Archive
David Mendoza
Research Interests The Mendoza lab focuses on the identification of the molecular mechanisms mediating nutrient sensing and allocation in plants, particularly nutrient elements that are required for photosynthesis, such as iron, copper, and zinc.
Gary A. Weisman
Research Interests The Weisman laboratory studies the initiation of chronic inflammatory disorders such as autoimmune and cardiovascular diseases and cancer, and they have found that blocking cell receptors that recognize the release of the molecule ATP from damaged cells prevents chronic inflammation which preserves tissue function. In mouse models of autoimmune Sjogren’s disease, they have demonstrated that inhibiting these ATP receptors prevents chronic immune cell activation in salivary and lacrimal gland to enhance saliva and tear secretion, respectively. Recently, they demonstrated that blocking the ATP receptors also retards tumor growth in mice, and they are now testing whether these approaches…
Dong Xu
Research Interests Dr. Xu’s lab focuses on the interface between bioinformatics and deep learning. It works on development of novel computational methods, algorithms, software and information systems, as well as on broad applications of these tools and other informatics resources for various biological and medical problems. Several successful applications of deep learning by the lab in bioinformatics span areas such as single-cell data analysis, protein structure prediction, protein language models, protein localization prediction, predicting sites of protein post-translational modifications, elucidating genotype-phenotype associations, understanding biological pathways through image analysis in published literature, and analyzing tongue images for health evaluations.
Trupti Joshi
Research Interests The Joshi lab has expertise in the areas of bioinformatics and its application to biomedical sciences, plants sciences, animal sciences, and health informatics fields. The lab has three key research pillars: Multiomics Informatics Data Analytics and Framework Development Multiomics Informatics Method Development Multiomics Data Integration Tool Development…
William and Wendy Picking
Research Interests Vaccines are perhaps the greatest public health achievement of our lifetime. They have prevented millions of deaths from childhood and adult diseases to the point that some pathogens have almost been eradicated. Unfortunately, there is much work that still needs to be done to develop more vaccines that can be delivered intranasally and thus prevent some of the vaccine hesitancy exhibited throughout the world. Furthermore, many vaccines can be formulated to be therapeutic and can thus treat a person and vaccinate in one motion, which aids in compliance to the vaccine schedule. The Picking lab aims to…
Marc Libault
Research Interests Plant cells differentially use their genetic information to gain their specific function. Libault has a long-term interest in understanding the differential use of the genome between plant cells and its dynamic regulation during plant development and in response to environmental stresses. Gaining this information is essential to understand gene function and the regulation of their expression, and, therefore, to implement well-sounded synthetic biology strategies to enhance desirable crop traits. …
Chris and Monique Lorson
Research Interests The Lorson lab is comprised of several research teams largely centered on translational medicine and neurodegenerative diseases including Spinal Muscular Atrophy (SMA), SMA with Respiratory Distress (SMARD), Charcot-Marie-Tooth (CMT), and others. Current projects include: Development of a novel drug for SMA — a splice-switching antisense oligonucleotide — that dramatically extends survival in SMA animal models from a single dose at birth. Identification of genes and pathways that improve the SMA/SMARD phenotypes, such as Plastin-3 or alpha-synuclein and then validating these factors using AAV-mediated gene therapy. Small molecule development in collaboration with the Androphy lab (IUPUI) and the Hodgetts…