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Zhentian Lei

Zhentian Lei

Assistant Director Metabolomics Center, Assistant Research Professor of Biochemistry

Phone: (573) 884-3345
leiz@missouri.edu
240f Christopher S. Bond Life Science Center

News about Zhentian Lei

2020

Developmental exposure of California mice to endocrine disrupting chemicals and potential effects on the microbiome-gut-brain axis at adulthood. Kaur S, Sarma SJ, Marshall BL, Liu Y, Kinkade JA, Bellamy MM, Mao J, Helferich WG, Schenk AK, Bivens NJ, Lei Z, Sumner LW, Bowden JA, Koelmel JP, Joshi T, Rosenfeld CS. Scientific Reports; 10(1):10902.

Date published: December 1, 2020
Featured in this article: Saurav Sarma, Jessica Kinkade, Jiude Mao, Nathan Bivens, Zhentian Lei, Lloyd Sumner, Trupti Joshi.

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Author Correction: Developmental exposure of California mice to endocrine disrupting chemicals and potential effects on the microbiome-gut-brain axis at adulthood (Scientific Reports, (2020), 10, 1, (10902), 10.1038/s41598-020-67709-9). Kaur S, Sarma SJ, Marshall BL, Liu Y, Kinkade JA, Bellamy MM, Mao J, Helferich WG, Schenk AK, Bivens NJ, Lei Z, Sumner LW, Bowden JA, Koelmel JP, Joshi T, Rosenfeld CS. Scientific Reports; 10(1):12524.

Date published: December 1, 2020
Featured in this article: Saurav Sarma, Jessica Kinkade, Jiude Mao, Nathan Bivens, Zhentian Lei, Lloyd Sumner, Trupti Joshi.

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Protein Precipitation to Remove Carbohydrates that Interfere in Protein-Bound Tryptophan Quantification in Soybean Seeds. Lei Z, Kumar S, Sarma SJ, Kumar R, Sumner BW, Stacey MG, Sumner LW. Journal of Analysis and Testing; 4(3):238-247.

Date published: July 1, 2020
Featured in this article: Zhentian Lei, Saurav Sarma, Barbara Sumner, Minviluz (Bing) Stacey, Lloyd Sumner.

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Integration of genomics, metagenomics, and metabolomics to identify interplay between susceptibility alleles and microbiota in adenoma initiation. Moskowitz JE, Doran AG, Lei Z, Busi SB, Hart ML, Franklin CL, Sumner LW, Keane TM, Amos-Landgraf JM. BMC Cancer; 20(1):600.

Date published: June 29, 2020
Featured in this article: Zhentian Lei, Lloyd Sumner.

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Identification of health-promoting bioactive phenolics in black walnut using cloud-based metabolomics platform. Vu DC, Park J, Ho K-V, Sumner LW, Lei Z, Greenlief CM, Mooney B, Coggeshall MV, Lin C-H. Journal of Food Measurement and Characterization; 14(2):770-777.

Date published: April 1, 2020
Featured in this article: Lloyd Sumner, Zhentian Lei, Michael Greenlief, Brian Mooney.

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Identification and Quantification of Bioactive Molecules Inhibiting Pro-inflammatory Cytokine Production in Spent Coffee Grounds Using Metabolomics Analyses. Ho K-V, Schreiber KL, Park J, Vo PH, Lei Z, Sumner LW, Brown CR, Lin C-H. Frontiers in Pharmacology; 11:229.

Date published: March 6, 2020
Featured in this article: Zhentian Lei, Lloyd Sumner.

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Bisphenol A and bisphenol S disruptions of the mouse placenta and potential effects on the placenta-brain axis. Mao J, Jain A, Denslow ND, Nouri M-Z, Chen S, Wang T, Zhu N, Koh J, Sarma SJ, Sumner BW, Lei Z, Sumner LW, Bivens NJ, Michael Roberts R, Tuteja G, Rosenfeld CS. Proceedings of the National Academy of Sciences of the United States of America; 117(9):4642-4652.

Date published: March 3, 2020
Featured in this article: Jiude Mao, Saurav Sarma, Barbara Sumner, Zhentian Lei, Lloyd Sumner, Nathan Bivens, Michael Roberts.

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Nontargeted fecal metabolomics: An emerging tool to probe the role of the gut microbiome in host health. Sarma SJ, Lei Z, Rosenfeld CS, Ericsson A, Sumner LW. Bioanalysis; 12(6):351-353.

Date published: March 1, 2020
Featured in this article: Saurav Sarma, Zhentian Lei, Lloyd Sumner.

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Proteomic and Metabolomic Analysis of Azospirillum brasilense ntrC Mutant under High and Low Nitrogen Conditions. Kukolj C, Pedrosa FO, De Souza GA, Sumner LW, Lei Z, Sumner B, Do Amaral FP, Juexin W, Trupti J, Huergo LF, Monteiro RA, Valdameri G, Stacey G, De Souza EM. Journal of Proteome Research; 19(1):92-105.

Date published: January 3, 2020
Featured in this article: Lloyd Sumner, Zhentian Lei, Barbara Sumner, Juexin Wang, Trupti Joshi, Gary Stacey.

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Allelopathic potential of rice and identification of published allelochemicals by cloud-based metabolomics platform. Ho TL, Nguyen TTC, Vu DC, Nguyen NY, Nguyen TTT, Phong TNH, Nguyen CT, Lin C-H, Lei Z, Sumner LW, Le VV. Metabolites; 10(6):1-20.

Date published: January 1, 2020
Featured in this article: Zhentian Lei, Lloyd Sumner.

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2019

12-Hydroxy-Jasmonoyl-l-Isoleucine Is an Active Jasmonate That Signals through CORONATINE INSENSITIVE 1 and Contributes to the Wound Response in Arabidopsis. Poudel AN, Holtsclaw RE, Kimberlin A, Sen S, Zeng S, Joshi T, Lei Z, Sumner LW, Singh K, Matsuura H, Koo AJ. Plant and Cell Physiology; 60(10):2152-2166.

Date published: October 1, 2019
Featured in this article: Sidharth Sen, Shuai Zeng, Trupti Joshi, Zhentian Lei, Lloyd Sumner, Kamlendra Singh.

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Early genistein exposure of California mice and effects on the gut microbiota-brain axis. Marshall BL, Liu Y, Farrington MJ, Mao J, Helferich WG, Schenk AK, Bivens NJ, Sarma SJ, Lei Z, Sumner LW, Joshi T, Rosenfeld CS. Journal of Endocrinology; 242(2):139-157.

Date published: August 1, 2019
Featured in this article: Jiude Mao, Nathan Bivens, Saurav Sarma, Zhentian Lei, Lloyd Sumner, Trupti Joshi.

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Large-scale profiling of saponins in different ecotypes of Medicago truncatula. Lei Z, Watson BS, Huhman D, Yang DS, Sumner LW. Frontiers in Plant Science; 10:850.

Date published: May 31, 2019
Featured in this article: Zhentian Lei, Lloyd Sumner.

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UHPLC-MS Analyses of Plant Flavonoids. Lei Z, Sumner BW, Bhatia A, Sarma SJ, Sumner LW. Current protocols in plant biology; 4(1):e20085.

Date published: March 1, 2019
Featured in this article: Zhentian Lei, Barbara Sumner, Saurav Sarma, Lloyd Sumner.

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Identification and quantification of phytosterols in black walnut kernels. Vu DC, Lei Z, Sumner LW, Coggeshall MV, Lin C-H. Journal of Food Composition and Analysis; 75:61-69.

Date published: January 1, 2019
Featured in this article: Zhentian Lei, Lloyd Sumner.

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UHPLC-QTOF-MS/MS-SPE-NMR: A Solution to the Metabolomics Grand Challenge of Higher-Throughput, Confident Metabolite Identifications. Bhatia A, Sarma SJ, Lei Z, Sumner LW. Methods in Molecular Biology; 2037:113-133.

Date published: January 1, 2019
Featured in this article: Saurav Sarma, Zhentian Lei, Lloyd Sumner.

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Black Walnut (Juglans nigra) Extracts Inhibit Proinflammatory Cytokine Production from Lipopolysaccharide-Stimulated Human Promonocytic Cell Line U-937. Ho K-V, Schreiber KL, Vu DC, Rottinghaus SM, Jackson DE, Brown CR, Lei Z, Sumner LW, Coggeshall MV, Lin C-H. Frontiers in Pharmacology; 10(SEP):1059.

Date published: January 1, 2019
Featured in this article: Zhentian Lei, Lloyd Sumner.

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2018

MetExpert: An expert system to enhance gas chromatography‒mass spectrometry-based metabolite identifications. Qiu F, Lei Z, Sumner LW. Analytical Chimica Acta; 1037:316-326.

Date published: December 11, 2018
Featured in this article: Zhentian Lei, Lloyd Sumner.

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Metabolomics of two pecan varieties provides insights into scab resistance. Lei Z, Kranawetter C, Sumner BW, Huhman D, Wherritt DJ, Thomas AL, Rohla C, Sumner LW. Metabolites; 8(4):56.

Date published: December 1, 2018
Featured in this article: Zhentian Lei, Clayton Kranawetter, Barbara Sumner, Lloyd Sumner.

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Identifying antibacterial compounds in black walnuts (Juglans nigra) using a metabolomics approach. Ho K-V, Lei Z, Sumner LW, Coggeshall MV, Hsieh H-Y, Stewart GC, Lin C-H. Metabolites; 8(4):58.

Date published: December 1, 2018
Featured in this article: Zhentian Lei, Lloyd Sumner.

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Soy-Induced Fecal Metabolome Changes in Ovariectomized and Intact Female Rats: Relationship with Cardiometabolic Health. Veira-Potter VJ, Cross T-WL, Swanson KS, Sarma SJ, Lei Z, Sumner LW, Rosenfeld CS. Scientific Reports; 8(1):16896.

Date published: December 1, 2018
Featured in this article: Saurav Sarma, Zhentian Lei, Lloyd Sumner.

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Abatement of 2,4-D by H₂O₂ solar photolysis and solar photo-Fenton-like process with minute Fe(III) concentrations. Serra-Clusellas A, De Angelis L, Lin C-H, Vo P, Bayati M, Sumner L, Lei Z, Amaral NB, Bertini LM, Mazza J, Pizzio LR, Stripeikis JD, Rengifo-Herrera JA, Fidalgo de Cortalezzi MM. Water Research; 144:572-580.

Date published: November 1, 2018
Featured in this article: Lloyd Sumner, Zhentian Lei.

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Seminal fluid metabolome and epididymal changes after antibiotic treatment in mice. Rosenfeld CS, Javurek AB, Johnson SA, Lei Z, Sumner LW, Hess RA. Reproduction; 156(1):1-10.

Date published: January 1, 2018
Featured in this article: Zhentian Lei, Lloyd Sumner.

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2016

PlantMAT: A metabolomics tool for predicting the specialized metabolic potential of a system and for large-scale metabolite identifications. Qiu F, Fine DD, Wherritt DJ, Lei Z, Sumner LW. Analytical Chemistry; 88(23):11373-11383.

Date published: December 6, 2016
Featured in this article: Zhentian Lei, Lloyd Sumner.

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2015

MET-XAlign: A Metabolite Cross-Alignment Tool for LC/MS-Based Comparative Metabolomics. Zhang W, Lei Z, Huhman D, Sumner LW, Zhao PX. Analytical Chemistry; 87(18):9114-9119.

Date published: September 15, 2015
Featured in this article: Zhentian Lei, Lloyd Sumner.

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Metabolite profiles of essential oils in citrus peels and their taxonomic implications. Jing L, Lei Z, Zhang G, Pilon AC, Huhman DV, Xie R, Xi W, Zhou Z, Sumner LW. Metabolomics; 11(4):952-963.

Date published: August 22, 2015
Featured in this article: Zhentian Lei, Lloyd Sumner.

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Construction of an Ultrahigh Pressure Liquid Chromatography-Tandem Mass Spectral Library of Plant Natural Products and Comparative Spectral Analyses. Lei Z, Jing L, Qiu F, Zhang H, Huhman D, Zhou Z, Sumner LW. Analytical Chemistry; 87(14):7373-7381.

Date published: July 21, 2015
Featured in this article: Zhentian Lei, Lloyd Sumner.

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Modern plant metabolomics: Advanced natural product gene discoveries, improved technologies, and future prospects. Sumner LW, Lei Z, Nikolau BJ, Saito K. Natural Product Reports; 32(2):212-229.

Date published: February 1, 2015
Featured in this article: Lloyd Sumner, Zhentian Lei.

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2014

Proposed quantitative and alphanumeric metabolite identification metrics. Sumner LW, Lei Z, Nikolau BJ, Saito K, Roessner U, Trengove R. Metabolomics; 10(6):1047-1049.

Date published: October 30, 2014
Featured in this article: Lloyd Sumner, Zhentian Lei.

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MET-COFEA: A liquid chromatography/mass spectrometry data processing platform for metabolite compound feature extraction and annotation. Zhang W, Chang J, Lei Z, Huhman D, Sumner LW, Zhao PX. Analytical Chemistry; 86(13):6245-6253.

Date published: July 1, 2014
Featured in this article: Zhentian Lei, Lloyd Sumner.

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Metabolite identification: are you sure? And how do your peers gauge your confidence?. Creek DJ, Dunn WB, Fiehn O, Griffin JL, Hall RD, Lei Z, Mistrik R, Neumann S, Schymanski EL, Sumner LW, Trengove R, Wolfender J-L. Metabolomics; 10(3):350-353.

Date published: June 1, 2014
Featured in this article: Zhentian Lei, Lloyd Sumner.

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Antifungal activity of citrus essential oils. Jing L, Lei Z, Li L, Xie R, Xi W, Guan Y, Sumner LW, Zhou Z. Journal of Agricultural and Food Chemistry; 62(14):3011-3033.

Date published: April 9, 2014
Featured in this article: Zhentian Lei, Lloyd Sumner.

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2013

Identification of antioxidants in methanol extracts from soymilk. Zhang H, Sumner L, Lei Z-T, Huhman D, Watson B, Fu F-Y, Yu J. Modern Food Science and Technology; 29(8):1999-2003.

Date published: August 1, 2013
Featured in this article: Lloyd Sumner, Zhentian Lei.

Sub-cellular proteomics of Medicago truncatula. Lee J, Lei Z, Watson BS, Sumner LW. Frontiers in Plant Science; 4(APR):112.

Date published: April 30, 2013
Featured in this article: Zhentian Lei, Lloyd Sumner.

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Influence of host chloroplast proteins on Tobacco mosaic virus accumulation and intercellular movement. Bhat S, Folimonova SY, Cole AB, Ballard KD, Lei Z, Watson BS, Sumner LW, Nelson RS. Plant Physiology; 161(1):134-147.

Date published: January 1, 2013
Featured in this article: Zhentian Lei, Lloyd Sumner.

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2012

Root Secreted Metabolites and Proteins Are Involved in the Early Events of Plant-Plant Recognition Prior to Competition. Badri DV, de-la-Peña C, Lei Z, Manter DK, Chaparro JM, Guimarães RL, Sumner LW, Vivanco JM. PLoS ONE; 7(10):e46640.

Date published: October 2, 2012
Featured in this article: Zhentian Lei, Lloyd Sumner.

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MET-IDEA version 2.06; improved efficiency and additional functions for mass spectrometry-based metabolomics data processing. Lei Z, Li H, Chang J, Zhao PX, Sumner LW. Metabolomics; 8:105-110.

Date published: June 1, 2012
Featured in this article: Zhentian Lei, Lloyd Sumner.

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Characterization of an isoflavonoid-specific prenyltransferase from Lupinus albus. Shen G, Huhman D, Lei Z, Snyder J, Sumner LW, Dixon RA. Plant Physiology; 159(1):70-80.

Date published: May 1, 2012
Featured in this article: Zhentian Lei, Lloyd Sumner.

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2011

A lysozyme with antifungal activity from Pithecellobium dulce seeds. Sawasdipuksa N, Lei Z, Sumner LW, Niyomploy P, Sangvanicha P. Food Technology and Biotechnology; 49(4):489-494.

Date published: October 1, 2011
Featured in this article: Zhentian Lei, Lloyd Sumner.

Methyl jasmonate induces ATP biosynthesis deficiency and accumulation of proteins related to secondary metabolism in Catharanthus roseus (L.) G. Hairy Roots. Ruiz-May E, De-La-Peña C, Galaz-Ávalos RM, Lei Z, Watson BS, Sumner LW, Loyola-Vargas VM. Plant and Cell Physiology; 52(8):1401-1421.

Date published: August 1, 2011
Featured in this article: Zhentian Lei, Lloyd Sumner.

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Mass spectrometry strategies in metabolomics. Lei Z, Huhman DV, Sumner LW. Journal of Biological Chemistry; 286(29):25435-25442.

Date published: July 22, 2011
Featured in this article: Zhentian Lei, Lloyd Sumner.

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A legume specific protein database (LegProt) improves the number of identified peptides, confidence scores and overall protein identification success rates for legume proteomics. Lei Z, Dai X, Watson BS, Zhao PX, Sumner LW. Phytochemistry; 72(10):1020-1027.

Date published: July 1, 2011
Featured in this article: Zhentian Lei, Lloyd Sumner.

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2010

Comparative proteomics of yeast-elicited medicago truncatula cell suspensions reveals induction of isoflavonoid biosynthesis and cell wall modifications. Lei Z, Chen F, Watson BS, Nagaraj S, Elmer AM, Dixon RA, Sumner LW. Journal of Proteome Research; 9(12):6220-6231.

Date published: December 3, 2010
Featured in this article: Zhentian Lei, Lloyd Sumner.

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Root secretion of defense-related proteins is development-dependent and correlated with flowering time. De-la-Peña C, Badri DV, Lei Z, Watson BS, Branda MM, Silva-Filho MC, Sumner LW, Vivanco JM. Journal of Biological Chemistry; 285(40):30654-30665.

Date published: October 1, 2010
Featured in this article: Zhentian Lei, Lloyd Sumner.

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Soybean metabolites regulated in root hairs in response to the symbiotic bacterium Bradyrhizobium japonicum. Brechenmacher L, Lei Z, Libault M, Findley S, Sugawara M, Sadowsky MJ, Sumner LW, Stacey G. Plant Physiology; 153(4):1808-1822.

Date published: August 1, 2010
Featured in this article: Zhentian Lei, Lloyd Sumner, Gary Stacey.

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LAP5 and LAP6 encode anther-specific proteins with similarity to chalcone synthase essential for pollen exine development in arabidopsis. Dobritsa AA, Lei Z, Nishikawa S, Urbanczyk-Wochniak E, Huhman DV, Preuss D, Sumner LW. Plant Physiology; 153(3):937-955.

Date published: July 1, 2010
Featured in this article: Zhentian Lei, Lloyd Sumner.

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2009

Proteome analysis of Pithecellobium dulce seeds using two-dimensional gel electrophoresis and tandemmass spectrometry. Sawasdipuksa N, Sumner LW, Lei Z, Sangvanicha P. Journal of the Science of Food and Agriculture; 89(8):1284-1291.

Date published: June 1, 2009
Featured in this article: Lloyd Sumner, Zhentian Lei.

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Transcript and proteomic analysis of developing white lupin (Lupinus albus L.) roots&z. Tian L. Tian L, Lei Z, Aziz N, Dai X, He J, Watson B, Zhao PX, Sumner LW, Dixon RA. BMC Plant Biology; 9:9.

Date published: January 1, 2009
Featured in this article: Zhentian Lei, Lloyd Sumner.

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2008

Root-microbe communication through protein secretion. De-la-Peña C, Lei Z, Watson BS, Sumner LW, Vivanco JM. Journal of Biological Chemistry; 283(37):25247-25255.

Date published: September 12, 2008
Featured in this article: Zhentian Lei, Lloyd Sumner.

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2007

Metabolic profiling and systematic identification of flavonoids and isoflavonoids in roots and cell suspension cultures of Medicago truncatula using HPLC-UV-ESI-MS and GC-MS. Farag MA, Huhman DV, Lei Z, Sumner LW. Phytochemistry; 68(3):342-354.

Date published: February 1, 2007
Featured in this article: Zhentian Lei, Lloyd Sumner.

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Methods, applications and concepts of metabolite profiling: secondary metabolism. Sumner LW, Huhman DV, Urbanczyk-Wochniak E, Lei Z. EXS; 97:195-212.

Date published: January 1, 2007
Featured in this article: Lloyd Sumner, Zhentian Lei.

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Electroelution of intact proteins from SDS-PAGE gels and their subsequent MALDI-TOF MS analysis. Lei Z, Anand A, Mysore KS, Sumner LW. Methods in molecular biology (Clifton, N.J.); 355:353-363.

Date published: January 1, 2007
Featured in this article: Zhentian Lei, Lloyd Sumner.

Proteomics of Medicago truncatula. Lei Z, Nagaraj S, Watson BS, Sumner LW. Plant Proteomics; 121-136.

Date published: January 1, 2007
Featured in this article: Zhentian Lei, Lloyd Sumner.

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2005

A two-dimensional electrophoresis proteomic reference map and systematic identification of 1367 proteins from a cell suspension culture of the model legume Medicago truncatula. Lei Z, Elmer AM, Watson BS, Dixon RA, Mendes PJ, Sumner LW. Molecular and Cellular Proteomics; 4(11):1812-1825.

Date published: November 1, 2005
Featured in this article: Zhentian Lei, Lloyd Sumner.

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2004

Apoplastic extracts from a transgenic wheat line exhibiting lesion-mimic phenotype have multiple pathogenesis-related proteins that are antifungal. Anand A, Lei Z, Sumner LW, Mysore KS, Arakane Y, Bockus WW, Muthukrishnan S. Molecular Plant-Microbe Interactions; 17(12):1306-1317.

Date published: December 1, 2004
Featured in this article: Zhentian Lei, Lloyd Sumner.

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Proteomics of Medicago sativa cell walls. Watson BS, Lei Z, Dixon RA, Sumner LW. Phytochemistry; 65(12):1709-1720.

Date published: June 1, 2004
Featured in this article: Zhentian Lei, Lloyd Sumner.

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