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Monique Lorson

Monique Lorson

Associate Research Professor, Veterinary Pathobiology

Phone: (573) 884-2219 or (573) 884-2680 (lab)
LorsonM@missouri.edu
440C Bond Life Sciences Center

Monique Lorson is an associate research professor of veterinary pathobiology. Her current focus is to develop a swine model of spinal muscular atrophy (SMA) for evaluating novel therapeutics. Large animal models are especially important because often cell-based models and rodents do not accurately reflect the complete human condition, not to mention the logistics involved in “scaling up” from a rodent to a human. Pigs are more similar to humans in size, physiology, metabolism, cardiac output, immune response and the nervous system. Lorson is generating two pig SMA models for evaluating treatments and will soon begin therapeutic studies. For this project, Lorson has developed a collaborative research team spanning multiple colleges and departments at MU. The goal is to provide investigators with a“tool” to systematically evaluate delivery parameters and effectiveness of new treatments, within the context of a single animal model, for a more efficient and successful bench-to-bedside translation.

2013

Genetically engineered pig models for human diseases. Prather RS, Lorson M, Ross JW, Whyte JJ, Walters E. Annual Review of Animal Biosciences; 1:203-219.

Date published: January 1, 2013
Featured in this article: Monique Lorson.

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2012

SMN-inducing compounds for the treatment of spinal muscular atrophy. Lorson MA, Lorson CL. Future Medicinal Chemistry; 4(16):2067-2084.

Date published: October 1, 2012
Featured in this article: Monique Lorson, Christian Lorson.

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2011

Disruption of the Survival Motor Neuron (SMN) gene in pigs using ssDNA. Lorson MA, Spate LD, Samuel MS, Murphy CN, Lorson CL, Prather RS, Wells KD. Transgenic Research; 20(6):1293-1304.

Date published: December 1, 2011
Featured in this article: Monique Lorson, Christian Lorson.

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2009

C. elegans mitotic cyclins have distinct as well as overlapping functions in chromosome segregation. Van Der Voet M, Lorson MA, Srinivasan DG, Bennett KL, Van Den Heuvel S. Cell Cycle; 8(24):4091-4102.

Date published: December 15, 2009
Featured in this article: Monique Lorson.

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2008

Identification and characterisation of a nuclear localisation signal in the SMN associated protein, Gemin4. Lorson MA, Dickson AM, Shaw DJ, Todd AG, Young EC, Morse R, Wolstencroft C, Lorson CL, Young PJ. Biochemical and Biophysical Research Communications; 375(1):33-37.

Date published: October 10, 2008
Featured in this article: Monique Lorson, Christian Lorson.

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Identification and characterization of the porcine (Sus scrofa) survival motor neuron (SMN1) gene: An animal model for therapeutic studies. Lorson MA, Spate LD, Prather RS, Lorson CL. Developmental Dynamics; 237(8):2268-2278.

Date published: August 1, 2008
Featured in this article: Monique Lorson, Christian Lorson.

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Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing. Novoyatleva T, Heinrich B, Tang Y, Benderska N, Butchbach MER, Lorson CL, Lorson MA, Ben-Dov C, Fehlbaum P, Bracco L, Burghes AHM, Bollen M, Stamm S. Human Molecular Genetics; 17(1):52-70.

Date published: January 1, 2008
Featured in this article: Christian Lorson, Monique Lorson.

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2004

Identification of critical domains and putative partners for the Caenorhabditis elegans spindle component LIN-5. Fisk Green R, Lorson M, Walhout AJM, Vidal M, Van Den Heuvel S. Human Genetics and Genomics; 271(5):532-544.

Date published: June 1, 2004
Featured in this article: Monique Lorson.

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2000

LIN-5 is a novel component of the spindle apparatus required for chromosome segregation and cleavage plane specification in Caenorhabditis elegans. Lorson MA, Horvitz HR, Van Den Heuvel S. Journal of Cell Biology; 148(1):73-86.

Date published: January 10, 2000
Featured in this article: Monique Lorson.

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GATEWAY recombinational cloning: Application to the cloning of large numbers of open reading frames or ORFeomes. Walhout AJM, Temple GF, Brasch MA, Hartley JL, Lorson MA, Van den Heuvel S, Vidal M. Methods in Enzymology; 328:575-592.

Date published: January 1, 2000
Featured in this article: Monique Lorson.

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