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D Cornelison

D Cornelison

Professor, Biological Sciences

Phone: 573-882-9690
cornelisond@missouri.edu
340f Bond Life Sciences Center

Dawn Cornelison is a professor in biological sciences. Work in Cornelison’s lab is aimed at understanding satellite cells, the stem cells responsible for growth, repair, and regeneration of skeletal muscle. In particular, the lab studies how satellite cells get information from the local environment, then use that information to decide whether to divide, move to another area in the muscle, or differentiate into functional muscle cells. This research is important not only for the insight it will provide into how the body maintains and repairs itself over a lifetime’s worth of wear and tear, but also because it may help to develop new treatments and therapies for muscle loss due to aging or degenerative diseases such as Duchenne’s muscular dystrophy.

Lab site: Cornelison Lab

News about D Cornelison

Research Topics

Epha7 promotes myogenic differentiation via cell-cell contact. Arnold LL, Cecchini A, Stark DA, Ihnat J, Craigg RN, Carter A, Zino S, Cornelison DDW. eLife; 9:e53689.

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Barium chloride injures myofibers through calcium-induced proteolysis with fragmentation of motor nerves and microvessels. Morton AB, Norton CE, Jacobsen NL, Fernando CA, Cornelison DDW, Segal SS. Skeletal Muscle; 9(1):27.

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Science at Sundance. Krauss RS, Shapiro MD, Koch PL, Kardon G, Cornelison DDW. Science; 363(6433):1270.

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Recovery of blood flow regulation in microvascular resistance networks during regeneration of mouse gluteus maximus muscle. Fernando CA, Pangan AM, Cornelison DDW, Segal SS. Journal of Physiology; 597(5):1401-1417.

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“Known Unknowns”: Current Questions in Muscle Satellite Cell Biology. Cornelison DDW. Current Topics in Developmental Biology; 126:205-233.

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Muscle spindle alterations precede onset of sensorimotor deficits in Charcot–Marie–Tooth type 2E. Villalón E, Jones MR, Sibigtroth C, Zino SJ, Dale JM, Landayan DS, Shen H, Cornelison DDW, Garcia ML. Genes, Brain and Behavior; 16(2):260-270.

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Muscle stem cells: A model system for adult stem cell biology. Cornelison DDW, Perdiguero E. Methods in Molecular Biology; 1556:3-19.

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Methods for observing and quantifying muscle satellite cell motility and invasion in vitro. Lund DK, McAnulty P, Siegel AL, Cornelison D. Methods in Molecular Biology; 1556:303-315.

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An NF-κB – EphrinA5-Dependent Communication between NG2+ Interstitial Cells and Myoblasts Promotes Muscle Growth in Neonates. Gu J-M, Wang DJ, Peterson JM, Shintaku J, Liyanarachchi S, Coppola V, Frakes AE, Kaspar BK, Cornelison DD, Guttridge DC. Developmental Cell; 36(2):215-224.

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Neural activation patterns underlying basolateral amygdala influence on intra-accumbens opioid-driven consummatory versus appetitive high-fat feeding behaviors in the rat. Parker KE, McCabe MP, Johns HW, Lund DK, Odu F, Sharma R, Thakkar MM, Cornelison DDW, Will MJ. Behavioral Neuroscience; 129(6):812-821.

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NEDD4 Regulates PAX7 Levels Promoting Activation of the Differentiation Program in Skeletal Muscle Precursors. Bustos F, De La Vega E, Cabezas F, Thompson J, Cornelison DDW, Olwin BB, Yates JR, Olguín HC. Stem Cells; 33(10):3138-3151.

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Ephrin-A3 promotes and maintains slow muscle fiber identity during postnatal development and reinnervation. Stark DA, Coffey NJ, Pancoast HR, Arnold LL, Walker JPD, Vallée J, Robitaille R, Garcia ML, Cornelison DDW. Journal of Cell Biology; 211(5):1077-1091.

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MMP-14 is necessary but not sufficient for invasion of three-dimensional collagen by human muscle satellite cells. Lund DK, Mouly V, Cornelison DDW. American Journal of Physiology - Cell Physiology; 307(2):C140-C149.

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Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength. Bentzinger CF, von Maltzahn J, Dumont NA, Stark DA, Wang YX, Nhan K, Frenette J, Cornelison DDW, Rudnicki MA. Journal of Cell Biology; 205(1):97-111.

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Rhabdomyosarcoma: Current challenges and their implications for developing therapies. Hettmer S, Li Z, Billin AN, Barr FG, Cornelison D, Ehrlich AR, Guttridge DC, Hayes-Jordan A, Helman LJ, Houghton PJ, Khan J, Langenau DM, Linardic CM, Pal R, Partridge TA, Pavlath GK, Rota R, Schafer BW, Shipley J, Stillman B, Wexler LH, Wagers AJ, Keller C. Cold Spring Harbor Perspectives in Medicine; 4(11):1-8.

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Enter the matrix: Shape, signal and superhighway. Lund DK, Cornelison DDW. FEBS Journal; 280(17):4089-4099.

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Semi-automated tracking of muscle satellite cells in brightfield microscopy video. Chowdhury AS, Paul A, Bunyak F, Cornelison DDW, Palaniappan K. 2012 19th IEEE International Conference on Image Processing; 2012:2825-2828.

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A role for RNA post-transcriptional regulation in satellite cell activation. Farina NH, Hausburg M, Betta ND, Pulliam C, Srivastava D, Cornelison DDW, Olwin BB. Skeletal Muscle; 2(1):21.

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Eph/ephrin interactions modulate muscle satellite cell motility and patterning. Stark DA, Karvas RM, Siege AL, Cornelison DDW. Development; 138(24):5279-5289.

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CD34 promotes satellite cell motility and entry into proliferation to facilitate efficient skeletal muscle regeneration. Alfaro LAS, Dick SA, Siegel AL, Anonuevo AS, McNagny KM, Megeney LA, Cornelison DDW, Rossi FMV. Stem Cells; 29(12):2030-2041.

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Muscle satellite cells from GRMD dystrophic dogs are not phenotypically distinguishable from wild type satellite cells in ex vivo culture. Berg Z, Beffa LR, Cook DP, Cornelison DDW. Neuromuscular Disorders; 21(4):282-290.

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Muscle satellite cell proliferation and association: new insights from myofiber time-lapse imaging. Siegel AL, Kuhlmann PK, Cornelison DDW. Skeletal Muscle; 1(1):7.

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Syndecan-3 and Notch cooperate in regulating adult myogenesis. Pisconti A, Cornelison DDW, Olguín HC, Antwine TL, Olwin BB. Journal of Cell Biology; 190(3):427-441.

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3D timelapse analysis of muscle satellite cell motility. Siegel A, Atchison K, Fisher KE, Davis GE, Cornelison DDW. Stem Cells; 27(10):2527-2538.

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Syndecan-4-Expressing Muscle Progenitor Cells in the SP Engraft as Satellite Cells during Muscle Regeneration. Tanaka KK, Hall JK, Troy AA, Cornelison DDW, Majka SM, Olwin BB. Cell Stem Cell; 4(3):217-225.

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Context matters: In vivo and in vitro influences on muscle satellite cell activity. Cornelison DDW. Journal of Cellular Biochemistry; 105(3):663-669.

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Neural cell adhesion molecule (NCAM) marks adult myogenic cells committed to differentiation. Capkovic KL, Stevenson S, Johnson MC, Thelen JJ, Cornelison DDW. Experimental Cell Research; 314(7):1553-1564.

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The p38α/β MAPK functions as a molecular switch to activate the quiescent satellite cell. Jones NC, Tyner KJ, Nibarger L, Stanley HM, Cornelison DDW, Fedorov YV, Olwin BB. Journal of Cell Biology; 169(1):105-116.

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Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration. Cornelison DDW, Wilcox-Adelman SA, Goetinck PF, Rauvala H, Rapraeger AC, Olwin BB. Genes and Development; 18(18):2231-2236.

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Chapter 5 Role of cytokines in skeletal muscle growth and differentiation. Olwin BB, Bren-Mattison Y, Cornelison DDW, Fedorov YV, Flanagan-Steet H, Jones NC. Advances in Developmental Biology and Biochemistry; 11(C):97-126.

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Syndecan-3 and syndecan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regeneration. Cornelison DDW, Filla MS, Stanley HM, Rapraeger AC, Olwin BB. Developmental Biology; 239(1):79-94.

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MyoD(-/-) satellite cells in single-fiber culture are differentiation defective and MRF4 deficient. Cornelison DDW, Olwin BB, Rudnicki MA, Wold BJ. Developmental Biology; 224(2):122-137.

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Single-cell analysis of regulatory gene expression in quiescent and activated mouse skeletal muscle satellite cells. Cornelison DDW, Wold BJ. Developmental Biology; 191(2):270-283.

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