University of Missouri

July 1, 2021

A scientist steps away from the bench

After 40 years of hard work, it is finally time for David Pintel to pass the torch. Dr. David Pintel, retiring after 40 years at Bond LSC, takes in his office during his last week at Bond LSC. | photo by Davis Suppes, Bond LSC By Davis Suppes| Bond LSC David Pintel is hanging up his lab coat after 40 years.   “It’s been an honor to be able to do my work at the University of Missouri. I’ve had a great group of colleagues both here and at the medical school,”…

July 20, 2018

#IAmScience K’Imani Davis

By Erica Overfelt | Bond LSC From hate to passion. One class changed senior K’Imani Davis’s mind, who is now going into her senior year working in the Anand Chandrasekhar lab at Bond LSC. “I used to actually hate science, and when I say hate, I hated it,” Davis said. “Senior year of high school I took AP Bio, I loved it. I don’t know what happened, but I started to try and I liked the subject.” After Davis’s change of heart, she decided to start out at MU as a biology major, and she is now going…

May 15, 2017

BPA rewires the sex of turtle brains

By Jinghong Chen | Bond Life Sciences Center Painted turtle eggs were brought from a hatchery in Louisiana, candled to ensure embryo viability and then incubated at male-permissive temperatures in a bed of vermiculite. Those exposed to BPA developed deformities to testes that held female characteristics.Photo by Roger Meissen | © 2015 – MU Bond Life Sciences Center Cool dudes, hot mommas. This is the underlying concept behind sex development in painted turtles, a species that lacks sex chromosomes. A painted turtle’s sex is determined by temperature at which the eggs are incubated at…

Sep. 2, 2016

Building blocks of life in the lab could revolutionize life for us all

NASA, NIH-funded work seeks to understand bio-chemical mechanisms of life on Earth, and among the stars By Phillip Sitter | Bond LSC Donald Burke-Agüero stands in his office in Bond LSC, holding a model of an RNA protein structure. Burke-Agüero studies the bio-chemical functions of RNA, and how those functions might be able to be artificially designed or replicated. | Phillip Sitter, Bond LSC Any child obsessed with Legos knows the fun of creation bound only by imagination and the size or variety of the blocks within their pile. For some scientists, that spirit extends…

Aug. 15, 2016

Research Core offers new capabilities

Grand opening highlights specialty of large-scale metabolite profiling By Phillip Sitter | Bond LSC Dr. Zhentian Lei , assistant director and assistant research professor of the MU Metabolomics Center, provides an overview of an ultra high-pressure liquid chromatograph coupled to mass spectrometry for the large-scale profiling of metabolites at the University of Missouri Metabolomics Center open house on Aug. 12. | photo by Zivile Raskauskaite, Bond LSC You might think you’ve entered the inside of a pinball machine for a moment when you enter lab 243 at the Bond Life Sciences Center. But the wires…

March 1, 2016

Unmasking the unknown

Scientists explore genetic similarities between plants and mice University of Missouri PhD Candidate Daniel L. Leuchtman peers through an Arabidopsis plant. Leuchtman has been experimenting with replacing a gene in the plants immune system with a similar gene from mice. | Photograph by Justin L. Stewart/MU Bond Life Sciences Center By Justin L. Stewart | MU Bond Life Sciences Center Almost two-thirds of what makes a human a human and a fly a fly are the same, according to the NIH genome research institute. If recent research at the University of Missouri’s Bond…

Nov. 25, 2015

You shall not pass: the basic science of blocking HIV

  Marc Johnson, associate professor of molecular microbiology and immunology at the Bond Life Sciences Center, studies viruses such as HIV. | photo by Jennifer Lu, Bond LSC Nineteen colorful foam flowers decorate the walls of Marc Johnson’s office, a memento from his lab members when they “redecorated” while he was out of town. Each flower is labeled in bold Sharpie with the names of viruses and viral proteins that his lab studies—MLV, RSV, Gag, Pol, to name a few. One flower stands out, marked in capital letters: H-I-V. Johnson, an associate professor of molecular microbiology…

April 16, 2015

BPA overrides temperature to decide turtle sex

The environmental build-up of bisphenol A (BPA) can result in a life-changing shift for aquatic animals. For painted turtles, exposure to this chemical can disrupt sexual differentiation,, according to new research in the  General and Comparative Endocrinology. Scientists at the University of Missouri have teamed up to show how low levels of certain endocrine disruptors like BPA can cause males to possess female gonadal structures in newly-hatched turtles. This collaboration between MU, Westminster College, the U.S. Geological Survey (USGS) and the Saint Louis Zoo exposed turtle eggs to levels of BPA similar to those currently found in the environment.

Nov. 20, 2014

“Mutant seeds” blossom in the pollen research field

A mutant arabidopsis model nearing pollination. Mutant arabidopsis models under lamps in Shuqun Zhang’s lab. Three-month-old mutant arabidopsis models are used to study the function of pollen. The thought of pollen dispersed throughout the air might trigger horrific memories of allergies, but the drifting dander is absolutely essential to all life. Science has long linked this element of reproduction with environmental conditions, but the reasons why and how pollen functions were less understood. Now lingering questions about the nuanced control of plants are being answered. “Pollen is a very important part of the reproductive process and…

June 20, 2014

Nerve cell communication mechanisms uncovered, may lead to new therapeutic approaches for neurodegenerative diseases

  Story by Madison Knapp/ Bond Life Sciences summer intern Simple actions like walking, swallowing and breathing are the result of a complex communication system between cells. When we touch something hot, our nerve cells tell us to take our hand off the object. This happens in a matter of milliseconds. This hyperspeed of communication is instrumental in maintaining proper muscle function. Many degenerative diseases affecting millions of people worldwide result from reduced signaling speed or other cellular miscommunications within this intricate network. Michael Garcia, investigator at the Christopher S. Bond Life Sciences Center and associate professor of biology at…

June 10, 2014

SoyKB: Leading the convergence of wet and dry science in the era of Big Data

Yaya Cui, an investigator in plant sciences at the Bond Life Sciences Center examines data on fast neuron soybean mutants that are represented on the SoyKB database. The most puzzling scientific mysteries may be solved at the same machine you’re likely reading this sentence. In the era of “Big Data” many significant scientific discoveries — the development of new drugs to fight diseases, strategies of agricultural breeding to solve world-hunger problems and figuring out why the world exists — are being made without ever stepping foot in a lab. Developed by researchers at the Bond Life…