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Lloyd Sumner

Lloyd Sumner

Professor, Biochemistry; Director, Metabolomics Center

Phone: 573-882-5486
sumnerlw@missouri.edu
240d MU Bond Life Sciences Center

The research focus of the Sumner lab includes the development of cutting-edge technologies for large-scale biochemical profiling of plant metabolites (ie metabolomics) and integrating these with transcriptomics. These technologies are then applied in a symbiotic manner for plant gene discovery, gene characterization and the elucidation of mechanistic responses to external stimuli; especially related to plant specialized metabolism or plant natural products biosynthesis. Technology enables the biology and the biology drives technology development. Current technology development projects include the development of a sophisticated and integrated ensemble including UHPLC-MS-SPE-NMR for the systematic and biologically driven annotation of plant metabolomes. This suite of tools is being applied to better understand carbon sequestration in cell wall lignin and lipids. The Sumner lab is also currently using integrated metabolomics for the discovery and characterization of triterpene saponin biosynthetic genes in the model legume Medicago truncatula. We have proven success in using this technology for a better understanding of natural products including flavonoids, isoflavonoids, terpenoids, and waxes.

The Sumner lab has a long and proven history of productive collaboration and has recently relocated to the University of Missouri where they are establishing a new University of Missouri Metabolomics Center (UMMC) to further enhance and enable additional collaborations. The UMMC will also provide regular training courses and continual educational opportunities for collaborators. Although Dr. Sumner spent most of the past 16 years at private, non-degree granting research institute, the Sumner lab has hosted approximately 20 undergraduate researchers over the years and welcomes the opportunity for more. The Sumner lab has also hosted approximate 15, one-week long, hands-on annual workshops that provided in-depth metabolomics and proteomics training for approximately 300 graduate students, postdocs, professional staff and faculty.

The Sumner lab is an internationally recognized leader in plant metabolomics, plant proteomics, and plant natural product biochemistry. Dr. Sumner has served as the President and Treasurer of the Metabolomics Society. Dr. Sumner is also the Principal Investigator of a recent Plant, Algae, and Microbial Research Coordination network initiative and he is the current President of the Phytochemical Society of America.

News about Lloyd Sumner

2021

A medicago truncatula metabolite atlas enables the visualization of differential accumulation of metabolites in root tissues. Kranawetter C, Zeng S, Joshi T, Sumner LW. Metabolites; 11(4):238.

Date published: April 1, 2021
Featured in this article: Clayton Kranawetter, Shuai Zeng, Trupti Joshi, Lloyd Sumner.

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2020

Developmental exposure of California mice to endocrine disrupting chemicals and potential effects on the microbiome-gut-brain axis at adulthood. Kaur S, Sarma SJ, Marshall BL, Liu Y, Kinkade JA, Bellamy MM, Mao J, Helferich WG, Schenk AK, Bivens NJ, Lei Z, Sumner LW, Bowden JA, Koelmel JP, Joshi T, Rosenfeld CS. Scientific Reports; 10(1):10902.

Date published: December 1, 2020
Featured in this article: Saurav Sarma, Jessica Kinkade, Jiude Mao, Nathan Bivens, Zhentian Lei, Lloyd Sumner, Trupti Joshi.

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Author Correction: Developmental exposure of California mice to endocrine disrupting chemicals and potential effects on the microbiome-gut-brain axis at adulthood (Scientific Reports, (2020), 10, 1, (10902), 10.1038/s41598-020-67709-9). Kaur S, Sarma SJ, Marshall BL, Liu Y, Kinkade JA, Bellamy MM, Mao J, Helferich WG, Schenk AK, Bivens NJ, Lei Z, Sumner LW, Bowden JA, Koelmel JP, Joshi T, Rosenfeld CS. Scientific Reports; 10(1):12524.

Date published: December 1, 2020
Featured in this article: Saurav Sarma, Jessica Kinkade, Jiude Mao, Nathan Bivens, Zhentian Lei, Lloyd Sumner, Trupti Joshi.

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Proteomic and Metabolomic Analysis of Azospirillum brasilense ntrC Mutant under High and Low Nitrogen Conditions. Kukolj C, Pedrosa FO, De Souza GA, Sumner LW, Lei Z, Sumner B, Do Amaral FP, Juexin W, Trupti J, Huergo LF, Monteiro RA, Valdameri G, Stacey G, De Souza EM. Journal of Proteome Research; 19(1):92-105.

Date published: January 3, 2020
Featured in this article: Lloyd Sumner, Zhentian Lei, Barbara Sumner, Juexin Wang, Trupti Joshi, Gary Stacey.

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2019

12-Hydroxy-Jasmonoyl-l-Isoleucine Is an Active Jasmonate That Signals through CORONATINE INSENSITIVE 1 and Contributes to the Wound Response in Arabidopsis. Poudel AN, Holtsclaw RE, Kimberlin A, Sen S, Zeng S, Joshi T, Lei Z, Sumner LW, Singh K, Matsuura H, Koo AJ. Plant and Cell Physiology; 60(10):2152-2166.

Date published: October 1, 2019
Featured in this article: Sidharth Sen, Shuai Zeng, Trupti Joshi, Zhentian Lei, Lloyd Sumner, Kamlendra Singh.

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Early genistein exposure of California mice and effects on the gut microbiota-brain axis. Marshall BL, Liu Y, Farrington MJ, Mao J, Helferich WG, Schenk AK, Bivens NJ, Sarma SJ, Lei Z, Sumner LW, Joshi T, Rosenfeld CS. Journal of Endocrinology; 242(2):139-157.

Date published: August 1, 2019
Featured in this article: Jiude Mao, Nathan Bivens, Saurav Sarma, Zhentian Lei, Lloyd Sumner, Trupti Joshi.

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2010

Soybean metabolites regulated in root hairs in response to the symbiotic bacterium Bradyrhizobium japonicum. Brechenmacher L, Lei Z, Libault M, Findley S, Sugawara M, Sadowsky MJ, Sumner LW, Stacey G. Plant Physiology; 153(4):1808-1822.

Date published: August 1, 2010
Featured in this article: Zhentian Lei, Lloyd Sumner, Gary Stacey.

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2003

Profiling phenolic metabolites in transgenic alfalfa modified in lignin biosynthesis. Chen F, Duran AL, Blount JW, Sumner LW, Dixon RA. Phytochemistry; 64(5):1013-1021.

Date published: November 1, 2003
Featured in this article: Lloyd Sumner.

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Plant metabolomics: Large-scale phytochemistry in the functional genomics era. Sumner LW, Mendes P, Dixon RA. Phytochemistry; 62(6):817-836.

Date published: March 1, 2003
Featured in this article: Lloyd Sumner.

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Mapping the proteome of barrel medic (Medicago truncatula). Watson BS, Asirvatham VS, Wang L, Sumner LW. Plant Physiology; 131(3):1104-1123.

Date published: March 1, 2003
Featured in this article: Lloyd Sumner.

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2002

Analytical and biological variances associated with proteomic studies of Medicago truncatula by two-dimensional polyacrylamide gel electrophoresis. Asirvatham VS, Watson BS, Sumner LW. Proteomics; 2(8):960-968.

Date published: August 1, 2002
Featured in this article: Lloyd Sumner.

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Protein identification success rates using peptide mass fingerprints to search protein and nucleotide databases in the proteomics studies of Medicago truncatula. Asirvatham VS, Watson BS, Wang L, Sumner LW. Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics; 201-202.

Date published: June 2, 2002
Featured in this article: Lloyd Sumner.

Metabolome profiling of Medicago truncatula yields insight info biological variance and development. Duran AL, Broeckling CD, Huhman DV, Sumner LW. Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics; 475-476.

Date published: June 2, 2002
Featured in this article: Lloyd Sumner.

Ion-neutral ratios: A unique measure of internal energy content of MALDI ions. Liu Z, Russell DH, Sumner LW. Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics; 785-786.

Date published: June 2, 2002
Featured in this article: Lloyd Sumner.

Metabolic profiling of saponins in Medicago sativa and Medicago truncatula using HPLC coupled to an electrospray ion-trap mass spectrometer. Huhman DV, Sumner LW. Phytochemistry; 59(3):347-360.

Date published: February 20, 2002
Featured in this article: Lloyd Sumner.

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Plant metabolomics: The missing link in functional genomics strategies. Hall R, Beale M, Fiehn O, Hardy N, Sumner L, Bino R. Plant Cell; 14(7):1437-1440.

Date published: January 1, 2002
Featured in this article: Lloyd Sumner.

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Silver stain removal using H2O2 for enhanced peptide mass mapping by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Sumner LW, Wolf-Sumner B, White SP, Asirvatham VS. Rapid Communications in Mass Spectrometry; 16(3):160-168.

Date published: January 1, 2002
Featured in this article: Lloyd Sumner, Barbara Sumner.

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Over-expression of cinnamate 4-hydroxylase leads to increased accumulation of acetosyringone in elicited tobacco cell-suspension cultures. Blount JW, Masoud S, Sumner LW, Huhman D, Dixon RA. Planta; 214(6):902-910.

Date published: January 1, 2002
Featured in this article: Lloyd Sumner.

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Chapter Three Metabolomics: A developing and integral component in functional genomic studies of medicago truncatula. Sumner LW, Duran AL, Huhman DV, Smith JT. Recent Advances in Phytochemistry; 36(C):31-61.

Date published: January 1, 2002
Featured in this article: Lloyd Sumner.

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1998

Definition of the redox states of cobalt-precorrinoids: Investigation of the substrate and redox specificity of CbiL from Salmonella typhimurium. Spancer P, Stolowich NJ, Sumner LW, Scott AI. Biochemistry; 37(42):14917-14927.

Date published: October 20, 1998
Featured in this article: Lloyd Sumner.

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Characterization of proteins utilized in the desulfurization of petroleum products by matrix-assisted laser desorption ionization time-of- flight mass spectrometry. Wolf BP, Sumner LW, Shields SJ, Neilsen K, Gray KA, Russell DH. Analytical Biochemistry; 260(2):117-127.

Date published: July 1, 1998
Featured in this article: Lloyd Sumner.

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Pentacoordinate (μ-Oxo)diiron (III) Thiolate Complexes and Dimeric Iron(II) Precursors. Musie G, Lai C-h, Reibenspies JH, Sumner LW, Darensbourg MY. Inorganic Chemistry; 37(16):4086-4093.

Date published: January 1, 1998
Featured in this article: Lloyd Sumner.

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1996

High-performance liquid chromatography/continuous-flow liquid secondary ion mass spectrometry of flavonoid glycosides in leguminous plant extracts. Sumner LW, Paiva NL, Dixon RA, Geno PW. Journal of Mass Spectrometry; 31(5):472-485.

Date published: May 1, 1996
Featured in this article: Lloyd Sumner.

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Template effect for O ₂ addition across cis-sulfur sites in nickel dithiolates. Grapperhaus CA, Darensbourg MY, Sumner LW, Russell DH. Journal of the American Chemical Society; 118(7):1791-1792.

Date published: February 21, 1996
Featured in this article: Lloyd Sumner.

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1993

Determination of cinnamic acid and 4‐coumaric acid in alfalfa (Medicago sativa L.) cell suspension cultures by gas chromatography. Orr JD, Sumner LW, Edwards R, Dixon RA. Phytochemical Analysis; 4(3):124-130.

Date published: May 1, 1993
Featured in this article: Lloyd Sumner.

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A novel mobile phase for continuous‐flow liquid secondary ion mass spectrometry of high molecular mass phthalocyanines. Sumner LW, Ford WT, Chang YH, Choi KH, Lee JJ. Organic Mass Spectrometry; 28(4):475-477.

Date published: April 1, 1993
Featured in this article: Lloyd Sumner.

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1992

Citrate is a major component of snake venoms. Freitas MA, Geno PW, Sumner LW, Cooke ME, Hudiburg SA, Ownby CL, Kaiser II, Odell GV. Toxicon; 30(4):461-464.

Date published: April 1, 1992
Featured in this article: Lloyd Sumner.

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