079.

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Evaluation of Histidylated Arginine-Grafted Bioreducible Polymer to Enhance Transfection Efficiency for Use as a Gene Carrier. Nam J-P, Nam K, Nah J-W, Kim SW. Molecular Pharmaceutics; 12(7):2352-2364.

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Evaluation of dendrimer type bio-reducible polymer as a siRNA delivery carrier for cancer therapy. Nam J-P, Nam K, Jung S, Nah J-W, Kim SW. Journal of Controlled Release; 209:179-185.

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VEGF therapeutic gene delivery using dendrimer type bio-reducible polymer into human mesenchymal stem cells (hMSCs). Kim H, Nam K, Nam J-P, Kim HS, Kim YM, Joo WS, Kim SW. Journal of Controlled Release; 220:222-228.

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Hepatoma targeting peptide conjugated bio-reducible polymer complexed with oncolytic adenovirus for cancer gene therapy. Choi J-W, Kim HA, Nam K, Na Y, Yun C-O, Kim S. Journal of Controlled Release; 220:691-703.

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Poly(ethylenimine) conjugated bioreducible dendrimer for efficient gene delivery. Nam K, Jung S, Nam J-P, Kim SW. Journal of Controlled Release; 220:447-455.

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Factorial Design Based Multivariate Modeling and Optimization of Tunable Bioresponsive Arginine Grafted Poly(cystaminebis(acrylamide)-diaminohexane) Polymeric Matrix Based Nanocarriers. Yang R, Nam K, Kim SW, Turkson J, Zou Y, Zuo YY, Haware RV, Chougule MB. Molecular Pharmaceutics; 14(1):252-263.

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Synergistic antitumor effect mediated by a paclitaxel-conjugated polymeric micelle-coated oncolytic adenovirus. Kasala D, Lee S-H, Hong JW, Choi J-W, Nam K, Chung YH, Kim SW, Yun C-O. Biomaterials; 145:207-222.

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Post-irradiated human submandibular glands display high collagen deposition, disorganized cell junctions, and an increased number of adipocytes. Nam K, Maruyama CL, Trump BG, Buchmann L, Hunt JP, Monroe MM, Baker OJ. Journal of Histochemistry and Cytochemistry; 64(6):343-352.

Featured in this article: Kihoon Nam, Olga Baker.

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Laminin-111 Peptides Conjugated to Fibrin Hydrogels Promote Formation of Lumen Containing Parotid Gland Cell Clusters. Nam K, Jones JP, Lei P, Andreadis ST, Baker OJ. Biomacromolecules; 17(6):2293-2301.

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L1 Peptide-Conjugated Fibrin Hydrogels Promote Salivary Gland Regeneration. Nam K, Wang C-S, Maruyama CLM, Lei P, Andreadis ST, Baker OJ. Journal of Dental Research; 96(7):798-806.

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Laminin-111-derived peptide conjugated fibrin hydrogel restores salivary gland function. Nam K, Maruyama CL, Wang C-S, Trump BG, Lei P, Andreadis ST, Baker OJ. PLoS ONE; 12(11):e0187069.

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Synergistic effects of laminin-1 peptides, VEGF and FGF9 on salivary gland regeneration. Nam K, Dean SM, Brown CT, Smith RJ Jr, Lei P, Andreadis ST, Baker OJ. Acta Biomaterialia; 91:186-194.

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Aspirin Triggered Resolvin D1 reduces inflammation and restores saliva secretion in a Sjögren’s syndrome mouse model. Dean S, Wang C-S, Nam K, Maruyama CL, Trump BG, Baker OJ. Rheumatology (United Kingdom); 58(7):1285-1292.

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Using cell sheets to regenerate mouse submandibular glands. Nam K, Kim K, Dean SM, Brown CT, Davis RS, Okano T, Baker OJ. npj Regenerative Medicine; 4(1):16.

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Engineering the mode of morphogenetic signal presentation to promote branching from salivary gland spheroids in 3D hydrogels. Samuel RZ, Lei P, Nam K, Baker OJ, Andreadis ST. Acta Biomaterialia; 105:121-130.

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Sex-dependent Regeneration Patterns in Mouse Submandibular Glands. Brown CT, Nam K, Zhang Y, Qiu Y, Dean SM, Dos Santos HT, Lei P, Andreadis ST, Baker OJ. Journal of Histochemistry and Cytochemistry; 68(5):305-318.

Featured in this article: Kihoon Nam, Harim Tavares dos Santos, Olga Baker.

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Cell Sheets Restore Secretory Function in Wounded Mouse Submandibular Glands. Dos Santos HT, Kim K, Okano T, Camden JM, Weisman GA, Baker OJ, Nam K. Cells; 9(12).

Featured in this article: Harim Tavares dos Santos, Jean Camden, Gary Weisman, Olga Baker, Kihoon Nam.

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Trimers Conjugated to Fibrin Hydrogels Promote Salivary Gland Function. Dos Santos HT, Nam K, Brown CT, Dean SM, Lewis S, Pfeifer CS, Lei P, Petris MJ, Andreadis ST, Baker OJ. Journal of Dental Research; 100(3):268-275.

Featured in this article: Harim Tavares dos Santos, Kihoon Nam, Michael Petris, Olga Baker.

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