University of Missouri

June 10, 2014

SoyKB: Leading the convergence of wet and dry science in the era of Big Data

Yaya Cui, an investigator in plant sciences at the Bond Life Sciences Center examines data on fast neuron soybean mutants that are represented on the SoyKB database. The most puzzling scientific mysteries may be solved at the same machine you’re likely reading this sentence. In the era of “Big Data” many significant scientific discoveries — the development of new drugs to fight diseases, strategies of agricultural breeding to solve world-hunger problems and figuring out why the world exists — are being made without ever stepping foot in a lab. Developed by researchers at the Bond Life…

June 4, 2014

MU Scientists Successfully Transplant, Grow Stem Cells in Pigs

New line of pigs do not reject transplants, will allow for future research on stem cell therapies Story by Nathan Hurst/MU News Bureau COLUMBIA, Mo. – One of the biggest challenges for medical researchers studying the effectiveness of stem cell therapies is that transplants or grafts of cells are often rejected by the hosts. This rejection can render experiments useless, making research into potentially life-saving treatments a long and difficult process. Now, researchers at the University of Missouri have shown that a new line of genetically modified pigs will host transplanted cells without the risk of rejection.

May 12, 2014

New screening tool gives scientists more control over genetic research

A tangled spool of yarn represents DNA, while the fingers holding the section represent the insulators just added by MU researchers to improve a scientific, screening tool. | Paige Blankenbuehler Here’s a scenario: You are trying to find a lost section of string in the world’s most massively tangled spool of yarn. Then try cutting that section of yarn that’s deeply embedded in the mess without inadvertently cutting another or losing track of the piece you’re after. For researchers, this problem is not unlike something they encounter in the study of genetic information in the tangled…

May 6, 2014

Trail to a Cure, Inc. helps fund training of future scientists, physcians

Over the weekend, Bond LSC HIV researchers Stefan Sarafianos, Marc Johnson and Donald Burke-Aguero joined Trail to a Cure, Inc., a Columbia nonprofit organization that helped fund important HIV research. Since 2008, the organization has raised $74,000 for HIV/AIDS research, with some of that funding going directly to the Bond LSC providing additional hours of lab research. The 2014 online fundraising is still open and donations can be made to Trail to a Cure, Inc. until the end of the month. The funding from Trail to a Cure helps Bond LSC researchers train future scientists and physicians in labs and…

April 28, 2014

A drug that packs a punch: new compound works better against resistant HIV

Bond LSC researcher Stefan Sarafianos stands in the LSC atrium. The virologist is an associate professor of molecular microbiology and immunology and Chancellor’s Chair of Excellence in Molecular Virology with appointments in MU’s School of Medicine and the Department of Biochemistry. Resistance is the price of success when it comes to treating HIV. Virologists at the Bond Life Sciences Center are helping to test the next generation of anti-AIDS medication to quell that resistance. Stefan Sarafianos’ lab recently proved that EFdA, a compound that stops HIV from spreading, is 70 times more potent against some HIV…

April 25, 2014

Frogs help researchers find genetic mechanism for mildew susceptibility in grapevine

Powdery mildew on a cabernet sauvignon grapevine leaf. | USDA Grape genetics publications and research A princess kisses a frog and it turns into a prince, but when a scientist uses a frog to find out more information about a grapevine disease, it turns into the perfect tool narrowing in on the cause of crop loss of Vitis vinifera, the world’s favorite connoisseur wine-producing varietal. MU researchers recently published a study that uncovered a specific gene in the Vitis vinifera varietal Cabernet Sauvingon, that contributes to its susceptibility to a widespread plant disease, powdery mildew.

April 24, 2014

Chemical beacons: LSC scientist discovers how plants beckon bacteria to attack

Scott Peck, Bond LSC scientist and associate professor of biochemistry, studies Arabidopsis and how bacteria perceive it before initiating an infection. Roger Meissen/ Bond LSC Sometimes plants inadvertently roll out the red carpet for bacteria. Researchers at the University of Missouri Bond Life Sciences Center recently discovered how a plant’s own chemicals act as a beacon to bacteria, triggering an infection. Proceedings of the National Academy of Sciences published their study April 21. “When bacteria recognize these plant chemicals it builds a needle-like syringe that injects 20-30 proteins into its host, shutting down the plant’s…

April 22, 2014

Bond LSC Investigator Chris Pires in Shanghai, Wuhan

Recently, one of our investigators, J. Chris Pires traveled to Fudan University in Shanghai and the Wuhan Vegetable Research Institute for the 19th annual Crucifer Genetic Workshop and Brassica 2014 Conference in Wuhan, China. Pires was invited to the esteemed event as the keynote speaker of the Brassica Conference. He led workshops as part of the three-day conference March 30 through April 2 and also visited Fudan University in Shanghai during the trip. Pires is an associate professor in biological sciences and focuses much of his research on the evolution of plants. His talk at Fudan University discussed his research…

March 25, 2014

Bond LSC staff prepares boat for April 12 fundraiser

Made completely of cardboard and Popeye themed, Bond LSC facilities crew say this boat could be the winner of the 3rd Annual Flot Your Boat for the Food Bank Race on April 12 — BLANKENBUEHLER Every year the College of Agriculture, Food and Natural Resources puts on a Float Your Boat for the Food Bank Race. All proceeds go to the Columbia Food Bank and last year, with 45 participants, more than $17,000 was donated.  All participants craft their own boat and obey one golden rule: cardboard only. The Bond LSC crew are returning to…

March 25, 2014

Choi honored for distinguished dissertation

Jeongmin Choi (left), Gary Stacey (center) and postdoc Kiwamu Tanaka recently discovered the first plant receptor for extracellular ATP. Choi received the 2014 Distinguished Dissertation Award for her part in this work. A former Bond LSC graduate student is being recognized for a dissertation that stands out from the crowd. Jeongmin Choi received the 2014 Distinguished Dissertation Award this month from MU’s Graduate Faculty Senate for her work identifying the first plant receptor for extracellular ATP. The journal Science published Choi’s “Identification of a plant receptor for extracellular ATP”  Jan. 17, 2014. Choi completed her dissertation working as…

March 21, 2014

MU researchers find key gene in spinal locomotion, yield insight on paralysis

Samuel Waters and graduate researcher Desiré Buckley review stages of embryonic development. — BLANKENBUEHLER The difference between walking and being paralyzed could be as simple as turning a light switch on and off, a culmination of years of research shows. Recently, University of Missouri Assistant Professor of biology Samuel T. Waters isolated a coding gene that he found has profound effects on locomotion and central nervous system development. Waters’ work with gene expression in embryonic mouse tissue could shed light on paralysis and stroke and other disorders of the central nervous system, like Alzheimer’s disease. Waters…

March 11, 2014

Strong symposium start by Skloot

Karin Loftin, MU Chancellor R. Bowen Loftin, Bond Life Sciences Director Jack Shultz and Tim Evans pose with Rebecca Skloot at the University of Missouri Monday evening — BLANKENBUEHLER The bridge between public knowledge and the inner-workings of the science community is one that many are reluctant to cross. Sometimes riddled with confusing terms, the most exciting discoveries aren’t always approachable. The 10th annual MU Life Sciences & Society Symposium began Monday evening with Rebecca Skloot as she spoke to a nearly full house at Jesse Auditorium Monday. Every year the symposium erases the line between community…