Archive
Donald H. Burke-Agüero
Research Interests The Burke lab explores the many roles of ribonucleic acid, or RNA. This substance has long been known to function in cells to help copy genetic information from DNA, but scientists increasingly recognize many other tasks that RNA carries out. The lab pushes the boundaries of what is possible to achieve with RNA. From using aptamers to target cancer, using ribozymes to explore the RNA origins of life on Earth, and using protein engineering to understand RNA-protein interactions in viral replication, a theme that unifies the lab’s projects is the relationships among macromolecular sequence, function, selection pressures,…
Gary A. Weisman
Research Interests The Weisman laboratory studies the initiation of chronic inflammatory disorders such as autoimmune and cardiovascular diseases and cancer, and they have found that blocking cell receptors that recognize the release of the molecule ATP from damaged cells prevents chronic inflammation which preserves tissue function. In mouse models of autoimmune Sjogren’s disease, they have demonstrated that inhibiting these ATP receptors prevents chronic immune cell activation in salivary and lacrimal gland to enhance saliva and tear secretion, respectively. Recently, they demonstrated that blocking the ATP receptors also retards tumor growth in mice, and they are now testing whether these approaches…
Trupti Joshi
Research Interests The Joshi lab has expertise in the areas of bioinformatics and its application to biomedical sciences, plants sciences, animal sciences, and health informatics fields. The lab has three key research pillars: Multiomics Informatics Data Analytics and Framework Development Multiomics Informatics Method Development Multiomics Data Integration Tool Development…