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Gary A. Weisman

Gary A. Weisman

Curators' Distinguished Professor, Biochemistry

Phone: 573-882-5005
weismang@missouri.edu
540e Bond Life Sciences Center

The Weisman lab studies the relationship between inflammatory disease and “nucleotide receptors,” which are present on the surface of most cells. Nucleotide receptors control a range of functions including platelet aggregation, muscle contraction, neurotransmission, insulin secretion, wound healing, and cell growth. The lab has several ongoing investigations. In one project, researchers study the mechanism by which one specific nucleotide receptor subtype can prevent plaque formation and nerve degeneration associated with Alzheimer’s disease. Another project is determining the role of a different nucleotide receptor subtype in the development of Sjögren’s syndrome, a disease of the salivary gland that causes loss of saliva secretion. The lab is exploring new methods to regenerate salivary glands from single cells in animal models of Sjögren’s syndrome. Researchers are also looking at the relationship between a nucleotide receptor subtype and changes in blood vessel function that are associated with the early stages of atherosclerosis and diabetes.

News about Gary A. Weisman

2021

P2Y receptors for extracellular nucleotides: Contributions to cancer progression and therapeutic implications. Woods LT, Forti KM, Shanbhag VC, Camden JM, Weisman GA. Biochemical Pharmacology; 187:114406.

Date published: May 1, 2021
Featured in this article: Lucas Woods, Kevin Muñoz Forti, Vinit Shanbhag, Jean Camden, Gary Weisman.

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Evolution, correlation, structural impact and dynamics of emerging SARS-CoV-2 variants. Spratt AN, Kannan SR, Woods LT, Weisman GA, Quinn TP, Lorson CL, Sönnerborg A, Byrareddy SN, Singh K. Computational and Structural Biotechnology Journal; 19:3799-3809.

Date published: January 1, 2021
Featured in this article: Lucas Woods, Gary Weisman, Thomas Quinn, Christian Lorson, Kamlendra Singh.

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2020

Cell Sheets Restore Secretory Function in Wounded Mouse Submandibular Glands. Dos Santos HT, Kim K, Okano T, Camden JM, Weisman GA, Baker OJ, Nam K. Cells; 9(12).

Date published: December 9, 2020
Featured in this article: Harim Tavares dos Santos, Jean Camden, Gary Weisman, Olga Baker, Kihoon Nam.

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Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess. Gudekar N, Shanbhag V, Wang Y, Ralle M, Weisman GA, Petris MJ. Scientific Reports; 10(1):7856.

Date published: December 1, 2020
Featured in this article: Nikita Gudekar, Vinit Shanbhag, Gary Weisman, Michael Petris.

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P2Y2 receptors mediate nucleotide-induced EGFR phosphorylation and stimulate proliferation and tumorigenesis of head and neck squamous cell carcinoma cell lines. Woods LT, Jasmer KJ, Muñoz Forti K, Shanbhag VC, Camden JM, Erb L, Petris MJ, Weisman GA. Oral Oncology; 109:104808.

Date published: October 1, 2020
Featured in this article: Lucas Woods, Kimberly Jasmer, Kevin Muñoz Forti, Vinit Shanbhag, Jean Camden, Michael Petris, Gary Weisman.

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2019

ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis. Shanbhag V, Jasmer-McDonald K, Zhu S, Martin AL, Gudekar N, Khan A, Ladomersky E, Singh K, Weisman GA, Petris MJ. Proceedings of the National Academy of Sciences of the United States of America; 116(14):6836-6841.

Date published: April 2, 2019
Featured in this article: Vinit Shanbhag, Kimberly Jasmer, Nikita Gudekar, Aslam Khan, Kamlendra Singh, Gary Weisman, Michael Petris.

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2018

P2Y2R deletion ameliorates sialadenitis in IL-14α-transgenic mice. Woods LT, Camden JM, Khalafalla MG, Petris MJ, Erb L, Ambrus JL Jr, Weisman GA. Oral Diseases; 24(5):761-771.

Date published: July 1, 2018
Featured in this article: Lucas Woods, Jean Camden, Michael Petris, Gary Weisman.

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2017

P2X7 receptor antagonism prevents IL-1 release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy. Khalafalla MG, Woods LT, Camden JM, Khan AA, Limesand KH, Petris MJ, Erb L, Weisman GA. Journal of Biological Chemistry; 292(40):16626-16637.

Date published: October 6, 2017
Featured in this article: Lucas Woods, Jean Camden, Aslam Khan, Michael Petris, Gary Weisman.

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Host and pathogen copper-transporting P-type ATPases function antagonistically during Salmonella infection. Ladomersky E, Khan A, Shanbhag V, Cavet JS, Chan J, Weisman GA, Petris MJ. Infection and Immunity; 85(9):e00351-17.

Date published: September 1, 2017
Featured in this article: Aslam Khan, Vinit Shanbhag, Gary Weisman, Michael Petris.

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2016

Phytochemicals and botanical extracts regulate NF-κB and Nrf2/ARE reporter activities in di TNC1 astrocytes. Ajit D, Simonyi A, Li R, Chen Z, Hannink M, Fritsche KL, Mossine VV, Smith RE, Dobbs TK, Luo R, Folk WR, Gu Z, Lubahn DB, Weisman GA, Sun GY. Neurochemistry International; 97:49-56.

Date published: July 1, 2016
Featured in this article: Mark Hannink, Gary Weisman.

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2015

Autonomous requirements of the Menkes disease protein in the nervous system. Hodgkinson VL, Zhu S, Wang Y, Ladomersky E, Nickelson K, Weisman GA, Lee J, Gitlin JD, Petris MJ. American Journal of Physiology - Cell Physiology; 309(10):660-668.

Date published: November 15, 2015
Featured in this article: Gary Weisman, Michael Petris.

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X-linked spinal muscular atrophy in mice caused by autonomous loss of ATP7A in the motor neuron. Hodgkinson VL, Dale JM, Garcia ML, Weisman GA, Lee J, Gitlin JD, Petris MJ. Journal of Pathology; 236(2):241-250.

Date published: June 1, 2015
Featured in this article: Gary Weisman, Michael Petris.

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Increased Expression of TGF-β Signaling Components in a Mouse Model of Fibrosis Induced by Submandibular Gland Duct Ligation. Woods LT, Camden JM, El-Sayed FG, Khalafalla MG, Petris MJ, Erb L, Weisman GA. PLoS ONE; 10(5):e0123641.

Date published: May 1, 2015
Featured in this article: Lucas Woods, Jean Camden, Michael Petris, Gary Weisman.

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2014

P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells. El-Sayed FG, Camden JM, Woods LT, Khalafalla MG, Petris MJ, Erb L, Weisman GA. American Journal of Physiology - Cell Physiology; 307(1):C83-C96.

Date published: July 1, 2014
Featured in this article: Jean Camden, Lucas Woods, Michael Petris, Gary Weisman.

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Loss of P2Y2 nucleotide receptors enhances early pathology in the TgCRND8 mouse model of Alzheimer’s disease. Ajit D, Woods LT, Camden JM, Thebeau CN, El-Sayed FG, Greeson GW, Erb L, Petris MJ, Miller DC, Sun GY, Weisman GA. Molecular Neurobiology; 49(2):1031-1042.

Date published: April 1, 2014
Featured in this article: Lucas Woods, Jean Camden, Michael Petris, Gary Weisman.

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2013

Up-regulation and activation of the P2Y2 nucleotide receptor mediate neurite extension in IL-1β-treated mouse primary cortical neurons. Peterson TS, Thebeau CN, Ajit D, Camden JM, Woods LT, Wood WG, Petris MJ, Sun GY, Erb L, Weisman GA. Journal of Neurochemistry; 125(6):885-896.

Date published: June 1, 2013
Featured in this article: Jean Camden, Lucas Woods, Michael Petris, Gary Weisman.

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2012

Replacement of huntingtin exon 1 by trans-splicing. Rindt H, Yen P-F, Thebeau CN, Peterson TS, Weisman GA, Lorson CL. Cellular and Molecular Life Sciences; 69(24):4191-4204.

Date published: December 1, 2012
Featured in this article: Gary Weisman, Christian Lorson.

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Maternofetal and neonatal copper requirements revealed by enterocyte-specific deletion of the Menkes disease protein. Wang Y, Zhu S, Hodgkinson V, Prohaska JR, Weisman GA, Gitlin JD, Petris MJ. American Journal of Physiology - Gastrointestinal and Liver Physiology; 303(11):G1236-G1244.

Date published: December 1, 2012
Featured in this article: Gary Weisman, Michael Petris.

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P2X7 receptor activation induces inflammatory responses in salivary gland epithelium. Woods LT, Camden JM, Batek JM, Petris MJ, Erb L, Weisman GA. American Journal of Physiology - Cell Physiology; 303(7):C790-C801.

Date published: October 1, 2012
Featured in this article: Lucas Woods, Jean Camden, Michael Petris, Gary Weisman.

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Conditional knockout of the menkes disease copper transporter demonstrates its critical role in embryogenesis. Wang Y, Zhu S, Weisman GA, Gitlin JD, Petris MJ. PLoS ONE; 7(8):e43039.

Date published: August 10, 2012
Featured in this article: Gary Weisman, Michael Petris.

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Nucleotides released from Aβ 1-42-treated microglial cells increase cell migration and Aβ 1-42 uptake through P2Y 2 receptor activation. Kim HJ, Ajit D, Peterson TS, Wang Y, Camden JM, Wood WG, Sun GY, Erb L, Petris M, Weisman GA. Journal of Neurochemistry; 121(2):228-238.

Date published: April 1, 2012
Featured in this article: Jean Camden, Michael Petris, Gary Weisman.

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2011

Advances in the understanding of mammalian copper transporters. Wang Y, Hodgkinson V, Zhu S, Weisman GA, Petris MJ. Advances in Nutrition; 2(2):129-137.

Date published: March 1, 2011
Featured in this article: Gary Weisman, Michael Petris.

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2010

Rat parotid gland cell differentiation in three-dimensional culture. Baker OJ, Schulz DJ, Camden JM, Liao Z, Peterson TS, Seye CI, Petris MJ, Weisman GA. Tissue Engineering - Part C: Methods; 16(5):1135-1144.

Date published: October 1, 2010
Featured in this article: Olga Baker, Jean Camden, Cheikh Seye, Michael Petris, Gary Weisman.

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Altered microglial copper homeostasis in a mouse model of Alzheimer’s disease. Zheng Z, White C, Lee J, Peterson TS, Bush AI, Sun GY, Weisman GA, Petris MJ. Journal of Neurochemistry; 114(6):1630-1638.

Date published: September 1, 2010
Featured in this article: Gary Weisman, Michael Petris.

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P2Y2 nucleotide receptor-mediated responses in brain cells. Peterson TS, Camden JM, Wang Y, Seye CI, Wood WG, Sun GY, Erb L, Petris MJ, Weisman GA. Molecular Neurobiology; 41(2-3):356-366.

Date published: June 1, 2010
Featured in this article: Jean Camden, Cheikh Seye, Michael Petris, Gary Weisman.

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P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells. Ratchford AM, Baker OJ, Camden JM, Rikka S, Petris MJ, Seye CI, Erb L, Weisman GA. Journal of Biological Chemistry; 285(10):7545-7555.

Date published: March 5, 2010
Featured in this article: Olga Baker, Jean Camden, Michael Petris, Cheikh Seye, Gary Weisman.

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2009

Interleukin-1β enhances nucleotide-induced and α-secretase- dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y2 receptor. Kong Q, Peterson TS, Baker O, Stanley E, Camden J, Seye CI, Erb L, Simonyi A, Wood WG, Sun GY, Weisman GA. Journal of Neurochemistry; 109(5):1300-1310.

Date published: June 1, 2009
Featured in this article: Olga Baker, Jean Camden, Cheikh Seye, Gary Weisman.

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2008

Proinflammatory cytokines tumor necrosis factor-α and interferon-γ alter tight junction structure and function in the rat parotid gland Par-C10 cell line. Baker OJ, Camden JM, Redman RS, Jones JE, Seye CI, Erb L, Weisman GA. American Journal of Physiology - Cell Physiology; 295(5):C1191-C1201.

Date published: November 1, 2008
Featured in this article: Olga Baker, Jean Camden, Cheikh Seye, Gary Weisman.

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Corrigendum to “P2Y2 nucleotide receptor activation up-regulates vascular cell adhesion molecular-1 expression and enhances lymphocyte adherence to a human submandibular gland cell line” [Mol. Immunol. 45 (2008) 65-75] (DOI:10.1016/j.molimm.2007.05.009). Baker OJ, Camden JM, Rome DE, Seye CI, Weisman GA. Molecular Immunology; 45(11):3319.

Date published: June 1, 2008
Featured in this article: Olga Baker, Jean Camden, Cheikh Seye, Gary Weisman.

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P2Y2 nucleotide receptor activation up-regulates vascular cell adhesion molecular-1 expression and enhances lymphocyte adherence to a human submandibular gland cell line. Baker OJ, Camden JM, Rome DE, Seye CI, Weisman GA. Molecular Immunology; 45(1):65-75.

Date published: January 1, 2008
Featured in this article: Olga Baker, Jean Camden, Cheikh Seye, Gary Weisman.

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2006

Differential coupling of the P2Y1 receptor to Gα14 and Gαq/11 proteins during the development of the rat salivary gland. Baker OJ, Camden JM, Ratchford AM, Seye CI, Erb L, Weisman GA. Archives of Oral Biology; 51(5):359-370.

Date published: May 1, 2006
Featured in this article: Olga Baker, Jean Camden, Cheikh Seye, Gary Weisman.

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