540d Life Sciences Center
The Petris lab investigates how minerals are accumulated within the body at the right locations and in the right concentrations. Certain conditions such as Alzheimer’s disease, cancer and microbial infection disrupt the cellular balance of minerals that may exacerbate the pathology or improve outcome. The Petris lab is focused on copper. This essential mineral is critical for many metabolic processes, including consumption of oxygen to generate of ATP, the energy source of the cell. However, it is potentially toxic if pathways that regulate its handling are dysfunctional. Using cells and animal models, the Petris lab is interested in how copper functions in Alzheimer’s disease, tumor growth, and microbial killing by the immune system.