Skip to navigation Skip to sub-navigation Skip to content

People

Michael J. Petris

Michael J. Petris

Professor of Biochemistry

Phone: 573-882-9685
petrism@missouri.edu
540d Life Sciences Center

The Petris lab investigates how minerals are accumulated within the body at the right locations and in the right concentrations. Certain conditions such as Alzheimer’s disease, cancer and microbial infection disrupt the cellular balance of minerals that may exacerbate the pathology or improve outcome. The Petris lab is focused on copper. This essential mineral is critical for many metabolic processes, including consumption of oxygen to generate of ATP, the energy source of the cell. However, it is potentially toxic if pathways that regulate its handling are dysfunctional. Using cells and animal models, the Petris lab is interested in how copper functions in Alzheimer’s disease, tumor growth, and microbial killing by the immune system.

News about Michael J. Petris

Ceruloplasmin as a source of Cu for a fungal pathogen. Besold AN, Shanbhag V, Petris MJ, Culotta VC. Journal of Inorganic Biochemistry; 219:111424.

Featured in this article: Vinit Shanbhag, Michael Petris.

Go to article...

Trimers Conjugated to Fibrin Hydrogels Promote Salivary Gland Function. Dos Santos HT, Nam K, Brown CT, Dean SM, Lewis S, Pfeifer CS, Lei P, Petris MJ, Andreadis ST, Baker OJ. Journal of Dental Research; 100(3):268-275.

Featured in this article: Harim Tavares dos Santos, Kihoon Nam, Michael Petris, Olga Baker.

Go to article...

Copper metabolism as a unique vulnerability in cancer. Shanbhag VC, Gudekar N, Jasmer K, Papageorgiou C, Singh K, Petris MJ. Biochimica et Biophysica Acta - Molecular Cell Research; 1868(2):118893.

Featured in this article: Vinit Shanbhag, Nikita Gudekar, Kimberly Jasmer, Kamlendra Singh, Michael Petris.

Go to article...

Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess. Gudekar N, Shanbhag V, Wang Y, Ralle M, Weisman GA, Petris MJ. Scientific Reports; 10(1):7856.

Featured in this article: Nikita Gudekar, Vinit Shanbhag, Gary Weisman, Michael Petris.

Go to article...

P2Y2 receptors mediate nucleotide-induced EGFR phosphorylation and stimulate proliferation and tumorigenesis of head and neck squamous cell carcinoma cell lines. Woods LT, Jasmer KJ, Muñoz Forti K, Shanbhag VC, Camden JM, Erb L, Petris MJ, Weisman GA. Oral Oncology; 109:104808.

Featured in this article: Lucas Woods, Kimberly Jasmer, Kevin Muñoz Forti, Vinit Shanbhag, Jean Camden, Michael Petris, Gary Weisman.

Go to article...

Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice. Guthrie LM, Soma S, Yuan S, Silva A, Zulkifli M, Snavely TC, Greene HF, Nunez E, Lynch B, de Ville C, Shanbhag V, Lopez FR, Acharya A, Petris MJ, Kim B-E, Gohil VM, Sacchettini JC. Science; 368(6491):620-625.

Featured in this article: Vinit Shanbhag, Michael Petris.

Go to article...

Changes in mammalian copper homeostasis during microbial infection. Culbertson EM, Khan AA, Muchenditsi A, Lutsenko S, Sullivan DJ, Petris MJ, Cormack BP, Culotta VC. Metallomics; 12(3):416-426.

Featured in this article: Aslam Khan, Michael Petris.

Go to article...

Adipocyte-specific disruption of ATPase copper transporting α in mice accelerates lipoatrophy. Tao C, Wang Y, Zhao Y, Pan J, Fan Y, Liang X, Cao C, Zhao J, Petris MJ, Li K, Wang Y. Diabetologia; 62(12):2340-2353.

Featured in this article: Michael Petris.

Go to article...

ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis. Shanbhag V, Jasmer-McDonald K, Zhu S, Martin AL, Gudekar N, Khan A, Ladomersky E, Singh K, Weisman GA, Petris MJ. Proceedings of the National Academy of Sciences of the United States of America; 116(14):6836-6841.

Featured in this article: Vinit Shanbhag, Kimberly Jasmer, Nikita Gudekar, Aslam Khan, Kamlendra Singh, Gary Weisman, Michael Petris.

Go to article...

An extracellular histidine-containing motif in the zinc transporter ZIP4 plays a role in zinc sensing and zinc-induced endocytosis in mammalian cells. Chun H, Korolnek T, Lee C-J, Coyne HJ III, Winge DR, Kim B-E, Petris MJ. Journal of Biological Chemistry; 294(8):2815-2826.

Featured in this article: Michael Petris.

Go to article...

P2Y2R deletion ameliorates sialadenitis in IL-14α-transgenic mice. Woods LT, Camden JM, Khalafalla MG, Petris MJ, Erb L, Ambrus JL Jr, Weisman GA. Oral Diseases; 24(5):761-771.

Featured in this article: Lucas Woods, Jean Camden, Michael Petris, Gary Weisman.

Go to article...

Rare Disease Mechanisms Identified by Genealogical Proteomics of Copper Homeostasis Mutant Pedigrees. Zlatic SA, Vrailas-Mortimer A, Gokhale A, Carey LJ, Scott E, Burch R, McCall MM, Rudin-Rush S, Davis JB, Hartwig C, Werner E, Li L, Petris M, Faundez V. Cell Systems; 6(3):368-380.e6.

Featured in this article: Michael Petris.

Go to article...

The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart. Baker ZN, Jett K, Boulet A, Hossain A, Cobine PA, Kim B-E, El Zawily AM, Lee L, Tibbits GF, Petris MJ, Leary SC. Human Molecular Genetics; 26(23):4617-4628.

Featured in this article: Michael Petris.

Go to article...

A 37-year-old Menkes disease patient—Residual ATP7A activity and early copper administration as key factors in beneficial treatment. Tümer Z, Petris M, Zhu S, Mercer J, Bukrinski J, Bilz S, Baerlocher K, Horn N, Møller LB. Clinical Genetics; 92(5):548-553.

Featured in this article: Michael Petris.

Go to article...

P2X7 receptor antagonism prevents IL-1 release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy. Khalafalla MG, Woods LT, Camden JM, Khan AA, Limesand KH, Petris MJ, Erb L, Weisman GA. Journal of Biological Chemistry; 292(40):16626-16637.

Featured in this article: Lucas Woods, Jean Camden, Aslam Khan, Michael Petris, Gary Weisman.

Go to article...

Host and pathogen copper-transporting P-type ATPases function antagonistically during Salmonella infection. Ladomersky E, Khan A, Shanbhag V, Cavet JS, Chan J, Weisman GA, Petris MJ. Infection and Immunity; 85(9):e00351-17.

Featured in this article: Aslam Khan, Vinit Shanbhag, Gary Weisman, Michael Petris.

Go to article...

A role for the ATP7A copper transporter in tumorigenesis and cisplatin resistance. Zhu S, Shanbhag V, Wang Y, Lee J, Petris M. Journal of Cancer; 8(11):1952-1958.

Featured in this article: Vinit Shanbhag, Michael Petris.

Go to article...

The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors. Comstra HS, McArthy J, Rudin-Rush S, Hartwig C, Gokhale A, Zlatic SA, Blackburn JB, Werner E, Petris M, D’Souza P, Panuwet P, Barr DB, Lupashin V, Vrailas-Mortimer A, Faundez V. eLife; 6:e24722.

Featured in this article: Michael Petris.

Go to article...

Multiple di-leucines in the ATP7A copper transporter are required for retrograde trafficking to the trans-Golgi network. Zhu S, Shanbhag V, Hodgkinson VL, Petris MJ. Metallomics; 8(9):993-1001.

Featured in this article: Vinit Shanbhag, Michael Petris.

Go to article...

The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: A new canine model for copper-metabolism disorders. Fieten H, Gill Y, Martin AJ, Concilli M, Dirksen K, Van Steenbeek FG, Spee B, Van Den Ingh TSGAM, Martens ECCP, Festa P, Chesi G, Van De Sluis B, Houwen RHJH, Watson AL, Aulchenko YS, Hodgkinson VL, Zhu S, Petris MJ, Polishchuk RS, Leegwater PAJ, Rothuizen J. DMM Disease Models and Mechanisms; 9(1):25-38.

Featured in this article: Michael Petris.

Go to article...

Autonomous requirements of the Menkes disease protein in the nervous system. Hodgkinson VL, Zhu S, Wang Y, Ladomersky E, Nickelson K, Weisman GA, Lee J, Gitlin JD, Petris MJ. American Journal of Physiology - Cell Physiology; 309(10):660-668.

Featured in this article: Gary Weisman, Michael Petris.

Go to article...

Molecular basis of neurodegeneration and neurodevelopmental defects in Menkes disease. Zlatic S, Comstra HS, Gokhale A, Petris MJ, Faundez V. Neurobiology of Disease; 81:154-161.

Featured in this article: Michael Petris.

Go to article...

X-linked spinal muscular atrophy in mice caused by autonomous loss of ATP7A in the motor neuron. Hodgkinson VL, Dale JM, Garcia ML, Weisman GA, Lee J, Gitlin JD, Petris MJ. Journal of Pathology; 236(2):241-250.

Featured in this article: Gary Weisman, Michael Petris.

Go to article...

Copper tolerance and virulence in bacteria. Ladomersky E, Petris MJ. Metallomics; 7(6):957-964.

Featured in this article: Michael Petris.

Go to article...

Increased Expression of TGF-β Signaling Components in a Mouse Model of Fibrosis Induced by Submandibular Gland Duct Ligation. Woods LT, Camden JM, El-Sayed FG, Khalafalla MG, Petris MJ, Erb L, Weisman GA. PLoS ONE; 10(5):e0123641.

Featured in this article: Lucas Woods, Jean Camden, Michael Petris, Gary Weisman.

Go to article...

Omeprazole, a gastric proton pump inhibitor, inhibits melanogenesis by blocking ATP7A trafficking. Matsui MS, Petris MJ, Niki Y, Karaman-Jurukovska N, Muizzuddin N, Ichihashi M, Yarosh DB. Journal of Investigative Dermatology; 135(3):834-841.

Featured in this article: Michael Petris.

Go to article...

The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis. Hlynialuk CJ, Ling B, Baker ZN, Cobine PA, Yu LD, Boulet A, Wai T, Hossain A, ElZawily AM, McFie PJ, Stone SJ, Diaz F, Moraes CT, Viswanathan D, Petris MJ, Leary SC. Cell Reports; 10(6):933-943.

Featured in this article: Michael Petris.

Go to article...

Separation of zinc-dependent and zinc-independent events during early LPS-stimulated TLR4 signaling in macrophage cells. Wan Y, Petris MJ, Peck SC. FEBS Letters; 588(17):2928-2935.

Featured in this article: Michael Petris, Scott Peck.

Go to article...

P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells. El-Sayed FG, Camden JM, Woods LT, Khalafalla MG, Petris MJ, Erb L, Weisman GA. American Journal of Physiology - Cell Physiology; 307(1):C83-C96.

Featured in this article: Jean Camden, Lucas Woods, Michael Petris, Gary Weisman.

Go to article...

Loss of P2Y2 nucleotide receptors enhances early pathology in the TgCRND8 mouse model of Alzheimer’s disease. Ajit D, Woods LT, Camden JM, Thebeau CN, El-Sayed FG, Greeson GW, Erb L, Petris MJ, Miller DC, Sun GY, Weisman GA. Molecular Neurobiology; 49(2):1031-1042.

Featured in this article: Lucas Woods, Jean Camden, Michael Petris, Gary Weisman.

Go to article...

Up-regulation and activation of the P2Y2 nucleotide receptor mediate neurite extension in IL-1β-treated mouse primary cortical neurons. Peterson TS, Thebeau CN, Ajit D, Camden JM, Woods LT, Wood WG, Petris MJ, Sun GY, Erb L, Weisman GA. Journal of Neurochemistry; 125(6):885-896.

Featured in this article: Jean Camden, Lucas Woods, Michael Petris, Gary Weisman.

Go to article...

Maternofetal and neonatal copper requirements revealed by enterocyte-specific deletion of the Menkes disease protein. Wang Y, Zhu S, Hodgkinson V, Prohaska JR, Weisman GA, Gitlin JD, Petris MJ. American Journal of Physiology - Gastrointestinal and Liver Physiology; 303(11):G1236-G1244.

Featured in this article: Gary Weisman, Michael Petris.

Go to article...

P2X7 receptor activation induces inflammatory responses in salivary gland epithelium. Woods LT, Camden JM, Batek JM, Petris MJ, Erb L, Weisman GA. American Journal of Physiology - Cell Physiology; 303(7):C790-C801.

Featured in this article: Lucas Woods, Jean Camden, Michael Petris, Gary Weisman.

Go to article...

Conditional knockout of the menkes disease copper transporter demonstrates its critical role in embryogenesis. Wang Y, Zhu S, Weisman GA, Gitlin JD, Petris MJ. PLoS ONE; 7(8):e43039.

Featured in this article: Gary Weisman, Michael Petris.

Go to article...

Copper homeostasis at the host-pathogen interface. Hodgkinson V, Petris MJ. Journal of Biological Chemistry; 287(17):13549-13555.

Featured in this article: Michael Petris.

Go to article...

Nucleotides released from Aβ 1-42-treated microglial cells increase cell migration and Aβ 1-42 uptake through P2Y 2 receptor activation. Kim HJ, Ajit D, Peterson TS, Wang Y, Camden JM, Wood WG, Sun GY, Erb L, Petris M, Weisman GA. Journal of Neurochemistry; 121(2):228-238.

Featured in this article: Jean Camden, Michael Petris, Gary Weisman.

Go to article...

Advances in the understanding of mammalian copper transporters. Wang Y, Hodgkinson V, Zhu S, Weisman GA, Petris MJ. Advances in Nutrition; 2(2):129-137.

Featured in this article: Gary Weisman, Michael Petris.

Go to article...

Rat parotid gland cell differentiation in three-dimensional culture. Baker OJ, Schulz DJ, Camden JM, Liao Z, Peterson TS, Seye CI, Petris MJ, Weisman GA. Tissue Engineering - Part C: Methods; 16(5):1135-1144.

Featured in this article: Olga Baker, Jean Camden, Cheikh Seye, Michael Petris, Gary Weisman.

Go to article...

Altered microglial copper homeostasis in a mouse model of Alzheimer’s disease. Zheng Z, White C, Lee J, Peterson TS, Bush AI, Sun GY, Weisman GA, Petris MJ. Journal of Neurochemistry; 114(6):1630-1638.

Featured in this article: Gary Weisman, Michael Petris.

Go to article...

P2Y2 nucleotide receptor-mediated responses in brain cells. Peterson TS, Camden JM, Wang Y, Seye CI, Wood WG, Sun GY, Erb L, Petris MJ, Weisman GA. Molecular Neurobiology; 41(2-3):356-366.

Featured in this article: Jean Camden, Cheikh Seye, Michael Petris, Gary Weisman.

Go to article...

P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells. Ratchford AM, Baker OJ, Camden JM, Rikka S, Petris MJ, Seye CI, Erb L, Weisman GA. Journal of Biological Chemistry; 285(10):7545-7555.

Featured in this article: Olga Baker, Jean Camden, Michael Petris, Cheikh Seye, Gary Weisman.

Go to article...

A role for the ATP7A copper-transporting ATPase in macrophage bactericidal activity. White C, Lee J, Kambe T, Fritsche K, Petris MJ. Journal of Biological Chemistry; 284(49):33949-33956.

Featured in this article: Michael Petris.

Go to article...

Copper transport into the secretory pathway is regulated by oxygen in macrophages. White C, Kambe T, Fulcher YG, Sachdev SW, Bush AI, Fritsche K, Lee J, Quinn TP, Petris MJ. Journal of Cell Science; 122(9):1315-1321.

Featured in this article: Thomas Quinn, Michael Petris.

Go to article...

Phenotypic diversity of Menkes disease in mottled mice is associated with defects in localisation and trafficking of the ATP7A protein. Kim B-E, Petris MJ. Journal of Medical Genetics; 44(10):641-646.

Featured in this article: Michael Petris.

Go to article...

A histidine-rich cluster mediates the ubiquitination and degradation of the human zinc transporter, hZIP4, and protects against zinc cytotoxicity. Mao X, Kim B-E, Wang F, Eide DJ, Petris MJ. Journal of Biological Chemistry; 282(10):6992-7000.

Featured in this article: Michael Petris.

Go to article...

The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells. Wang F, Kim B-E, Petris MJ, Eide DJ. Journal of Biological Chemistry; 279(49):51433-51441.

Featured in this article: Michael Petris.

Go to article...

Cisplatin stabilizes a multimeric complex of the human Ctr1 copper transporter: Requirement for the extracellular methionine-rich clusters. Guo Y, Smith K, Petris MJ. Journal of Biological Chemistry; 279(45):46393-46399.

Featured in this article: Michael Petris.

Go to article...

Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cells. Greenough M, Pase L, Voskoboinik I, Petris MJ, O'Brien AW, Camakaris J. American Journal of Physiology - Cell Physiology; 287(5):C1463-C1471.

Featured in this article: Michael Petris.

Go to article...

Zinc-stimulated endocytosis controls activity of the mouse ZIP1 and ZIP3 zinc uptake transporters. Wang F, Dufner-Beattie J, Kim B-E, Petris MJ, Andrews G, Eide DJ. Journal of Biological Chemistry; 279(23):24631-24639.

Featured in this article: Michael Petris.

Go to article...

Identification of Methionine-rich Clusters That Regulate Copper-stimulated Endocytosis of the Human Ctr1 Copper Transporter. Guo Y, Smith K, Lee J, Thiele DJ, Petris MJ. Journal of Biological Chemistry; 279(17):17428-17433.

Featured in this article: Michael Petris.

Go to article...

Acrodermatitis enteropathica mutations affect transport activity, localization and zinc-responsive trafficking of the mouse ZIP4 zinc transporter. Wang F, Kim B-E, Dufner-Beattie J, Petris MJ, Andrews G, Eide DJ. Human Molecular Genetics; 13(5):563-571.

Featured in this article: Michael Petris.

Go to article...

Zn2+-stimulated Endocytosis of the mZIP4 Zinc Transporter Regulates Its Location at the Plasma Membrane. Kim B-E, Wang F, Dufner-Beattie J, Andrews GK, Eide DJ, Petris MJ. Journal of Biological Chemistry; 279(6):4523-4530.

Featured in this article: Michael Petris.

Go to article...

Studies on endocytic mechanisms of the Menkes copper-translocating P-type ATPase (ATP7A; MNK): Endocytosis of the Menkes protein. Lane C, Petris MJ, Benmerah A, Greenough M, Camakaris J. BioMetals; 17(1):87-98.

Featured in this article: Michael Petris.

Go to article...

The SLC31 (Ctr) copper transporter family. Petris MJ. Pflügers Archiv - Eur J Physiol; 447(5):752-755.

Featured in this article: Michael Petris.

Go to article...

A copper treatable Menkes disease mutation associated with defective trafficking of a functional Menkes copper ATPase. Kim B-E, Smith K, Petris MJ. Journal of Medical Genetics; 40(4):290-295.

Featured in this article: Michael Petris.

Go to article...

Copper-stimulated endocytosis and degradation of the human copper transporter, hCtr1. Petris MJ, Smith K, Lee J, Thiele DJ. Journal of Biological Chemistry; 278(11):9639-9646.

Featured in this article: Michael Petris.

Go to article...

Function and regulation of the mammalian copper-transporting ATPases: Insights from biochemical and cell biological approaches. Lutsenko S, Petris MJ. Journal of Membrane Biology; 191(1):1-12.

Featured in this article: Michael Petris.

Go to article...

Copper-regulated trafficking of the Menkes disease copper ATPase is associated with formation of a phosphorylated catalytic intermediate. Petris MJ, Voskoboinik I, Cater M, Smith K, Kim B-E, Llanos RM, Strausak D, Camakaris J, Mercer JFB. Journal of Biological Chemistry; 277(48):46736-46742.

Featured in this article: Michael Petris.

Go to article...

A conditional mutation affecting localization of the Menkes disease copper ATPase: Suppression by copper supplementation. Kim B-E, Smith K, Meagher CK, Petris MJ. Journal of Biological Chemistry; 277(46):44079-44084.

Featured in this article: Michael Petris.

Go to article...

Characterization of mouse embryonic cells deficient in the Ctr1 high affinity copper transporter: Identification of a Ctr1-independent copper transport system. Lee J, Petris MJ, Thiele DJ. Journal of Biological Chemistry; 277(43):40253-40259.

Featured in this article: Michael Petris.

Go to article...

The Menkes copper transporter is required for the activation of tyrosinase. Petris MJ, Strausak D, Mercer JFB. Human Molecular Genetics; 9(19):2845-2851.

Featured in this article: Michael Petris.

Go to article...

Erratum: Functional analysis of the N-terminal CXXC metal-binding motifs in the human Menkes copper-transporting P-type ATPase expressed in cultured mammalian cells (Journal of Biological Chemistry (1999) 274 (22008-22012)). Voskoboinik I, Strausak D, Greenough M, Brooks H, Petris M, Smith S, Mercer JF, Camakaris J. Journal of Biological Chemistry; 274(50):36030.

Featured in this article: Michael Petris.

Go to article...

The Menkes protein (ATP7A; MNK) cycles via the plasma membrane both in basal and elevated extracellular copper using a C-terminal di-leucine endocytic signal. Petris MJ, Mercer JFB. Human Molecular Genetics; 8(11):2107-2115.

Featured in this article: Michael Petris.

Go to article...

Functional analysis of the N-terminal CXXC metal-binding motifs in the human Menkes copper-transporting P-type ATPase expressed in cultured mammalian cells. Voskoboinik I, Strausak D, Greenough M, Brooks H, Petris M, Smith S, Mercer JF, Camakaris J. Journal of Biological Chemistry; 274(31):22008-22012.

Featured in this article: Michael Petris.

Go to article...

The cell biology of the menkes disease protein. Petris MJ, Mercer JFB, Camakaris J. Advances in Experimental Medicine and Biology; 448:53-66.

Featured in this article: Michael Petris.

Go to article...

A C-terminal di-leucine is required for localization of the Menkes protein in the trans-Golgi network. Petris MJ, Camakaris J, Greenough M, LaFontaine S, Mercer JFB. Human Molecular Genetics; 7(13):2063-2071.

Featured in this article: Michael Petris.

Go to article...

Correction of the copper transport defect of Menkes patient fibroblasts by expression of the menkes and Wilson ATPases. La Fontaine S, Firth SD, Camakaris J, Englezou A, Theophilos MB, Petris MJ, Howie M, Lockhart PJ, Greenough M, Brooks H, Reddel RR, Mercer JFB. Journal of Biological Chemistry; 273(47):31375-31380.

Featured in this article: Michael Petris.

Go to article...

Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: A novel mechanism of regulated trafficking. Petris MJ, Mercer JFB, Culvenor JG, Lockhart P, Gleeson PA, Camakaris J. EMBO Journal; 15(22):6084-6095.

Featured in this article: Michael Petris.

Go to article...

Gene amplification of the menkes (MNK; ATP7A) P-type ATPase gene of CHO cells is associated with copper resistance and enhanced copper efflux. Camakaris J, Petris MJ, Bailey L, Shen P, Lockhart P, Glover TW, Barcroft CL, Patton J, Mercer JFB. Human Molecular Genetics; 4(11):2117-2123.

Featured in this article: Michael Petris.

Go to article...