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William Picking

Professor, Veterinary Pathobiology

Phone: (573) 882-6550
pickingw@missouri.edu

William Picking is a professor of Veterinary Pathobiology in the College of Veterinary Medicine

Picking investigates the molecules and structures used by pathogenic bacteria to cause disease in humans and animals.  His main focus is on specialized structures called type III secretion systems (T3SS) that pathogens such as Shigella, Salmonella and Pseudomonas use to communicate with host cells to alter their normal behavior for the benefit of the pathogen. 

For example, Shigella flexneri uses T3SS to promote uptake by the cells of the large intestine and then to escape into the cell’s cytoplasm, where this pathogen grows and spreads to neighboring cells.  The result is potentially severe bacillary dysentery, commonly seen around the world.  The T3SS “injectisome” literally resembles a syringe and needle and it is used to inject specialized proteins into target cells to alter the host’s normal cellular functions.  This work has revealed important information on how these nanomachines function uncovered targets that are laying the foundation for the development of future anti-infective agents and vaccines.

2021

Effect of Two Unique Nanoparticle Formulations on the Efficacy of a Broadly Protective Vaccine Against Pseudomonas Aeruginosa. howlader, Debaki R., Das Sayan, Lu,Ti, Hu, Gang, Varisco, David J., Dietz, Zackary K. Walton, Sierra P., Rathnakaram, Siva Sai Kumar, Gardner, Francesca M., Ernst, Robert k., Picking William D, Picking Wendy L.. Frontiers in Pharmacology; Volume 18.

Date published: August 18, 2021
Featured in this article: Wendy Picking, William Picking.

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Composition and Biophysical Properties of the Sorting Platform Pods in the Shigella Type III Secretion System. Tachiyama, Shoichia, Skaar, Ryana, Chang, Yunjieb, c;Carroll, Brittany L., Muthuramalingam, Meenakumaria;Whittier, Sean K.;Barta, Michael L,Picking, Wendy L.;Liu, Junb, Picking, William D.. Frontiers in Cellular and Infection Microbiology; Volume 11.

Date published: June 3, 2021
Featured in this article: William Picking, Wendy Picking.

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The shigella type iii secretion system: An overview from top to bottom. Muthuramalingam, Meenakumari, Whittier, Sean K., Picking, Wendy L, Picking, William D.. Microorganisms; Volume 9, Issue 2, Pages 1 - 27.

Date published: February 1, 2021
Featured in this article: Wendy Picking, William Picking.

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Optimization of RG1-VLP vaccine performance in mice with novel TLR4 agonists. Zacharia, Athina; Harberts, Erin; Valencia, Sarah M.; Myers, Breana; Sanders, Chelsea;Jain, Akshay; Larson, Nicholas R. ; Middaugh, C. Russell ; Picking, William D.; Difilippantonio, Simone; Kirnbauer, Reinhard ; Roden, Richard B.. Vaccine; Volume 39, Issue 2, Pages 292 - 302.

Date published: January 8, 2021
Featured in this article: William Picking, Wendy Picking.

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Preformulation Characterization and the Effect of Ionic Excipients on the Stability of a Novel DB Fusion Protein. Jain, A., Hu, G., Kumar Ratnakaram, S.S., . Picking, W.L., Middaugh, C.R.. Journal of Pharmaceutical Sciences ; 110(1), pp. 108–123.

Date published: January 1, 2021
Featured in this article: William Picking, Wendy Picking.

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