University of Missouri

July 6, 2017

Paige Gruenke #IAmScience

Paige Gruenke, a Ph.D candidate in Dr. Donald Burke’s lab in Bond LSC. | Photo by Mary Jane Rogers, Bond LSC By Mary Jane Rogers | Bond LSC “#IAmScience because I am fascinated by life on a molecular level and inspired that my research could positively impact medicine.” As a graduate student in Donald Burke’s lab at Bond LSC, Paige Gruenke explores the role of ribonucleic acid, or RNA. That means her work involves a lot of test tubes. She looks at how specialized RNA molecules, called aptamers, bind tightly and specifically to proteins from HIV…

Nov. 25, 2015

You shall not pass: the basic science of blocking HIV

  Marc Johnson, associate professor of molecular microbiology and immunology at the Bond Life Sciences Center, studies viruses such as HIV. | photo by Jennifer Lu, Bond LSC Nineteen colorful foam flowers decorate the walls of Marc Johnson’s office, a memento from his lab members when they “redecorated” while he was out of town. Each flower is labeled in bold Sharpie with the names of viruses and viral proteins that his lab studies—MLV, RSV, Gag, Pol, to name a few. One flower stands out, marked in capital letters: H-I-V. Johnson, an associate professor of molecular microbiology…

June 5, 2015

Filling in the gaps of HIV

By Caleb O’Brien | MU Bond Life Sciences Center The HIV capsid protein (shown above in an array of hexagons) plays a critical role in the virus life cycle. Bond LSC researchers recently developed the most complete model yet of this vital protein.  Image by Karen Kirby and Anna Gres Seeing the whole picture can mean a lot when it comes to figuring out HIV. Researchers at the University of Missouri Bond Life Sciences Center are gaining a clearer idea of what a key protein in HIV looks like, which will help explain…

Aug. 26, 2014

Holding on: Bond LSC scientist discovers protein prevents release of HIV and other viruses from infected cells

Shan-Lu Liu, Bond LSC scientist and associate professor in the MU School of Medicine’s Department of Molecular Microbiology and Immunology. Courtesy Justin Kelley, University of Missouri Health System. Shan-Lu Liu initially thought it was a mistake when a simple experiment kept failing. But that serendipitous accident led the Bond Life Sciences Center researcher to discover how a protein prevents mature HIV from leaving a cell. Proceedings of the National Academy of Sciences published this research online Aug. 18. “It’s a striking phenomena caused by this particular protein,” Liu said. “The HIV is already assembled inside…

Aug. 4, 2014

Viruses as Vehicles: Finding what drives

Graduate students Yuleam Song and Dan Salamango inoculate a bacteria culture in Johnson’s lab. The inoculation takes a small portion of a virus and multiplies the sample, allowing researchers to custom-make viruses. By Madison Knapp | Bond Life Sciences Center summer intern Modern science has found a way to turn viruses —tiny, dangerous weapons responsible for runny noses, crippling stomach pains and worldwide epidemics such as AIDS— into a tool. Gene therapy centers on the idea that scientists can hijack viruses and use them as vehicles to deliver DNA to organs in the body that…

April 28, 2014

A drug that packs a punch: new compound works better against resistant HIV

Bond LSC researcher Stefan Sarafianos stands in the LSC atrium. The virologist is an associate professor of molecular microbiology and immunology and Chancellor’s Chair of Excellence in Molecular Virology with appointments in MU’s School of Medicine and the Department of Biochemistry. Resistance is the price of success when it comes to treating HIV. Virologists at the Bond Life Sciences Center are helping to test the next generation of anti-AIDS medication to quell that resistance. Stefan Sarafianos’ lab recently proved that EFdA, a compound that stops HIV from spreading, is 70 times more potent against some HIV…