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David G. Mendoza-Cózatl

David G. Mendoza-Cózatl

Associate Professor, Plant Sciences

Phone: 573-882-1892
mendozad@missouri.edu
271f Bond Life Sciences Center

David Mendoza is an assistant professor of plant sciences and a member of the Interdisciplinary Plant Group (IPG). He studies the molecular and biochemical mechanisms by which plants resist and accumulate heavy metals. Plants and seeds are the main source of essential metals – zinc, iron, magnesium and copper – and also the main entry point into the food chain for toxic elements such as cadmium, lead, arsenic and mercury. Mendoza is working to identify and characterize the transporters responsible for the long-distance movement in plants of heavy metals, both the essential and the toxic. Understanding these mechanisms will help to enhance the nutritional value and safety of plant based products. This knowledge could also be useful for improving current techniques for phytoremediation, which is the use of plants to clean up toxic compounds, particularly at sites contaminated with heavy metals.

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News about David G. Mendoza-Cózatl

Research Topics

Draft Genome Sequence of the Putative Endophytic Bacterium Pantoea agglomerans R6, Associated with Lactuca serriola from South Africa. Istain B, Mokgokong PS, Wu R, Mia J, Gokul A, Mendoza-Cozatl D, Plessis MD, Keyster M. Microbiology Resource Announcements; 10(10):e00023-21.

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Exogenous 3,3′-diindolylmethane improves vanadium stress tolerance in brassica napus seedling shoots by modulating antioxidant enzyme activities. Gokul A, Fahiem Carelse M, Niekerk L-A, Klein A, Ludidi N, Mendoza-Cozatl D, Keyster M. Biomolecules; 11(3):1-18.

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Cross species multi-omics reveals cell wall sequestration and elevated global transcript abundance as mechanisms of boron tolerance in plants. Wang G, DiTusa SF, Oh D-H, Herrmann AD, Mendoza-Cozatl DG, O'Neill MA, Smith AP, Dassanayake M. New Phytologist; 230:1985-2000.

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Current status of the multinational Arabidopsis community. Parry G, Provart NJ, Brady SM, Uzilday B, Adams K, Araújo W, Aubourg S, Baginsky S, Bakker E, Bärenfaller K, Batley J, Beale M, Beilstein M, Belkhadir Y, Mendel G, Berardini T, Bergelson J, Blanco-Herrera F, Brady S, Braun H-P, Briggs S, Brownfield L, Cardarelli M, Castellanos-Uribe M, Coruzzi G, Dassanayake M, De Jaeger G, Dilkes B, Doherty C, Ecker J, Edger P, Edwards D, El Kasmi F, Eriksson M, Exposito-Alonso M, Falter-Braun P, Fernie A, Ferro M, Fiehn O, Friesner J, Greenham K, Guo Y, Hamann T, Hancock A, Hauser M-T, Heazlewood J, Ho C-H, Hõrak H, Huala E, Hwang I, Iuchi S, Jaiswal P, Jakobson L, Jiang Y, Jiao Y, Jones A, Kadota Y, Khurana J, Kliebenstein D, Knee E, Kobayashi M, Koch M, Krouk G, Larson T, Last R, Lepiniec L, Li S, Lurin C, Lysak M, Maere S, Malinowski R, Maumus F, May S, Mayer K, Mendoza-Cozatl D, Mendoza-Poudereux I, Micol JL, Millar H, Mock H-P, Mukhtar K, Mukhtar S, Murcha M, Nakagami H, Nakamura Y, Nicolov L, Nikolau B, Nowack M, Nunes-Nesi A, Palmgren M, Parry G, Patron N, Peck S, Pedmale U, Perrot-Rechenmann C, Pieruschka R, Pío-Beltrán J, Pires JC, Provart N, Rajjou L, Reiser L, Rhee S, Rigas S, Rolland N, Romanowski A, Savaldi-Goldstein S, Schmitz R, Schulze W, Seki M, Shimizu KK, Slotkin K, Small I, Somers D, Sozzani R, Spillane C, Srinivasan R, Taylor N, Tello-Ruiz M-K, Thelen J, Tohge T, Town C, Toyoda T, Uzilday B, Walley J, Ware D, Weckwerth W, Whitelegge J, Wienkoop S, Wright C, Wrzaczek M, Yamazaki M, Yanovsky M, Žárský V, Zhong X, Van De Peer Y, Van Wijk K, Von Gillhaussen P, The Multinational Arabidopsis Steering Committee. Plant Direct; 4(7):e00248.

Featured in this article: David Mendoza-Cózatl, Scott Peck, J. Chris Pires, Jay Thelen.

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Mapping the metal-catalytic site of a zinc-activated phytochelatin synthase. García-García JD, Sánchez-Thomas R, Saavedra E, Fernández-Velasco DA, Romero-Romero S, Casanova-Figueroa KI, Mendoza-Cózatl DG, Moreno-Sánchez R. Algal Research; 47:101890.

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Expression of a dominant-negative AtNEET-H89C protein disrupts iron–sulfur metabolism and iron homeostasis in Arabidopsis. Zandalinas SI, Song L, Sengupta S, McInturf SA, Grant DG, Marjault H-B, Castro-Guerrero NA, Burks D, Azad RK, Mendoza-Cozatl DG, Nechushtai R, Mittler R. Plant Journal; 101(5):1152-169.

Featured in this article: Norma Castro-Guerrero, David Mendoza-Cózatl, Ron Mittler.

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Keep talking: Crosstalk between iron and sulfur networks fine-tunes growth and development to promote survival under iron limitation. Mendoza-Cózatl DG, Gokul A, Carelse MF, Jobe TO, Long TA, Keyster M. Journal of Experimental Botany; 70(16):4197-4210.

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Copper uptake mechanism of Arabidopsis thaliana high-affinity COPT transporters. Sanz A, Pike S, Khan MA, Carrió-Seguí À, Mendoza-Cózatl DG, Peñarrubia L, Gassmann W. Protoplasma; 256(1):161-170.

Featured in this article: Sharon Pike, David Mendoza-Cózatl, Walter Gassmann.

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Zinc uptake in the Basidiomycota: Characterization of zinc transporters in Ustilago maydis. Martha-Paz AM, Eide D, Mendoza-Cózatl D, Castro-Guerrero NA, Aréchiga-Carvajal ET. Molecular Membrane Biology; 35(1):39-50.

Featured in this article: David Mendoza-Cózatl, Norma Castro-Guerrero.

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Phosphate deficiency negatively affects early steps of the symbiosis between common bean and Rhizobia. Isidra-Arellano MC, Reyero-Saavedra MR, Sánchez-Correa MS, Pingault L, Sen S, Joshi T, Girard L, Castro-Guerrero NA, Mendoza-Cozatl DG, Libault M, Valdés-López O. Genes; 9(10):498.

Featured in this article: Sidharth Sen, Trupti Joshi, Norma Castro-Guerrero, David Mendoza-Cózatl.

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Changes in iron availability in Arabidopsis are rapidly sensed in the leaf vasculature and impaired sensing leads to opposite transcriptional programs in leaves and roots. Khan MA, Castro-Guerrero NA, McInturf SA, Nguyen NT, Dame AN, Wang J, Bindbeutel RK, Joshi T, Jurisson SS, Nusinow DA, Mendoza-Cozatl DG. Plant Cell and Enviroment; 41(10):2263-2276.

Featured in this article: Norma Castro-Guerrero, Trupti Joshi, David Mendoza-Cózatl.

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Quantitative proteomics analysis of leaves from two Sedum alfredii (Crassulaceae) populations that differ in cadmium accumulation. Zhang Z, Zhou H, Yu Q, Li Y, Mendoza-Cózatl DG, Qiu B, Liu P, Chen Q. Proteomics; 17(10):1600456.

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Moderate to severe water limitation differentially affects the phenome and ionome of Arabidopsis. Acosta-Gamboa LM, Liu S, Langley E, Campbell Z, Castro-Guerrero N, Mendoza-Cozatl D, Lorence A. Functional Plant Biology; 44(1):94-106.

Featured in this article: Norma Castro-Guerrero, David Mendoza-Cózatl.

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Hydroponics: A versatile system to study nutrient allocation and plant responses to nutrient availability and exposure to toxic elements. Nguyen NT, McInturf SA, Mendoza-Cózatl DG. Journal of Visualized Experiments; 2016(113):e54317.

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Enhanced cadmium efflux and root-to-shoot translocation are conserved in the hyperaccumulator Sedum alfredii (Crassulaceae family). Zhang Z, Yu Q, Du H, Ai W, Yao X, Mendoza-Cózatl DG, Qiu B. FEBS Letters; 1757-1764.

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Common bean: A legume model on the rise for unraveling responses and adaptations to iron, zinc, and phosphate deficiencies. Castro-Guerrero NA, Isidra-Arellano MC, Mendoza-Cozat DG, Valdés-López O. Frontiers in Plant Science; 7(May 2016):600.

Featured in this article: Norma Castro-Guerrero, David Mendoza-Cózatl.

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Identification of AtOPT4 as a Plant Glutathione Transporter. Zhang Z, Xie Q, Jobe TO, Kau AR, Wang C, Li Y, Qiu B, Wang Q, Mendoza-Cózatl DG, Schroeder JI. Molecular Plant; 9(3):481-484.

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OPT3 is a component of the iron-signaling network between leaves and roots and misregulation of OPT3 leads to an over-accumulation of cadmium in seeds. Mendoza-Cózatl DG, Xie Q, Akmakjian GZ, Jobe TO, Patel A, Stacey MG, Song L, Demoin DW, Jurisson SS, Stacey G, Schroeder JI. Molecular Plant; 7(9):1455-1469.

Featured in this article: David Mendoza-Cózatl, Minviluz (Bing) Stacey, Gary Stacey.

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Phytochelatin-metal(loid) transport into vacuoles shows different substrate preferences in barley and Arabidopsis. Song W-Y, Mendoza-Cózatl DG, Lee Y, Schroeder JI, Ahn S-N, Lee H-S, Wicker T, Martinoia E. Plant, Cell and Environment; 37(5):1192-1201.

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Zn-bis-glutathionate is the best co-substrate of the monomeric phytochelatin synthase from the photosynthetic heavy metal-hyperaccumulator Euglena gracilis. García-García JD, Girard L, Hernández G, Saavedra E, Pardo JP, Rodríguez-Zavala JS, Encalada R, Reyes-Prieto A, Mendoza-Cózatl DG, Moreno-Sánchez R. Metallomics; 6(3):604-616.

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Moving toward a precise nutrition: Preferential loading of seeds with essential nutrients over non-essential toxic elements. Khan MA, Castro-Guerrero N, Mendoza-Cozatl DG. Frontiers in Plant Science; 5(FEB):51.

Featured in this article: Norma Castro-Guerrero, David Mendoza-Cózatl.

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Elemental Concentrations in the Seed of Mutants and Natural Variants of Arabidopsis thaliana Grown under Varying Soil Conditions. McDowell SC, Akmakjian G, Sladek C, Mendoza-Cozatl D, Morrissey JB, Saini N, Mittler R, Baxter I, Salt DE, Ward JM, Schroeder JI, Guerinot ML, Harper JF. PLoS ONE; 8(5):e63014.

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Feedback inhibition by thiols outranks glutathione depletion: A luciferase-based screen reveals glutathione-deficient γ-ECS and glutathione synthetase mutants impaired in cadmium-induced sulfate assimilation. Jobe TO, Sung D-Y, Akmakjian G, Pham A, Komives EA, Mendoza-Cózatl DG, Schroeder JI. Plant Journal; 70(5):783-795.

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Long-distance transport, vacuolar sequestration, tolerance, and transcriptional responses induced by cadmium and arsenic. Mendoza-Cózatl DG, Jobe TO, Hauser F, Schroeder JI. Current Opinion in Plant Biology; 14(5):554-562.

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Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance. Mendoza-Cózatl DG, Zhai Z, Jobe TO, Akmakjian GZ, Song W-Y, Limbo O, Russell MR, Kozlovskyy VI, Martinoia E, Vatamaniuk OK, Russell P, Schroeder JI. Journal of Biological Chemistry; 285(52):40416-40426.

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Arsenic tolerance in Arabidopsis is mediated by two ABCC-type phytochelatin transporters. Song W-Y, Park J, Mendoza-Cózatl DG, Suter-Grotemeyer M, Shima D, Hörtensteiner S, Geisler M, Weder B, Rea PA, Rentsch D, Schroeder JI, Lee Y, Martinoia E. Proceedings of the National Academy of Sciences of the United States of America; 107(49):21187-21192.

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ARS5 is a component of the 26S proteasome complex, and negatively regulates thiol biosynthesis and arsenic tolerance in Arabidopsis. Sung D-Y, Kim T-H, Komives EA, Mendoza-Cózatl DG, Schroeder JI. Plant Journal; 59(5):802-813.

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Chromium uptake, retention and reduction in photosynthetic Euglena gracilis. García-García JD, Rodríguez-Zavala JS, Jasso-Chávez R, Mendoza-Cozatl D, Moreno-Sánchez R. Archives of Microbiology; 191(5):431-440.

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The Pb-hyperaccumulator aquatic fern Salvinia minima Baker, responds to Pb2+ by increasing phytochelatins via changes in SmPCS expression and in phytochelatin synthase activity. Estrella-Gómez N, Mendoza-Cózatl D, Moreno-Sánchez R, González-Mendoza D, Zapata-Pérez O, Martínez-Hernández A, Santamaría JM. Aquatic Toxicology; 91(4):320-328.

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Identification of high levels of phytochelatins, glutathione and cadmium in the phloem sap of Brassica napus. A role for thiol-peptides in the long-distance transport of cadmium and the effect of cadmium on iron translocation. Mendoza-Cózatl DG, Butko E, Springer F, Torpey JW, Komives EA, Kehr J, Schroeder JI. Plant Journal; 54(2):249-259.

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Thiol peptides induction in the seagrass Thalassia testudinum (Banks ex König) in response to cadmium exposure. Alvarez-Legorreta T, Mendoza-Cozatl D, Moreno-Sanchez R, Gold-Bouchot G. Aquatic Toxicology; 86(1):12-19.

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Cell wall composition affects Cd2+ accumulation and intracellular thiol peptides in marine red algae. García-Ríos V, Freile-Pelegrín Y, Robledo D, Mendoza-Cózatl D, Moreno-Sánchez R, Gold-Bouchot G. Aquatic Toxicology; 81(1):65-72.

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Phytochelatin-cadmium-sulfide high-molecular-mass complexes of Euglena gracilis. Mendoza-Cózatl DG, Rodríguez-Zavala JS, Rodríguez-Enríquez S, Mendoza-Hernandez G, Briones-Gallardo R, Moreno-Sánchez R. FEBS Journal; 273(24):5703-5713.

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Simultaneous Cd2+, Zn2+, and Pb2+ uptake and accumulation by photosynthetic Euglena gracilis. Mendoza-Cózatl DG, Rangel-González E, Moreno-Sánchez R. Archives of Environmental Contamination and Toxicology; 51(4):521-528.

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Control of glutathione and phytochelatin synthesis under cadmium stress. Pathway modeling for plants. Mendoza-Cózatl DG, Moreno-Sánchez R. Journal of Theoretical Biology; 238(4):919-936.

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Time-course development of the Cd2+ hyper-accumulating phenotype in Euglena gracilis. Avilés C, Torres-Márquez ME, Mendoza-Cózatl D, Moreno-Sánchez R. Archives of Microbiology; 184(2):83-92.

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The bacterial-like lactate shuttle components from heterotrophic Euglena gracilis. Jasso-Chávez R, García-Cano I, Marín-Hernández A, Mendoza-Cózatl D, Rendón JL, Moreno-Sánchez R. Biochimica et Biophysica Acta - Bioenergetics; 1709(2):181-190.

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Sulfur assimilation and glutathione metabolism under cadmium stress in yeast, protists and plants. Mendoza-Cózatl D, Loza-Tavera H, Hernández-Navarro A, Moreno-Sánchez R. FEMS Microbiology Reviews; 29(4):653-671.

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Cd 2+ transport and storage in the chloroplast of Euglena gracilis. Mendoza-Cózatl DG, Moreno-Sánchez R. Biochimica et Biophysica Acta - Bioenergetics; 1706(1-2):88-97.

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Cadmium accumulation in the chloroplast of Euglena gracilis. Mendoza-Cozatl D, Devars S, Loza-Tavera H, Moreno-Sánchez R. Physiologia Plantarum; 115(2):276-283.

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