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Marc Johnson

Marc Johnson

Professor, Molecular Microbiology and Immunology

Phone: 573-882-1519
marcjohnson@missouri.edu
471c Bond Life Sciences Center

Marc Johnson is an associate professor of molecular microbiology and immunology (MMI). The Johnson lab studies the interactions that occur between viruses (particularly HIV) and their hosts. Viruses are obligate intracellular parasites, meaning that they are completely unable replicate without the help of their host organism. They accomplish this by tricking cellular machinery into producing and assembling all of the pieces needed to make more virus. How this coercion is accomplished is often poorly understood. Often the normal role of host genes is only understood after we uncover how the virus subvert them. The Johnson lab in particular studies how viruses use host machinery to transport all of the viral pieces to correct location in the cell for assembly. A clearer understanding of these interactions will provide new avenues for the development of antiviral drugs.

News about Marc Johnson

Research Topics

RNA-protein interactions govern antiviral specificity and encapsidation of broad spectrum anti-HIV reverse transcriptase aptamers. Lange MJ, Nguyen PDM, Callaway MK, Johnson MC, Burke DH. Nucleic Acids Research; 45(10):6087-6097.

Featured in this article: Margaret Lange, Marc Johnson, Donald Burke-Agüero.

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In vivo analysis of infectivity, fusogenicity, and incorporation of a mutagenic viral glycoprotein library reveals determinants for virus incorporation. Salamango DJ, Alam KK, Burke DH, Johnson MC. Journal of Virology; 90(14):6502-6514.

Featured in this article: Donald Burke-Agüero, Marc Johnson.

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Robust suppression of HIV replication by intracellularly expressed reverse transcriptase aptamers is independent of ribozyme processing. Lange MJ, Sharma TK, Whatley AS, Landon LA, Tempesta MA, Johnson MC, Burke DH. Molecular Therapy; 20(12):2304-2314.

Featured in this article: Margaret Lange, Marc Johnson, Donald Burke-Agüero.

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Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase. Ndongwe TP, Adedeji AO, Michailidis E, Ong YT, Hachiya A, Marchand B, Ryan EM, Rai DK, Kirby KA, Whatley AS, Burke DH, Johnson M, Ding S, Zheng Y-M, Liu S-L, Kodama E-I, Delviks-Frankenberry KA, Pathak VK, Mitsuya H, Parniak MA, Singh K, Sarafianos SG. Nucleic Acids Research; 40(1):345-359.

Featured in this article: Donald Burke-Agüero, Marc Johnson, Kamlendra Singh.

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